Reading List

Angiotensin receptor conformations stabilized by biased ligands differentially modulate β-arrestin interactions

1. Matthias Elgeti
2. Julia Belyaeva
3. Mahdi Bagherpoor Helabad
4. Dean P. Staus
5. Laura M. Wingler

Mechanism of SK2 channel gating and its modulation by the bee toxin apamin and small molecules

1. Samantha J Cassell
2. Weiyan Li
3. Simon Krautwald
4. Maryam Khoshouei
5. Yan Tony Lee
6. Joyce Hou
7. Wendy Guan
8. Stefan Peukert
9. Wilhelm A Weihofen
10. Jonathan R Whicher

• Curated by eLife

  eLife Assessment

  In this important manuscript, Cassell and colleagues set out on a mechanistic and pharmacological exploration of an engineered chimeric small conductance calcium-activated potassium channel 2 (SK2). They show convincing evidence that the SK2 channel possesses a unique extracellular structure that modulates the conductivity of the selectivity filter, and that this structure is the target for the SK2 inhibitor apamin. While the interpretations are sound and the writing is clear, the manuscript would be strengthened by providing more detailed information for the electrophysiological experiments and the structural analyses attempted, in addition to relating dilation of the filter to mechanisms of inactivation in other potassium channels. This high-quality study will be of interest to membrane protein structural biologists, ion channel biophysicists, and chemical biologists, and will inform future drug development targeting SK channels.

Reviewed by eLife

Molecular fingerprints of a convergent mechanism orchestrating diverse ligand recognition and species-specific pharmacology at the complement anaphylatoxin receptors

1. Sudha Mishra
2. Manish K. Yadav
3. Annu Dalal
4. Manisankar Ganguly
5. Ravi Yadav
6. Kazuhiro Sawada
7. Divyanshu Tiwari
8. Nabarun Roy
9. Nilanjana Banerjee
10. Jenny N. Fung
11. Jianina Marallag
12. Cedric S. Cui
13. Xaria X. Li
14. John D. Lee
15. Calvin Aaron Dsouza
16. Shirsha Saha
17. Parishmita Sarma
18. Ganita Rawat
19. Houming Zhu
20. Htet A. Khant
21. Richard J. Clark
22. Fumiya K. Sano
23. Ramanuj Banerjee
24. Trent M. Woodruff
25. Osamu Nureki
26. Cornelius Gati
27. Arun K. Shukla

Antibiotics-induced conformational heterogeneity of a multidrug transporter revealed by single-molecule FRET

1. Hassan Maklad
2. Tom Kache
3. Aurélie Roth
4. Maria Mamkaeva
5. Cédric Govaerts
6. Jelle Hendrix
7. Chloé Martens

Lipid gating of BK channels and mechanism of activation by negatively charged lipids

1. Andrei Mironenko
2. Bert L. de Groot
3. Wojciech Kopec

Structure-function analysis of lithium-ion selectivity of voltage-gated sodium channel

1. Yuki K. Maeda
2. Kentaro Kojima
3. Tomoe Y. Nakamura
4. Toru Nakatsu
5. Katsumasa Irie

Molecular Basis of Sodium Channel Inactivation

1. Francisco Bezanilla
2. Yichen Liu
3. Jason Galpin
4. Christopher Ahern

Molecular mechanism of substrate transport by human peroxisomal ABCD3

1. Meghna Gupta
2. Nitesh Kumar Khandelwal
3. Devin J. Seka
4. Sree Ganesh Balasubramani
5. Miles Sasha Dickinson
6. Alexander Myasnikov
7. Ignacia Echeverria
8. Robert M. Stroud

Allosteric Control of Super-Agonism in a Ligand-Gated Ion Channel

1. Franco Viscarra
2. Teresa Minguez
3. Isabel Bermudez-Diaz
4. Philip C Biggin

Multiple weak brakes act in concert to regulate STIM1 and control store-operated calcium entry

1. Ruoyi Qiu
2. Richard S. Lewis

TRPM8 Protein Dynamics Correlates with Ligand Structure and Cellular Function

1. Mubark D. Mebrat
2. Dustin D. Luu
3. Jacob K. Hilton
4. Minjoo Kim
5. Kaitlyn Parrott
6. Brian R. Cherry
7. Marcia Levitus
8. V. Blair Journigan
9. Wade D. Van Horn

Development of visible light-sensitive human OPN5 via single amino acid substitution

1. Yusuke Sakai
2. Richard J. McDowell
3. Robert J. Lucas

Structure-based identification of GIRK2-PIP2 modulators among known drugs and metabolites using docking, MM-GBSA, ADMET, and molecular dynamics

1. Danko Jeremic
2. Lydia Jiménez-Díaz
3. Juan D. Navarro-López

The Role of Chloride Ions in Serotonin Transport

1. Jiahui Huang
2. Annika Backer
3. Stacy Uchendu
4. Bethlehem Bekele
5. Qingyang Chen
6. Esam Orabi
7. Robyn Stix
8. Yuan-Wei Zhang
9. Gary Rudnick
10. Eva Hellsberg
11. Lucy R. Forrest

Carboxyl Terminal Domain Missense Mutations Alter Distinct Gating Properties of the Cardiac Sodium Channel

1. Akshay Sharma
2. Christopher Marra
3. Nomon Mohammad
4. Vasilisa Iatckova
5. Lillian Lawrence
6. Mitchell Goldfarb

Identification and Rescue of Congenital Hyperinsulinism-Associated ABCC8 Mutations that Impair K _ATP Channel Trafficking

1. Assmaa ElSheikh
2. Yi-Ying Kuo
3. Kara E. Boodhansingh
4. Zhongying Yang
5. Charles A. Stanley
6. Diva D. De Leon
7. Show-Ling Shyng

Closed State Structure of the Pore Revealed by Uncoupled Shaker K+ Channel

1. Francisco Bezanilla
2. Yichen Liu
3. Carlos Bassetto
4. Gustavo Contreras
5. Eduardo Perozo

Conformational biosensors delineate endosomal G protein regulation by GPCRs

1. Brian Wysolmerski
2. Emily E. Blythe
3. Mark von Zastrow

Targeting the selectivity filter to drastically alter the activity and substrate spectrum of a promiscuous metal transporter

1. Yuhan Jiang
2. Michael Nikolovski
3. Tianqi Wang
4. Keith MacRenaris
5. Thomas V. O’Halloran
6. Jian Hu

Structural insights into allosteric mechanism of glycine transporter-mediated analgesia

1. Ryan P. Cantwell Chater
2. Julian Peiser-Oliver
3. Tanmay K. Pati
4. Ada S. Quinn
5. Irina Lotsaris
6. Zachary J. Frangos
7. Anna E. Tischer
8. Billy J Williams-Noonan
9. Megan L. O’Mara
10. Michael Michaelides
11. Sarasa A. Mohammadi
12. Christopher L. Cioffi
13. Robert J. Vandenberg
14. Azadeh Shahsavar