Reading List

Discovering cryptic pocket opening and binding of a stimulant derivative in a vestibular site of the 5-HT _{3 A} receptor

1. Nandan Haloi
2. Emelia Karlsson
3. Marc Delarue
4. Rebecca J. Howard
5. Erik Lindahl

Unraveling activation-related rearrangements and intrinsic divergence from ligand-induced conformational changes of the dopamine D3 and D2 receptors

1. Kuo Hao Lee
2. Lei Shi

Electronic Polarizability Tunes the Function of the Human Bestrophin 1 Cl ^– Channel

1. Linda X. Phan
2. Aaron P. Owji
3. Tingting Yang
4. Jason Crain
5. Mark S.P. Sansom
6. Stephen J. Tucker

The pathogenic p.N1662D SCN2A mutation reveals an essential molecular interaction for Na _v 1.2 channel inactivation

1. Géza Berecki
2. Elaine Tao
3. Katherine B. Howell
4. Rohini K. Coorg
5. Kris Kahlig
6. Markus Wolff
7. Ben Corry
8. Steven Petrou

Structural determinants of the direct inhibition of GIRK channels by Sigma-1 receptor antagonist

1. Chang Liu
2. I-Shan Chen
3. Michihiro Tateyama
4. Yoshihiro Kubo

Mechanistic basis of the dynamic response of TWIK1 ionic selectivity to pH

1. Franck C. Chatelain
2. Nicolas Gilbert
3. Delphine Bichet
4. Annaïse Jauch
5. Sylvain Feliciangeli
6. Florian Lesage
7. Olivier Bignucolo

Conformational diversity in class C GPCR positive allosteric modulation

1. Giuseppe Cannone
2. Ludovic Berto
3. Fanny Malhaire
4. Gavin Ferguson
5. Aurelien Fouillen
6. Stéphanie Balor
7. Joan Font-Ingles
8. Amadeu Llebaria
9. Cyril Goudet
10. Abhay Kotecha
11. Vinothkumar K.R.
12. Guillaume Lebon

Molecular dynamics simulation analysis of structural dynamic cross correlation induced by odorant hydrogen-bonding in mouse eugenol ol- factory receptor

1. Chisato Okamoto
2. Koji Ando

GABAA receptor subunit M2-M3 linkers have asymmetric roles in pore gating and diazepam modulation

1. Joseph W. Nors
2. Zachary Endres
3. Marcel P. Goldschen-Ohm

Cryo-EM structure of Slo1 with the auxiliary γ1 subunit suggests mechanism of depolarization-independent activation

1. Milena Redhardt
2. Stefan Raunser
3. Tobias Raisch

Reviewed by Review Commons

Characterisation of ligand gating, ion conduction and the ion selectivity mechanism in the endo-lysosomal ion channel hTPC2

1. Alp Tegin Şahin
2. Ulrich Zachariae

From Average Transient Transporter Currents to Microscopic Mechanism─A Bayesian Analysis

1. August George
2. Daniel M. Zuckerman

Distinct activation mechanisms of CXCR4 and ACKR3 revealed by single-molecule analysis of their conformational landscapes

1. Christopher T Schafer
2. Raymond F Pauszek
3. Martin Gustavsson
4. Tracy M Handel
5. David P Millar

• Curated by eLife

  eLife Assessment

  This manuscript describes the characterization of the conformational dynamics of two chemokine receptors at the single-molecule level using FRET. The authors make a convincing case for attributing the distinct interaction and pharmacology of the two receptors to differences in their conformational energy landscape. These important findings will be of interest to scientists working on activation mechanisms of GPCRs and signal transduction.

Reviewed by eLife

Transport and inhibition mechanism for VMAT2-mediated synaptic loading of monoamines

1. Yuwei Wang
2. Pei Zhang
3. Yulin Chao
4. Zhini Zhu
5. Chuanhui Yang
6. Zixuan Zhou
7. Yaohui Li
8. Yonghui Long
9. Yuehua Liu
10. Dianfan Li
11. Sheng Wang
12. Qianhui Qu

Radical pair model for magnetic field effects on NMDA receptor activity

1. Parvathy S. Nair
2. Hadi Zadeh-Haghighi
3. Christoph Simon

A time-resolved Förster resonance energy transfer assay to investigate inhibitor binding to ABCG2

1. James I. Mitchell-White
2. Deborah A. Briggs
3. Sarah J. Mistry
4. Hannah A Mbiwan
5. Barrie Kellam
6. Nicholas D. Holliday
7. Stephen J. Briddon
8. Ian D. Kerr

WITHDRAWN: Conformational Dynamics and Ligand Binding of the Human Voltage-Gated Proton Channel

1. Xiaoyu Sun
2. Xue Mo
3. Zhi Ruan
4. Wen Chen

How much does TRPV1 deviate from an ideal MWC-type protein?

1. Shisheng Li
2. Jie Zheng

Accelerated Molecular Dynamics and AlphaFold Uncover a Missing Conformational State of Transporter Protein OxlT

1. Jun Ohnuki
2. Titouan Jaunet-Lahary
3. Atsuko Yamashita
4. Kei-ichi Okazaki

Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation

1. Karin E. J. Rödström
2. Alexander Cloake
3. Janina Sörmann
4. Agnese Baronina
5. Kathryn H. M. Smith
6. Ashley C. W. Pike
7. Jackie Ang
8. Peter Proks
9. Marcus Schewe
10. Ingelise Holland-Kaye
11. Simon R. Bushell
12. Jenna Elliott
13. Els Pardon
14. Thomas Baukrowitz
15. Raymond J. Owens
16. Simon Newstead
17. Jan Steyaert
18. Elisabeth P. Carpenter
19. Stephen J. Tucker