Reading List

Characterizing the Ion-Conductive State of the α7-Nicotinic Acetylcholine Receptor via Single-Channel Measurements and Molecular Dynamics Simulations

1. Nauman Sultan
2. Gisela D. Cymes
3. Ada Chen
4. Bernard Brooks
5. Claudio Grosman
6. Ana Damjanovic

Structural basis of insulin receptor antagonism by bivalent site 1-site 2 ligands

1. Amber Vogel
2. Alan Blakely
3. Yuankun Dao
4. Nai-Pin Lin
5. Danny Chou
6. Christopher P. Hill

Engineering antibody–drug conjugates targeting an adhesion GPCR, CD97

1. Takamitsu Hattori
2. Michelle Wang
3. Alexis D. Corrado
4. Suzanne Gross
5. Michelle Fang
6. Injin Bang
7. Nainita Roy
8. Iryna Berezniuk
9. Hayley Donaldson
10. Karenna Groff
11. Niklas Ravn-Boess
12. Akiko Koide
13. Dimitris G. Placantonakis
14. Christopher Y. Park
15. Shohei Koide

Far-red light absorption strategies and their structural basis in Photosystem I of Acaryochloris marina NIES-2412

1. Thomas J. Oliver
2. Eduard Elias
3. Giovanni Consoli
4. Ho Fong Leong
5. Violeta Cordón-Preciado
6. Andrea Fantuzzi
7. Tanai Cardona
8. A. William Rutherford
9. Roberta Croce

Stereoselectivity and functional plasticity of a common ligand-binding pocket in TRPM3

1. Bahar Bazeli
2. Alexander V. Shkumatov
3. Stephan Schenck
4. Jean-Christophe Vanherck
5. Annelies Janssens
6. Stéphane A. H. Spieser
7. Damien Marchand
8. Robbe Roelens
9. Patrick Chaltin
10. Arnaud Marchand
11. Joris Vriens
12. Thomas Voets
13. Janine D. Brunner

Evolution of Temperature Dependence of TRPM2 Channel Gating and Inactivation in Vertebrates

1. Adam Bartok
2. Adam V. Toth
3. László Csanády

The energy barrier model in membrane biophysics: Ion flow, current–voltage relations, and Donnan osmosis

1. Gerald Manning

Small molecule inhibitors of the NorA multidrug efflux pump potentiate antibiotic activity by binding the outward-open conformation

1. Janine L. Gray
2. Elizabeth V. K. Ledger
3. Tiffany Suwatthee
4. Thomas J. Burden
5. Konstantina Arvaniti
6. Amber Sefton
7. Lydia E. Papagora
8. Thomas B. Clarke
9. Jennifer Riley
10. Erika G. Pinto
11. Fraser Cunningham
12. Ian H. Gilbert
13. David Gray
14. Da-Neng Wang
15. Kevin D. Read
16. Thomas Lanyon-Hogg
17. Nathaniel J. Traaseth
18. Andrew M. Edwards
19. Edward W. Tate

Trikafta restores thermodynamic coupling between two nucleotide binding domains for potentiating CFTR activity

1. Guangyu Wang

Go/z-biased coupling profile of the dopamine D3 receptor

1. Lucrezia Zanetti
2. Luca Franchini
3. Shirsha Saha
4. Yini Liao
5. Brian S. Muntean
6. Cesare Orlandi

SLC26A11 is an atypical solute carrier with dual transport-channel function mediating lysosomal sulfate transport

1. Benedikt T Kuhn
2. Peter Kovermann
3. Bassam G Haddad
4. Tim Rasmussen
5. Tamsanga Hove
6. Stefanie Bungert-Pluemke
7. Bettina Boettcher
8. Jan-Philipp Machtens
9. Christoph Fahlke
10. Eric R. Geertsma

Single-molecule localization microscopy reveals the molecular organization of endogenous membrane receptors

1. Patrick Eiring
2. Maximilian J. Steinhardt
3. Nele Bauer
4. Cornelia Vogt
5. Umair Munawar
6. Seungbin Han
7. Thomas Nerreter
8. Hermann Einsele
9. K. Martin Kortüm
10. Sören Doose
11. Markus Sauer

Molecular characterization of an adhesion GPCR signal transduction

1. M. Marfoglia
2. L. Dumas
3. B.S. Yang
4. A. Oggier
5. M. Pedraza
6. M. Hijazi
7. A.N. Larabi
8. K. Lau
9. F. Pojer
10. M.A. Nash
11. P. Barth

Beyond Gatekeeping: Efflux Pumps Remotely Destabilize Cytoplasmic Drug–Target Interactions by Limiting Rebinding

1. Subrata Dev
2. Keiran Stevenson
3. Dai Le
4. Minsu Kim

Surface-Attached Model Lipid Membranes Derived from Human Red Blood Cells

1. Sanyukta Prakash Mudakannavar
2. Matthew D. Mitchell
3. Katherine Bai
4. Robert J. Rawle

Atomistic Mechanism of Calcium-Mediated Inward Rectification of the MthK Potassium Channel by Solid-State NMR and MD Simulations

1. Carl Öster
2. Reinier de Vries
3. Juan Li
4. Denis Qoraj
5. Sascha Lange
6. Chaowei Shi
7. Wojciech Kopec
8. Bert L de Groot
9. Adam Lange

Active regulation of the epidermal growth factor receptor by the membrane bilayer

1. Shwetha Srinivasan
2. Xingcheng Lin
3. Xuyan Chen
4. Raju Regmi
5. Bin Zhang
6. Gabriela S Schlau-Cohen

• Curated by eLife

  eLife Assessment

  The authors describe an interesting approach to studying the dynamics and function of membrane proteins in different lipid environments. The fundamental findings have theoretical and practical implications beyond the study of EGFR to all membrane signalling proteins. The evidence supporting the conclusions is compelling, based on the use of a nanodisk system to study membrane proteins in vitro, combined with state-of-the-art single-molecule FRET. The work will be of broad interest to cell biologists and biochemists.

Reviewed by eLife

Molecular insights into ligand recognition and signaling of GPR99/OXGR1

1. Aijun Liu
2. Yezhou Liu
3. Yuanzhengyang Long
4. Richard D. Ye

Deep learning-based joint sequence–structure de novo membrane protein design

1. Lucas S.P. Rudden
2. Remo Bättig
3. Vinnie Andrews
4. Julie V. Nguyen
5. Martin Stoll
6. Lorenzo Scutteri
7. Michal Winnicki
8. Melissa J. Call
9. Matthew E. Call
10. Damien Thévenin
11. Patrick Barth

Mechanism of Tethered Agonist Binding to an Adhesion G-Protein-Coupled Receptor

1. Keya Joshi
2. Yinglong Miao