Reading List

Membrane phosphoinositides allosterically tune β-arrestin dynamics to facilitate GPCR core engagement

1. John Janetzko
2. Jonathan Deutsch
3. Yuqi Shi
4. Dirk H. Siepe
5. Matthieu Masureel
6. Weijing Liu
7. Rosa Viner
8. Asuka Inoue
9. Steven Chu
10. Brian K. Kobilka
11. Rabindra V. Shivnaraine

The structural basis of cold sensitivity

1. Kevin Y. Choi
2. Xiaoxuan Lin
3. Yifan Cheng
4. David Julius

Mechanisms of KCNQ1 gating modulation by KCNE1/3 for cell-specific function

1. Chenxi Cui
2. Lu Zhao
3. Ali A. Kermani
4. Shuzong Du
5. Tanadet Pipatpolkai
6. Meiqin Jiang
7. Sagar Chittori
8. Yong Zi Tan
9. Jingyi Shi
10. Lucie Delemotte
11. Jianmin Cui
12. Ji Sun

Correlating membrane-protein dynamics with function: Integrating bioinformatics, molecular dynamics, and single-molecule FRET

1. Hugh R. Higinbotham
2. Christine A. Arbour
3. Barbara Imperiali

Mechanism of Lipid-Dependent Thermosensation in an Ion Channel

1. Chieh-Chin Li
2. Crina M. Nimigean

Programmed inhibition of an innate immune receptor via de novo designed transmembrane proteins

1. Colleen A. Maillie
2. Minghao Zhang
3. Nadia Gosiet
4. George Goldenfeld
5. Andrew B. Ward
6. Marco Mravic

Non-Equilibrium Snapshots of Ligand Efficacy at the μ-Opioid Receptor

1. Michael J. Robertson
2. Makaía M. Papasergi-Scott
3. Maria Claudia Peroto
4. Balazs R. Varga
5. Susruta Majumdar
6. Georgios Skiniotis

The genetic architecture of G-protein coupled receptor signaling

1. Taylor L. Mighell
2. Ben Lehner

The Na ⁺ -pumping mechanism driven by redox reactions in the NADH-quinone oxidoreductase from Vibrio cholerae relies on dynamic conformational changes

1. Moe Ishikawa-Fukuda
2. Takehito Seki
3. Jun-ichi Kishikawa
4. Masuya Takahiro
5. Kei-ichi Okazaki
6. Takayuki Kato
7. Blanca Barquera
8. Hideto Miyoshi
9. Masatoshi Murai

Off-Target Structural Insights: ArnA and AcrB in Bacterial Membrane Protein Cryo-EM Analysis

1. Mehmet Caliseki
2. Ufuk Borucu
3. Sathish K. N. Yadav
4. Christiane Schaffitzel
5. Burak Veli Kabasakal

FDA drug repurposing uncovers modulators of dopamine D2 receptor localization via disruption of the NCS-1 interaction

1. Daniel Muñoz-Reyes
2. Lorena Aguado
3. Sandra Arroyo-Urea
4. Carlos Requena
5. Sara Perez-Suarez
6. Sonia Sanchez-Yepes
7. Josep Argerich
8. Celia Miro-Rodriguez
9. Eugenia Ulzurrun
10. Eulalia Rodriguez
11. Javier Garcia-Nafria
12. Nuria E Campillo
13. Alicia Mansilla
14. Maria Jose Sanchez-Barrena

Functional Implications of the Conformational Landscape of a Multidrug Transporter Revealed by Structures of Zebrafish Abcb4

1. Jingyu Zhan
2. Chao-Ming Hsieh
3. Lothar Esser
4. Zabrina C. Lang
5. Abraham J Morton
6. Robert Robey
7. Fei Zhou
8. Suresh V. Ambudkar
9. Rick K. Huang
10. Michael M. Gottesman
11. Di Xia

Angiotensin receptor conformations stabilized by biased ligands differentially modulate β-arrestin interactions

1. Matthias Elgeti
2. Julia Belyaeva
3. Mahdi Bagherpoor Helabad
4. Dean P. Staus
5. Laura M. Wingler

Mechanism of SK2 channel gating and its modulation by the bee toxin apamin and small molecules

1. Samantha J Cassell
2. Weiyan Li
3. Simon Krautwald
4. Maryam Khoshouei
5. Yan Tony Lee
6. Joyce Hou
7. Wendy Guan
8. Stefan Peukert
9. Wilhelm A Weihofen
10. Jonathan R Whicher

• Curated by eLife

  eLife Assessment

  In this important manuscript, Cassell and colleagues set out on a mechanistic and pharmacological exploration of an engineered chimeric small conductance calcium-activated potassium channel 2 (SK2). They show convincing evidence that the SK2 channel possesses a unique extracellular structure that modulates the conductivity of the selectivity filter, and that this structure is the target for the SK2 inhibitor apamin. While the interpretations are sound and the writing is clear, the manuscript would be strengthened by providing more detailed information for the electrophysiological experiments and the structural analyses attempted, in addition to relating dilation of the filter to mechanisms of inactivation in other potassium channels. This high-quality study will be of interest to membrane protein structural biologists, ion channel biophysicists, and chemical biologists, and will inform future drug development targeting SK channels.

Reviewed by eLife

Molecular fingerprints of a convergent mechanism orchestrating diverse ligand recognition and species-specific pharmacology at the complement anaphylatoxin receptors

1. Sudha Mishra
2. Manish K. Yadav
3. Annu Dalal
4. Manisankar Ganguly
5. Ravi Yadav
6. Kazuhiro Sawada
7. Divyanshu Tiwari
8. Nabarun Roy
9. Nilanjana Banerjee
10. Jenny N. Fung
11. Jianina Marallag
12. Cedric S. Cui
13. Xaria X. Li
14. John D. Lee
15. Calvin Aaron Dsouza
16. Shirsha Saha
17. Parishmita Sarma
18. Ganita Rawat
19. Houming Zhu
20. Htet A. Khant
21. Richard J. Clark
22. Fumiya K. Sano
23. Ramanuj Banerjee
24. Trent M. Woodruff
25. Osamu Nureki
26. Cornelius Gati
27. Arun K. Shukla

Antibiotics-induced conformational heterogeneity of a multidrug transporter revealed by single-molecule FRET

1. Hassan Maklad
2. Tom Kache
3. Aurélie Roth
4. Maria Mamkaeva
5. Cédric Govaerts
6. Jelle Hendrix
7. Chloé Martens

Lipid gating of BK channels and mechanism of activation by negatively charged lipids

1. Andrei Mironenko
2. Bert L. de Groot
3. Wojciech Kopec

Structure-function analysis of lithium-ion selectivity of voltage-gated sodium channel

1. Yuki K. Maeda
2. Kentaro Kojima
3. Tomoe Y. Nakamura
4. Toru Nakatsu
5. Katsumasa Irie

Molecular Basis of Sodium Channel Inactivation

1. Francisco Bezanilla
2. Yichen Liu
3. Jason Galpin
4. Christopher Ahern

Molecular mechanism of substrate transport by human peroxisomal ABCD3

1. Meghna Gupta
2. Nitesh Kumar Khandelwal
3. Devin J. Seka
4. Sree Ganesh Balasubramani
5. Miles Sasha Dickinson
6. Alexander Myasnikov
7. Ignacia Echeverria
8. Robert M. Stroud