Reading List

Tight hydrophobic core and flexible helices yield MscL with a high tension gating threshold and a membrane area mechanical strain buffer

1. Arjun Sharma
2. Andriy Anishkin
3. Sergei Sukharev
4. Juan M. Vanegas

Atypical Chemokine Receptor 3 “Senses” CXC Chemokine Receptor 4 Activation Through GPCR Kinase Phosphorylation

1. Christopher T. Schafer
2. Qiuyan Chen
3. John J.G. Tesmer
4. Tracy M. Handel

Outer hair cell receptor potentials reveal a local resonance in the mammalian cochlea

1. Andrei N Lukashkin
2. Ian J Russell
3. Oyuna Rybdylova

Structural basis for binding of Drosophila Smaug to the GPCR Smoothened and to the germline inducer Oskar

1. Jana Kubíková
2. Gabrielė Ubartaitė
3. Jutta Metz
4. Mandy Jeske

Phosphorylation motif dictates GPCR C-terminal domain conformation and arrestin interaction

1. Myriam Guillien
2. Assia Mouhand
3. Amin Sagar
4. Aurélie Fournet
5. Frédéric Allemand
6. Glaécia A.N. Pereira
7. Aurélien Thureau
8. Pau Bernadó
9. Jean-Louis Banères
10. Nathalie Sibille

Investigation of adenosine A1 receptor-mediated β-arrestin 2 recruitment using a split-luciferase assay

1. Luisa Saecker
2. Hanns Häberlein
3. Sebastian Franken

Machine Learning-Based Modeling of Olfactory Receptors in Their Inactive State: Human OR51E2 as a Case Study

1. Mercedes Alfonso-Prieto
2. Riccardo Capelli

Small-molecule targeting of GPCR-independent noncanonical G-protein signaling in cancer

1. Jingyi Zhao
2. Vincent DiGiacomo
3. Mariola Ferreras-Gutierrez
4. Shiva Dastjerdi
5. Alain Ibáñez de Opakua
6. Jong-Chan Park
7. Alex Luebbers
8. Qingyan Chen
9. Aaron Beeler
10. Francisco J. Blanco
11. Mikel Garcia-Marcos

Regulated assembly and neurosteroid modulation constrain GABA _A receptor pharmacology in vivo

1. Chang Sun
2. Hongtao Zhu
3. Sarah Clark
4. Eric Gouaux

Structural basis for lysophosphatidylserine recognition by GPR34

1. Tamaki Izume
2. Ryo Kawahara
3. Akiharu Uwamizu
4. Luying Chen
5. Shun Yaginuma
6. Jumpei Omi
7. Hiroki Kawana
8. Fengjue Hou
9. Fumiya K. Sano
10. Tatsuki Tanaka
11. Kazuhiro Kobayashi
12. Hiroyuki H. Okamoto
13. Yoshiaki Kise
14. Tomohiko Ohwada
15. Junken Aoki
16. Wataru Shihoya
17. Osamu Nureki

The ultra-high affinity transport proteins of ubiquitous marine bacteria

1. Ben E. Clifton
2. Uria Alcolombri
3. Gen-Ichiro Uechi
4. Colin J. Jackson
5. Paola Laurino

Deep learning reveals endogenous sterols as allosteric modulators of the GPCR–Gα interface

1. Sanjay Kumar Mohanty
2. Aayushi Mittal
3. Namra Farooqi
4. Aakash Gaur
5. Subhadeep Duari
6. Saveena Solanki
7. Anmol Kumar Sharma
8. Sakshi Arora
9. Suvendu Kumar
10. Vishakha Gautam
11. Nilesh Kumar Dixit
12. Karthika Subramanian
13. Tarini Shankar Ghosh
14. Debarka Sengupta
15. Shashi Kumar Gupta
16. Arul Natarajan Murugan
17. Deepak Sharma
18. Gaurav Ahuja

• Curated by eLife

  eLife Assessment

  The authors present a set of wrappers around previously developed software and machine-learning toolkits, and demonstrate their use in identifying endogenous sterols binding to a GPCR. The resulting pipeline is potentially useful for molecular pharmacology researchers due to its accessibility and ease of use. However, the evidence supporting the GPCR-related findings remains incomplete, as the machine-learning model shows indications of overfitting, and no direct ligand-binding assays are provided for validation.

Reviewed by eLife

Plasticity of the binding pocket in peptide transporters underpins promiscuous substrate recognition

1. Vadim Kotov
2. Maxime Killer
3. Katharina E.J. Jungnickel
4. Jian Lei
5. Giada Finocchio
6. Josi Steinke
7. Kim Bartels
8. Jan Strauss
9. Florine Dupeux
10. Anne-Sophie Humm
11. Irina Cornaciu
12. José A. Márquez
13. Els Pardon
14. Jan Steyaert
15. Christian Löw

The energetics and ion coupling of cholesterol transport through Patched1

1. T. Bertie Ansell
2. Robin A. Corey
3. Lucrezia Vittoria Viti
4. Maia Kinnebrew
5. Rajat Rohatgi
6. Christian Siebold
7. Mark S. P. Sansom

Chemoproteomic Profiling Reveals that Anti-Cancer Natural Product Dankastatin B Covalently Targets Mitochondrial VDAC3

1. Bridget P. Belcher
2. Paulo A. Machicao
3. Binqi Tong
4. Emily Ho
5. Julia Friedli
6. Brian So
7. Helen Bui
8. Yosuke Isobe
9. Thomas J. Maimone
10. Daniel K. Nomura

Structural insights into agonist-binding and activation of the human complement C3a receptor

1. Manish K. Yadav
2. Ravi Yadav
3. Parishmita Sarma
4. Jagannath Maharana
5. Chahat Soni
6. Sayantan Saha
7. Vinay Singh
8. Manisankar Ganguly
9. Shirsha Saha
10. Htet A. Khant
11. Ramanuj Banerjee
12. Arun K. Shukla
13. Cornelius Gati

Differential regulation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) receptor tetramerization by auxiliary subunits

1. Noele Certain
2. Quan Gan
3. Joseph Bennett
4. Helen Hsieh
5. Lonnie P. Wollmuth

Diminishing neuronal acidification by channelrhodopsins with low proton conduction

1. Rebecca Frank Hayward
2. F Phil Brooks
3. Shang Yang
4. Shiqiang Gao
5. Adam E Cohen

• Curated by eLife

  eLife assessment

  This important and compelling study investigates the problem of intracellular acidification induced by commonly-used optogenetic stimulating opsins. The low proton permeability of two high-performance opsins is shown to reduce photostimulated acidification. The findings may be of broad interest in the fields of neuroscience research and optogenetic therapies.

Reviewed by eLife

Determinants of iFGF13-mediated regulation of myocardial voltage-gated sodium (NaV) channels in mouse

1. Adrien Lesage
2. Maxime Lorenzini
3. Sophie Burel
4. Marine Sarlandie
5. Floriane Bibault
6. Cecilia Lindskog
7. Daniel Maloney
8. Jonathan R. Silva
9. R. Reid Townsend
10. Jeanne M. Nerbonne
11. Céline Marionneau

Deep Learning Dynamic Allostery of G-Protein-Coupled Receptors

1. Hung N. Do
2. Jinan Wang
3. Yinglong Miao