Reading List

Folding correctors can restore CFTR posttranslational folding landscape by allosteric domain–domain coupling

1. Naoto Soya
2. Haijin Xu
3. Ariel Roldan
4. Zhengrong Yang
5. Haoxin Ye
6. Fan Jiang
7. Aiswarya Premchandar
8. Guido Veit
9. Susan P. C. Cole
10. John Kappes
11. Tamás Hegedüs
12. Gergely L. Lukacs

Membrane Mimetic-Dependence of GPCR Energy Landscapes

1. Naveen Thakur
2. Arka Prabha Ray
3. Edward Lyman
4. Zhan-Guo Gao
5. Kenneth A. Jacobson
6. Matthew T. Eddy

Development of covalent chemogenetic K2P channel activators

1. Parker E. Deal
2. Haerim Lee
3. Abhisek Mondal
4. Marco Lolicato
5. Philipe Ribeiro Furtado de Mendonça
6. Holly Black
7. Seil Jang
8. Xochina El-Hilali
9. Clifford Bryant
10. Ehud Y. Isacoff
11. Adam R. Renslo
12. Daniel L. Minor

Interaction of GAT1 with sodium ions: from efficient recruitment to stabilisation of substrate and conformation

1. Erika Lazzarin
2. Ralph Gradisch
3. Sophie MC Skopec
4. Leticia Alves da Silva
5. Chiara Sebastianelli-Schoditsch
6. Dániel Szöllősi
7. Julian Maier
8. Sonja Sucic
9. Marko Roblek
10. Baruch I Kanner
11. Harald H Sitte
12. Thomas Stockner

• Curated by eLife

  eLife Assessment

  The study elucidates a detailed molecular mechanism of the initial stages of transport in the medically relevant Na+-coupled GABA neurotransmitter transporter GAT1 and thus generates important new insights into this protein family. In particular, it presents convincing evidence for the presence of a "staging binding site" that locally concentrates Na+ ions to increase transport activity, whilst solid evidence for how Na+ binding influences larger scale dynamics.

Reviewed by eLife

Highly biased agonism for GPCR ligands via nanobody tethering

1. Shivani Sachdev
2. Brendan A. Creemer
3. Thomas J. Gardella
4. Ross W. Cheloha

Fitness landscape of substrate-adaptive mutations in evolved amino acid-polyamine-organocation transporters

1. Foteini Karapanagioti
2. Úlfur Águst Atlason
3. Dirk J Slotboom
4. Bert Poolman
5. Sebastian Obermaier

• Curated by eLife

  eLife assessment

  This important manuscript describes experimental evolution experiments using a novel genetic system in yeast, showing that solute carrier transporters can incorporate additional functionality through the introduction of point mutations to either the ligand binding site or gating helices. These findings provide convincing evidence to establish that for Amino Acid transporters of the APC-type family, evolution to recognize new substrates passes through generalist intermediates that can transport most amino acids.

Reviewed by eLife

Structural identification of a selectivity filter in CFTR

1. Jesper Levring
2. Jue Chen

Structural basis for CFTR inhibition by CFTR _inh -172

1. Paul Young
2. Jesper Levring
3. Karol Fiedorczuk
4. Scott C. Blanchard
5. Jue Chen

Bayesian network models identify cooperative GPCR:G protein interactions that contribute to G protein coupling

1. Elizaveta Mukhaleva
2. Ning Ma
3. Wijnand J.C. van der Velden
4. Grigoriy Gogoshin
5. Sergio Branciamore
6. Supriyo Bhattacharya
7. Andrei S. Rodin
8. Nagarajan Vaidehi

A subgroup of light-driven sodium pumps with an additional Schiff base counterion

1. E. Podoliak
2. G. H. U. Lamm
3. E. Marin
4. A. V. Schellbach
5. D. A. Fedotov
6. A. Stetsenko
7. M. Asido
8. N. Maliar
9. G. Bourenkov
10. T. Balandin
11. C. Baeken
12. R. Astashkin
13. T. R. Schneider
14. A. Bateman
15. J. Wachtveitl
16. I. Schapiro
17. V. Busskamp
18. A. Guskov
19. V. Gordeliy
20. A. Alekseev
21. K. Kovalev

TMEM65-dependent Ca ²⁺ extrusion safeguards mitochondrial homeostasis

1. Massimo Vetralla
2. Lena Wischhof
3. Vanessa Cadenelli
4. Enzo Scifo
5. Dan Ehninger
6. Rosario Rizzuto
7. Daniele Bano
8. Diego De Stefani

Optimizing Cryo-EM Structural Analysis of G _i -coupling Receptors via Engineered G _t and Nb35 Application

1. Hidetaka S. Oshima
2. Fumiya K. Sano
3. Hiroaki Akasaka
4. Aika Iwama
5. Wataru Shihoya
6. Osamu Nureki

Atomistic mechanism of coupling between cytosolic sensor domain and selectivity filter in TREK K2P channels

1. Berke Türkaydin
2. Marcus Schewe
3. Elena Barbara Riel
4. Friederike Schulz
5. Johann Biedermann
6. Thomas Baukrowitz
7. Han Sun

Semi‐synthetic nanobody‐ligand conjugates exhibit tunable signaling properties and enhanced transcriptional outputs at neurokinin receptor‐1

1. Nayara Braga Emidio
2. Ross W. Cheloha

Reviewed by Biophysics Colab

An Ultrasensitive Genetically Encoded Voltage Indicator Uncovers the Electrical Activity of Non‐Excitable Cells

1. Philipp Rühl
2. Anagha G. Nair
3. Namrata Gawande
4. Sassrika N. C. W. Dehiwalage
5. Lukas Münster
6. Roland Schönherr
7. Stefan H. Heinemann

Reviewed by Arcadia Science

Architecture and rearrangements of a sperm-specific Na ⁺ /H ⁺ exchanger

1. Kamalendu Pal
2. Sandipan Chowdhury

Structural and molecular basis of choline uptake into the brain by FLVCR2

1. Rosemary J. Cater
2. Dibyanti Mukherjee
3. Eva Gil-Iturbe
4. Satchal K. Erramilli
5. Ting Chen
6. Katie Koo
7. Nicolás Santander
8. Andrew Reckers
9. Brian Kloss
10. Tomasz Gawda
11. Brendon C. Choy
12. Zhening Zhang
13. Aditya Katewa
14. Amara Larpthaveesarp
15. Eric J. Huang
16. Scott W. J. Mooney
17. Oliver B. Clarke
18. Sook Wah Yee
19. Kathleen M. Giacomini
20. Anthony A. Kossiakoff
21. Matthias Quick
22. Thomas Arnold
23. Filippo Mancia

Human proton channels accumulate in cholesterol dependent membrane domains via direct interaction with stomatin

1. Artem G. Ayuyan
2. Vladimir V. Cherny
3. Gustavo Chaves
4. Boris Musset
5. Fredric S. Cohen
6. Thomas E. DeCoursey

Structural basis of lipid head group entry to the Kennedy pathway by FLVCR1

1. Yeeun Son
2. Timothy C. Kenny
3. Artem Khan
4. Kıvanç Birsoy
5. Richard K. Hite

Central pore-opening structure and gating of the mechanosensitive PIEZO1 channel

1. Sijia Liu
2. Xuzhong Yang
3. Xudong Chen
4. Xiaochun Zhang
5. Jinghui Jiang
6. Li Wang
7. Jingyi Yuan
8. Wenhao Liu
9. Heng Zhou
10. Kun Wu
11. Boxue Tian
12. Xueming Li
13. Bailong Xiao