Reading List

Structure of the lens MP20 mediated adhesive junction

1. William J. Nicolas
2. Anna Shiriaeva
3. Michael W. Martynowycz
4. Angus C. Grey
5. Yasmeen N. Ruma
6. Paul J. Donaldson
7. Tamir Gonen

Subunit positioning and diversity of the nematode levamisole-sensitive acetylcholine receptor

1. JD Noonan
2. TB Duguet
3. CJ Handy-Hart
4. RN Beech

Fluorescence labeling strategies for cell surface expression of TRPV1

1. Taylor M. Mott
2. Grace C. Wulffraat
3. Alex J. Eddins
4. Ryan A. Mehl
5. Eric N. Senning

The Mycobacterium lipid transporter MmpL3 is dimeric in detergent solution, SMALPs and reconstituted nanodiscs

1. Sara Cioccolo
2. Joseph D. Barritt
3. Naomi Pollock
4. Zoe Hall
5. Julia Babuta
6. Pooja Sridhar
7. Alicia Just
8. Nina Morgner
9. Tim Dafforn
10. Ian Gould
11. Bernadette Byrne

Structures of native SV2A reveal the binding mode for tetanus neurotoxin and anti-epileptic racetams

1. Stephan Schenck
2. Toon Laeremans
3. Jan Steyaert
4. Janine D. Brunner

PfHT1 controls glucose uptake in malaria parasite: molecular dynamics study in plasma membrane like environment reveals ligand induced conformational changes trigger closed conformation and alters binding pocket geometry

1. Manisha Ganguly
2. Hriddhi Maitra
3. Amlan Roychowdhury
4. Ditipriya Hazra

Protein interactions, calcium, phosphorylation, and cholesterol modulate CFTR cluster formation on membranes

1. Yimei Wan
2. Rhea Hudson
3. Jordyn Smith
4. Julie D. Forman-Kay
5. Jonathon A. Ditlev

Vestibular modulation by stimulant derivatives in a pentameric ligand‐gated ion channel

1. Emelia Karlsson
2. Olivia Andén
3. Chen Fan
4. Zaineb Fourati
5. Ahmed Haouz
6. Yuxuan Zhuang
7. Rebecca J. Howard
8. Marc Delarue
9. Erik Lindahl

Adaptive sampling-based structural prediction reveals opening of a GABA _A receptor through the αβ interface

1. Nandan Haloi
2. Rebecca J. Howard
3. Erik Lindahl

Computational modelling of specific serotonin reuptake inhibitor inhibition on the TREK-2 channel

1. Narawit Pratueangsukpong
2. Tanadet Pipatpolkai

Deep Mutagenesis of a Transporter for Uptake of a Non-Native Substrate Identifies Conformationally Dynamic Regions

1. Heather J Ellis
2. Matthew Chan
3. Balaji Selvam
4. Evan Walter
5. Christine A Devlin
6. Steven K Szymanski
7. Loren Keith Henry
8. Diwakar Shukla
9. Erik Procko

• Curated by eLife

  eLife assessment

  Serotonin is an important neurotransmitter and its synaptic concentration is controlled by re-uptake by the sodium-coupled serotonin transporter SERT. The manuscript by Chan et al reports results from a systematic deep mutagenesis approach to study the surface expression and APP+ (5HT analogue) transport mechanism of the human serotonin transporter. The authors complement this experimental evidence with large-scale molecular simulations of the transporter in the presence of APP+. The use of deep mutagenesis and large-scale adaptive sampling simulations is impressive, and could contribute to understanding the structural requirements for folding and how transporters evolve to recognize different substrates.

Reviewed by eLife

Unveiling the crucial role of betaine: Modulation of GABA homeostasis via SLC6A1 transporter (GAT1)

1. Manan Bhatt
2. Erika Lazzarin
3. Ana Sofia Alberto-Silva
4. Guido Domingo
5. Rocco Zerlotti
6. Ralph Gradisch
7. Andre Bazzone
8. Harald H. Sitte
9. Thomas Stockner
10. Elena Bossi

On the function of TRAP substrate-binding proteins: Conformational variation of the sialic acid binding protein SiaP

1. Te-Rina J. King-Hudson
2. James S. Davies
3. Senwei Quan
4. Michael J. Currie
5. Zachary D. Tillett
6. Jack Copping
7. Santosh Panjikar
8. Rosmarie Friemann
9. Jane R. Allison
10. Rachel A. North
11. Renwick C.J. Dobson

Energetics of substrate transport in proton-dependent oligopeptide transporters

1. Balaji Selvam
2. Nicole Chiang
3. Diwakar Shukla

Optimal experimental designs for characterising ion channel gating by filling the phase-voltage space of model dynamics

1. Gary R. Mirams
2. Michael Clerx
3. Dominic G. Whittaker
4. Chon Lok Lei

T2R14 mediated antimicrobial responses through interactions with CFTR

1. Tejas Gupte
2. Nisha Singh
3. Vikram Bhatia
4. Kavisha Arora
5. Shayan Amiri
6. Paul Fernhyhough
7. Anjaparavanda P Naren
8. Shyamala Dakshinamurti
9. Prashen Chelikani

A key residue of the extracellular gate provides quality control contributing to ABCG substrate specificity

1. Jian Xia
2. Alexandra Siffert
3. Odalys Torres
4. Francesca Iacobini
5. Joanna Banasiak
6. Konrad Pakuła
7. Jörg Ziegler
8. Sabine Rosahl
9. Noel Ferro
10. Michał Jasiński
11. Tamás Hegedűs
12. Markus M. Geisler

A Futile Cycle? Tissue Homeostatic Trans-Membrane Water Co-Transport: Kinetics, Thermodynamics, Metabolic Consequences

1. Charles S. Springer
2. Martin M. Pike
3. Thomas M. Barbara