Reading List

GPRC5A regulates keratinocyte adhesion and migration through nuclear translocation of its C-terminus region

1. Sarah Chanteloube
2. Choua Ya
3. Gabrielle Le Provost
4. Aurore Berthier
5. Cindy Dieryckx
6. Sandrine Vadon-Le Goff
7. Florence Nadal
8. Bérengère Fromy
9. Romain Debret

Constant-pH Molecular Dynamics Simulations of Closed and Open States of a Proton-gated Ion Channel

1. Anton Jansen
2. Paul Bauer
3. Rebecca J. Howard
4. Berk Hess
5. Erik Lindahl

Cellular lipids regulate the conformational ensembles of the disordered intracellular loop 3 in β2-adrenergic receptor

1. Elizaveta Mukhaleva
2. Tianyi Yang
3. Fredrik Sadler
4. Sivaraj Sivaramakrishnan
5. Ning Ma
6. Nagarajan Vaidehi

Structural analysis of the Sterile alpha motif (SAM) domain of the Arabidopsis mitochondrial tRNA import receptor

1. Bence Olasz
2. Luke Smithers
3. Genevieve L. Evans
4. Anandhi Anandan
5. Monika W. Murcha
6. Alice Vrielink

Tripartite interactions of PKA catalytic subunit and C-terminal domains of cardiac Ca ²⁺ channel modulate its β-adrenergic regulation

1. Shimrit Oz
2. Tom Sharon
3. Suraj Subramaniam
4. Tamara Pallien
5. Moshe Katz
6. Vladimir Tsemakhovich
7. Debi Ranjan Tripathy
8. Giorgia Sasson
9. Orna Chomsky-Hecht
10. Leonid Vysochek
11. Maike Schulz
12. Claudia Fecher-Trost
13. Kerstin Zühlke
14. Daniela Bertinetti
15. Friedrich W. Herberg
16. Tal Keren-Raifman
17. Veit Flockerzi
18. Joel A. Hirsch
19. Enno Klussmann
20. Sharon Weiss
21. Nathan Dascal

Allosteric competition and inhibition in AMPA receptors

1. W. Dylan Hale
2. Alejandra Montaño Romero
3. Cuauhtemoc U. Gonzalez
4. Vasanthi Jayaraman
5. Albert Y. Lau
6. Richard L. Huganir
7. Edward C. Twomey

Structure of transmembrane AMPA receptor regulatory protein subunit γ2

1. W. Dylan Hale
2. Alejandra Montaño Romero
3. Nicholas Koylass
4. Collin R. Warrick
5. Zhaozhu Qiu
6. Richard L. Huganir
7. Edward C. Twomey

Allosteric modulation of the CXCR4:CXCL12 axis by targeting receptor nanoclustering via the TMV-TMVI domain

1. Eva M García-Cuesta
2. Pablo Martínez
3. Karthik Selvaraju
4. Gabriel Ulltjärn
5. Adrián Miguel Gómez Pozo
6. Gianluca D'Agostino
7. Sofia Gardeta
8. Adriana Quijada-Freire
9. Patricia Blanco Gabella
10. Carlos Roca
11. Daniel del Hoyo
12. Rodrigo Jiménez-Saiz
13. Alfonso García-Rubia
14. Blanca Soler Palacios
15. Pilar Lucas
16. Rosa Ayala-Bueno
17. Noelia Santander Acerete
18. Yolanda Carrasco
19. Carlos Oscar Sorzano
20. Ana Martinez
21. Nuria E Campillo
22. Lasse D Jensen
23. Jose Miguel Rodriguez Frade
24. César Santiago
25. Mario Mellado

• Curated by eLife

  eLife assessment

  This is an important study that describes an elegant modelling driven approach to design of allosteric antagonists for CXCR4 that have a selective effect on receptor nanocluster formation, cell polarisation and chemotaxis, but spare binding of CXCL12 to the receptor and inhibition of adenylate cyclase. This enables selective targeting of processes dependent upon cell polarisation and chemotaxis without impacting signalling effects and may avoid some of the toxicity associated with antagonists that target CXCL12 binding and thus block all CXCR4 signalling. The revised manuscript offers convincing evidence to support the claims. The modelling work is better described and additional data has been presented that better illustrates the unique features of the new antagonist. The in vivo studies in the zebrafish model open a path to studies in mammalian models.

Reviewed by eLife

A cholesterol switch controls phospholipid scrambling by G protein–coupled receptors

1. Indu Menon
2. Taras Sych
3. Yeeun Son
4. Takefumi Morizumi
5. Joon Lee
6. Oliver P. Ernst
7. George Khelashvili
8. Erdinc Sezgin
9. Joshua Levitz
10. Anant K. Menon

Multiplexed mapping of the interactome of GPCRs with receptor activity–modifying proteins

1. Ilana B. Kotliar
2. Annika Bendes
3. Leo Dahl
4. Yuanhuang Chen
5. Marcus Saarinen
6. Emilie Ceraudo
7. Tea Dodig-Crnković
8. Mathias Uhlén
9. Per Svenningsson
10. Jochen M. Schwenk
11. Thomas P. Sakmar

The Sec61/TRAP Translocon Scrambles Lipids

1. Matti Javanainen
2. Sudeep Karki
3. Dale Tranter
4. Denys Biriukov
5. Ville O. Paavilainen

Reactive oxygen species generation by reverse electron transfer at mitochondrial complex I under simulated early reperfusion conditions

1. Caio Tabata Fukushima
2. Ian-Shika Dancil
3. Hannah Clary
4. Nidhi Shah
5. Sergiy M. Nadtochiy
6. Paul S. Brookes

Ion occupancy of the selectivity filter controls opening of a cytoplasmic gate in the K2P channel TALK-2

1. Lea C. Neelsen
2. Elena B. Riel
3. Susanne Rinné
4. Freya-Rebecca Schmid
5. Björn C. Jürs
6. Mauricio Bedoya
7. Jan P. Langer
8. Bisher Eymsh
9. Aytug K. Kiper
10. Sönke Cordeiro
11. Niels Decher
12. Thomas Baukrowitz
13. Marcus Schewe

Selective activation of intracellular β1AR using a spatially restricted antagonist

1. Federica Liccardo
2. Johannes Morstein
3. Ting-Yu Lin
4. Julius Pampel
5. Kevan M. Shokat
6. Roshanak Irannejad

Exploring TAS2R46 biomechanics through molecular dynamics and network analysis

1. Marco Cannariato
2. Riccardo Fanunza
3. Eric A. Zizzi
4. Marcello Miceli
5. Giacomo Di Benedetto
6. Marco A. Deriu
7. Lorenzo Pallante

Mechanisms of ligand recognition and activation of melanin-concentrating hormone receptors

1. Qian He
2. Qingning Yuan
3. Hong Shan
4. Canrong Wu
5. Yimin Gu
6. Kai Wu
7. Wen Hu
8. Yumu Zhang
9. Xinheng He
10. H. Eric Xu
11. Li-Hua Zhao

Ligand-Dependent Mechanisms of CC Chemokine Receptor 5 (CCR5) Trafficking Revealed by APEX2 Proximity Labeling Proteomics

1. Siyi Gu
2. Svetlana Maurya
3. Alexis Lona
4. Leire Borrega-Roman
5. Catherina Salanga
6. David J. Gonzalez
7. Irina Kufareva
8. Tracy M. Handel

Crystal structure of the GluK1 ligand-binding domain with kainate and the full-spanning positive allosteric modulator BPAM538

1. Yasmin Bay
2. Federico Javier Miguez Cabello
3. Chloe C. Koens
4. Stine M. Frantsen
5. Darryl S. Pickering
6. Karla Frydenvang
7. Pierre Francotte
8. Bernard Pirotte
9. Anders S. Kristensen
10. Derek Bowie
11. Jette Sandholm Kastrup

Pathogenicity Prediction of GABA _A Receptor Missense Variants

1. Ya‐Juan Wang
2. Giang H. Vu
3. Ting‐Wei Mu

Water inside the Selectivity Filter of a K ⁺ Ion Channel: Structural Heterogeneity, Picosecond Dynamics, and Hydrogen Bonding

1. Matthew J. Ryan
2. Lujia Gao
3. Francis I. Valiyaveetil
4. Alexei A. Kananenka
5. Martin T. Zanni