Reading list

Structure of the human K _2P 13.1(THIK-1) channel reveals a novel hydrophilic pore restriction and lipid cofactor site

1. Shatabdi Roy-Chowdhury
2. Seil Jang
3. Fayal Abderemane-Ali
4. Fiona Naughton
5. Michael Grabe
6. Daniel L. Minor

Molecular mapping and functional validation of GLP-1R cholesterol binding sites in pancreatic beta cells

1. Affiong I Oqua
2. Kin Chao
3. Liliane El Eid
4. Lisa Casteller
5. Alba Miguéns
6. Sebastian Barg
7. Ben Jones
8. Jorge Bernadino de la Serna
9. Sarah L Rouse
10. Alejandra Tomas

• Curated by eLife

  eLife assessment

  This study presents a valuable finding on the role of cholesterol-binding site on GLP-1 receptors and functionally characterizes the impact of this mutation on receptor behavior in the membrane and downstream signaling. The computational and experimental approaches used in the study to arrive at the conclusions are solid. The clinical ramifications are unclear at this point, but the study is a helpful addition to the scientific community working on receptor biology and drug development.

Reviewed by eLife

Piezo1 is a mechanosensor of soft matrix viscoelasticity

1. Mariana A. G. Oliva
2. Giuseppe Ciccone
3. Jiajun Luo
4. Jonah L. Voigt
5. Patrizia Romani
6. Oana Dobre
7. Sirio Dupont
8. Massimo Vassalli
9. Manuel Salmeron-Sanchez

Lipid composition of the membrane governs the oligomeric organization of VDAC1

1. Elodie Lafargue
2. Jean-Pierre Duneau
3. Nicolas Buzhinsky
4. Pamela Ornelas
5. Alexandre Ortega
6. Varun Ravishankar
7. James Sturgis
8. Ignacio Casuso
9. Lucie Bergdoll

KCNG4 genetic variant linked to migraine prevents expression of KCNB1

1. Gabriel Lacroix
2. Shreyas Bhat
3. Zerghona Shafia
4. Rikard Blunck

Structural basis for the transport and regulation mechanism of the Multidrug resistance-associated protein 2

1. Eriko Koide
2. Harlan L. Pietz
3. Jean Beltran
4. Jue Chen

The ABC transporter MsbA in a dozen environments

1. Arne Moeller
2. Lea Hoffmann
3. Anika Baier
4. Lara Jorde
5. Michael Kamel
6. Jan-Hannes Schäfer
7. Kilian Schnelle
8. Alischa Scholz
9. Dmitry Shvarev
10. Jaslyn Wong
11. Kristian Parey
12. Dovile Januliene

Molecular principles of redox-coupled sodium pumping of the ancient Rnf machinery

1. Anuj Kumar
2. Jennifer Roth
3. Hyunho Kim
4. Patricia Saura
5. Stefan Bohn
6. Tristan Reif-Trauttmansdorff
7. Anja Schubert
8. Ville R. I. Kaila
9. Jan M. Schuller
10. Volker Müller

Interplay between phosphorylation and oligomerization tunes the conformational ensemble of SWEET transporters

1. Austin T. Weigle
2. Diwakar Shukla

The C-terminal activating domain promotes Panx1 channel opening

1. Erik Henze
2. Jacqueline J. Ehrlich
3. Janice L. Robertson
4. Toshimitsu Kawate

Mg ²⁺ -dependent mechanism of environmental versatility in a multidrug efflux pump

1. Benjamin Russell Lewis
2. Muhammad R. Uddin
3. Katie M. Kuo
4. Laila M. N. Shah
5. Nicola J. Harris
6. Paula J. Booth
7. Dietmar Hammerschmid
8. James C. Gumbart
9. Helen I. Zgurskaya
10. Eamonn Reading

Ethosuximide: subunit- and Gβγ-dependent blocker and reporter of allosteric changes in GIRK channels

1. Boris Shalomov
2. Theres Friesacher
3. Daniel Yakubovich
4. J. Carlo Combista
5. Haritha P. Reddy
6. Shoham Dabbah
7. Harald Bernsteiner
8. Eva-Maria Zangerl-Plessl
9. Anna Stary-Weinzinger
10. Nathan Dascal

A Second Drug Binding Site in P2X3

1. Trung Thach
2. KanagaVijayan Dhanabalan
3. Prajwal Prabhakarrao Nandekar
4. Seth Stauffer
5. Iring Heisler
6. Sarah Alvarado
7. Jonathan Snyder
8. Ramaswamy Subramanian

Specificity and tunability of efflux pumps: a new role for the proton gradient?

1. Matthew Gerry
2. Duncan Kirby
3. Boian S. Alexandrov
4. Dvira Segal
5. Anton Zilman

Structure of the Ion Channel Kir7.1 and Implications for its Function in Normal and Pathophysiologic States

1. Alys Peisley
2. Ciria C. Hernandez
3. Naima S. Dahir
4. Laura Koepping
5. Ashleigh Raczkowski
6. Min Su
7. Masoud Ghamari-Langroudi
8. Xinrui Ji
9. Luis E. Gimenez
10. Roger D. Cone

Four-color single-molecule imaging system for tracking GPCR dynamics with fluorescent HiBiT peptide

1. Toshiki Yoda
2. Yasushi Sako
3. Asuka Inoue
4. Masataka Yanagawa

Noncanonical roles of chemokine regions in CCR9 activation revealed by structural modeling and mutational mapping

1. Ines De Magalhaes Pinheiro
2. John R.D. Dawson
3. Nicolas Calo
4. Marianne Paolini-Bertrand
5. Kalyana Bharati Akondi
6. Gavin Tan
7. Tracy M. Handel
8. Irina Kufareva
9. Oliver Hartley

Small molecule NS11021 promotes BK channel activation by increasing inner pore hydration

1. Erik B. Nordquist
2. Zhiguang Jia
3. Jianhan Chen

Improving Olfactory Receptor Structure Modeling via Hybrid Methods

1. Bhavika Berwal
2. Pinaki Saha
3. Ritesh Kumar

Diverse toxins exhibit a common binding mode to the Nicotinic Acetylcholine Receptors

1. Hung N. Do
2. Jessica Z. Kubicek-Sutherland
3. S. Gnanakaran