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A list by Biophysics Colab

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  7. Zinc is a Key Regulator of the Sperm-Specific K+ Channel (Slo3) Function

    1. Rizki Tsari Andriani
    2. Tanadet Pipatpolkai
    3. Haruhiko Miyata
    4. Masahito Ikawa
    5. Yasushi Okamura
    6. Takafumi Kawai

    • Curated by eLife

      eLife Assessment

      This study presents a useful contribution to understanding zinc regulation of sperm physiology, specifically its inhibitory effects on the sperm-specific potassium channel Slo3. However, the evidence supporting the claims is incomplete, as critical experimental controls are lacking, key mechanistic aspects remain insufficiently explored, and experimental descriptions are often inadequate, making it difficult to fully assess the findings. Strengthening the study with additional electrophysiological recordings in sperm cells, improved imaging controls, and clearer methodological descriptions would enhance its impact and rigor.

    Reviewed by eLife

    4 evaluationsAppears in 2 listsLatest version Latest activity

  10. Structure and Cl- Conductance Properties of the Open State of Human CFTR

    1. Zhi-Wei Zeng
    2. Christopher E Ing
    3. Régis Pomès

    • Curated by eLife

      eLife Assessment

      This important study reports a detailed computational analysis of the CFTR ion channel's permeation mechanism, advancing our understanding of its structure-function relationship. The conclusions are based on extensive molecular dynamics simulations and thorough analysis, but the use of an approximate chloride ion model, known to underestimate key ion-protein interactions, leaves them incomplete without experimental or alternative computational validation. The work will be of interest to biophysicists working on CFTR and cystic fibrosis.

    Reviewed by eLife

    5 evaluationsAppears in 2 listsLatest version Latest activity

  12. Structural mechanisms of PIP 2 activation and SEA0400 inhibition in human cardiac sodium-calcium exchanger NCX1

    1. Jing Xue
    2. Weizhong Zeng
    3. Scott John
    4. Nicole Attiq
    5. Michela Ottolia
    6. Youxing Jiang

    • Curated by eLife

      eLife Assessment

      NCX1 is an important cardiac Ca2+/Na+ exchanger whose activity is tightly regulated. This manuscript describes the structural basis of activation by the lipid PIP2 and inhibition by binding of a small molecule to NCX1. These results provide key insights into NCX1 regulation and cellular Ca2+ signaling, but the evidence presented is still incomplete.

    Reviewed by eLife

    4 evaluationsAppears in 2 listsLatest version Latest activity

  20. AER-270 and TGN-020 are not aquaporin-4 water channel blockers

    1. Lucas Unger
    2. Kim Wagner
    3. Jonas H Steffen
    4. Malene Lykke Wind
    5. Tamim Al-Jubair
    6. Hongjun Zou
    7. Charlotte Clarke-Bland
    8. Rebecca Murray
    9. Bareerah Qureshi
    10. Susanna Lundström
    11. Massimiliano Gaetani
    12. David Poyner
    13. Hoor Ayub
    14. Mark Wheatley
    15. Pontus Gourdon
    16. Andrea J Yool
    17. Susanna Törnroth-Horsefield
    18. Roslyn M Bill
    19. Mootaz M. Salman
    20. Philip Kitchen
    Appears in 1 listLatest version
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