Reading List

Small molecule-mediated targeted protein degradation of voltage-gated sodium channels involved in pain

1. Alexander Chamessian
2. Maria Payne
3. Isabelle Gordon
4. Mingzhou Zhou
5. Robert Gereau

Convergent Agonist and Heat Activation of Nociceptor TRPM3

1. Sushant Kumar
2. Fei Jin
3. Sung Jin Park
4. Wooyoung Choi
5. Sarah I. Keuning
6. Richard P. Massimino
7. Simon Vu
8. Wei Lü
9. Juan Du

Unveiling G-Protein-Coupled Receptor Conformational Dynamics via Metadynamics Simulations and Markov State Models

1. Rita A. Roessner
2. Nicolas Floquet
3. Maxime Louet

Disease-associated Kv1.3 Variants are Energy Compromised with Impaired Nascent Chain Folding

1. Aaron Sykes
2. Lannawill Caruth
3. Sophia Gross
4. Shefali Setia Verma
5. Toshinori Hoshi
6. Carol Deutsch

Two stages of substrate discrimination dictate selectivity in the E. coli MetNI-Q ABC transporter system

1. Janet G. Yang
2. Hulda Yuchun Chen
3. John H. Guardado
4. Maile Gardner
5. Matthew S. Foronda

Role of N -glycosylation as a determinant of ATG9A conformations and activity

1. Matteo Lambrughi
2. Mattia Utichi
3. Henri-Baptiste Marjault
4. Christian B. Borg
5. Sergio Esteban Echeverría
6. Kenji Maeda
7. Nicholas M.I. Taylor
8. Elisa Fadda
9. Marja Jäättelä
10. Elena Papaleo

Mechanistic Elucidation of CLIC1 Membrane Insertion via Structural and Dynamic Modulation

1. Joseph Cassar
2. Angela Serrano-Sanchez
3. Jack Bragg
4. Encarnacion Medina-Carmona
5. Felipe Ossa
6. Gary Thompson
7. Vahitha Abdul-Salam
8. Lorena Varela Alvarez
9. Jose L. Ortega-Roldan

Bidirectional communication between nucleotide and substrate binding sites in a type IV multidrug ABC transporter

1. Victor Hugo Pérez Carrillo
2. Margot Di Cesare
3. Dania Rose-Sperling
4. Waqas Javed
5. Hannes Neuweiler
6. Julien Marcoux
7. Cédric Orelle
8. Jean-Michel Jault
9. Ute A. Hellmich

Inhibition of constitutive activity of the atypical chemokine receptor ACKR3 by the small-molecule inverse agonist VUF16840

1. Reggie Bosma
2. Desislava Nesheva
3. Merel Rijnsburger
4. Rick Riemens
5. Justyna M. Adamska
6. Max Meyrath
7. Simon Mobach
8. C. Maurice Buzink
9. Iwan J. P. de Esch
10. Martyna Szpakowska
11. Maikel Wijtmans
12. Andy Chevigne
13. Henry F. Vischer
14. Rob Leurs

Molecular basis of ligand binding and receptor activation at the human A3 adenosine receptor

1. Liudi Zhang
2. Jesse I. Mobbs
3. Felix M. Bennetts
4. Hariprasad Venugopal
5. Anh T.N. Nguyen
6. Arthur Christopoulos
7. Daan van der Es
8. Laura H. Heitman
9. Lauren T. May
10. Alisa Glukhova
11. David M. Thal

WITHDRAWN: Intrinsic Opening of BK Channels Derives from Inherent Leakage in Hydrophobic Gating

1. Zhiguang Jia
2. Guohui Zhang
3. Jingyi Shi
4. Jianmin Cui
5. Jianhan Chen

A photoswitchable positive allosteric modulator to control the activation of the metabotropic glutamate receptor 5 by light

1. Anaëlle Dumazer
2. Roser Borras-Tuduri
3. Iona Truong
4. Xiaojing Cong
5. Fanny Malhaire
6. Xavier Rovira
7. Xavier Gomez-Santacana
8. Laurent Givalois
9. Guillaume Lebon
10. Amadeu Llebaria
11. Cyril Goudet

Bottom-up design of calcium channels from defined selectivity filter geometry

1. Yulai Liu
2. Connor Weidle
3. Ljubica Mihaljević
4. Joseph L. Watson
5. Zhe Li
6. Le Tracy Yu
7. Sagardip Majumder
8. Andrew J. Borst
9. Kenneth D. Carr
10. Ryan D. Kibler
11. Tamer M. Gamal El-Din
12. William A. Catterall
13. David Baker

Electric field-induced pore constriction in the human Kv2.1 channel

1. Venkata Shiva Mandala
2. Roderick MacKinnon

Atomistic Mechanism of Non-Canonical Voltage Gating in TREK K _2P Channels

1. Yessenbek K. Aldakul
2. Marcus Schewe
3. Carlos C. Diez
4. Songhwan Hwang
5. Thomas Baukrowitz
6. Han Sun

Database Permeating through Time, Space, and Medicine: A sequence, structure, and clinical compilation and comparison of transmembrane amino acids in VGL ion channels

1. Frank Yeh
2. Arya Patel
3. Matthew Mun
4. Youjin Oh
5. Richard W. Aldrich

Docking 14 million virtual isoquinuclidines against the mu and kappa opioid receptors reveals dual antagonists-inverse agonists with reduced withdrawal effects

1. Seth F. Vigneron
2. Shohei Ohno
3. Joao Braz
4. Joseph Y. Kim
5. Oh Sang Kweon
6. Chase Webb
7. Christian Billesbølle
8. Karnika Bhardwaj
9. John Irwin
10. Aashish Manglik
11. Allan I. Basbaum
12. Jonathan A. Ellman
13. Brian K. Shoichet

Structural and Mechanistic Insights into Symmetry Conversion in Plant GORK K ⁺ Channel Regulation

1. Qi-yu Li
2. Li Qin
3. Ling-hui Tang
4. Chun-rui Zhang
5. Shouguang Huang
6. Ke Wang
7. Gao-hua Zhang
8. Ning-jie Hao
9. Qian Xiao
10. Tongxin Niu
11. Min Su
12. Rainer Hedrich
13. Yu-hang Chen

Atomistic Simulation of Voltage Activation of a Truncated BK Channel

1. Zhiguang Jia
2. Jianhan Chen

• Curated by eLife

  eLife Assessment

  This valuable study addresses the structural basis of voltage-activation of BK channels using atomistic simulations of several microseconds, to assess conformational changes that underlie both voltage-sensing and gating of the pore. The findings, including movement of specific charged residues, combined with the degree to which these movements are coupled to pore movements, provide a solid basis for understanding voltage-gating mechanisms in this class of channels. This paper will likely be of interest to ion channel biologists and biophysicists focused on voltage-dependent channel gating mechanisms.

Reviewed by eLife

The bile acid-sensitive ion channel is gated by Ca ²⁺ -dependent conformational changes in the transmembrane domain

1. Makayla M. Freitas
2. Eric Gouaux