Reading List

Structural and dynamic studies uncover a distinct allosteric modulatory site at the μ-opioid receptor

1. Haonan Zhang
2. Kirill Konovalov
3. Alexandra K. Parpounas
4. Davide Provasi
5. Shifan Yang
6. Alejandro Abraham
7. Audrey L. Warren
8. Gregory Zilberg
9. Suri Wang
10. Marta Filizola
11. Daniel Wacker

Lipid composition and mechanical force underlie multi-modal regulation of Piezo1 gating

1. George Vaisey
2. Roderick MacKinnon

Interrogating the structure and function of the human voltage-gated proton channel (hHv1) with a fluorescent noncanonical amino acid

1. Emerson M Carmona
2. William N Zagotta
3. Sharona E Gordon

• Curated by eLife

  eLife Assessment

  This important study presents a convincing methodological approach to probe the structural features of the full-length human Hv1 channel as a purified protein. The method is supported by rigorous biochemical assays and spectral FRET analysis, which will interest biophysicists and physiologists studying Hv1 and other ion channels and membrane proteins. Overall, the work introduces an interesting labeling strategy and provides a methodology that is of value in investigating hHV1 in particular and can be extended to other ion channels. The authors also provide preliminary observations regarding conformational changes induced by zinc.

Reviewed by eLife

Selectivity Filter Dynamics Define Ion Conductance and Selectivity Differences in CNG and HCN Channels

1. Haoran Liu
2. Klaus Benndorf
3. Yessenbek K. Aldakul
4. Han Sun

A biased allosteric modulator functions as a molecular glue to induce β ₂ AR dimerization

1. Jiemin Shen
2. Teja Nikhil Peddada
3. Konstantin E. Komolov
4. Francesco De Pascali
5. Alexander M. Garces
6. Haoqing Wang
7. Michael T. Lerch
8. Jeffrey L. Benovic
9. Jun Xu
10. Brian K. Kobilka

Cryo-EM Structures of Methanogenic Schizorhodopsins Reveal Divergent Strategies for Proton Transport and Thermal Adaptation

1. Iota Ebisu
2. Tatsuki Tanaka
3. Yuma Kawasaki
4. Shunya Murakoshi
5. Keisei Shibata
6. Yoshitaka Kato
7. Masae Konno
8. Wataru Shihoya
9. Keiichi Inoue
10. Osamu Nureki

Autoregulation of the MET Receptor Tyrosine Kinase by its Intracellular Juxtamembrane Domain

1. Edmond M. Linossi
2. Carla A. Espinoza
3. Gabriella O. Estevam
4. James S. Fraser
5. Natalia Jura

The bacterial schizorhodopsins: novel light-driven inward proton pumps from Antarctic Minisyncoccota (Patescibacteria) and cyanobacteria, with implications for the proton-pumping mechanism

1. María del Carmen Marín
2. Masae Konno
3. Andrey Rozenberg
4. Oded Béjà
5. Labinoue Inoue

Structure based discovery of antipsychotic-like TAAR1 agonists

1. Sijie Huang
2. Heng Liu
3. Yujin Wu
4. Joao M. Braz
5. Divya Kranthi
6. Brendan W. Hall
7. Xinyue Zhang
8. Dmytro S. Radchenko
9. Yurii S. Moroz
10. John J. Irwin
11. Allan I. Basbaum
12. H. Eric Xu
13. William C. Wetsel
14. Brian K. Shoichet

A single residue determines regulation of TRPV1 by phosphoinositides

1. Benjamin He
2. Prateeti Varanasi
3. Nia M. Barkum
4. Rose Hudson
5. Eric N. Senning

Homeostatic regulation of intrinsic lipid curvature in eukaryotic cells

1. Daniel Milshteyn
2. Jacob R. Winnikoff
3. Elida Kocharian
4. Aaron M. Armando
5. Edward A. Dennis
6. Peter R. Girguis
7. Itay Budin

High Throughput Screening Identifies a Small Molecule Trafficking Corrector for Long-QT Syndrome Associated KCNQ1 Variants

1. Katherine R. Clowes Moster
2. Carlos G. Vanoye
3. Ana C Chang-Gonzalez
4. Ian M. Romaine
5. Katherine M. Stefanski
6. Mason C. Wilkinson
7. Joshua A. Bauer
8. Thomas P. Hasaka
9. Emily L. Days
10. Reshma Desai
11. Kathryn R. Butcher
12. Gary A. Sulikowksi
13. Alex G. Waterson
14. Jens Meiler
15. Kaitlyn Ledwitch
16. Alfred L George
17. Charles R. Sanders

Asymmetric phosphoinositide lipid bilayers generated by spontaneous lipid insertion

1. Gwendal Guerin
2. Thi Lan Anh Nguyen
3. John Manzi
4. Christophe Le Clainche
5. Julien Heuvingh
6. Julien Berro
7. Nicolas Rodriguez
8. Sophie Cribier
9. Feng-Ching Tsai

Structural basis for gating inhibition by the cytoplasmic domain in HCN1 channels

1. V. Zorzini
2. J.M. Kleiz-Ferreira
3. M. Brams
4. R. Gallardo
5. S. De Gieter
6. J. Kusch
7. C. Ulens

Clustering of SARS-CoV-2 membrane proteins in lipid bilayer membranes

1. Joseph McTiernan
2. Yuanzhong Zhang
3. Siyu Li
4. Thomas E. Kuhlman
5. Umar Mohideen
6. Michael E. Colvin
7. Roya Zandi
8. Ajay Gopinathan

Mechanistic Insights into the Structural Asymmetry of the LanFEG Transporter NisFEG in Lantibiotic Immunity

1. Pablo A. Cea
2. Julia Gottstein
3. Sander H.J. Smits
4. Holger Gohlke

Engineering substrate selectivity in the human sodium/iodide symporter (NIS)

1. Alejandro Llorente-Esteban
2. Haswitha Sabbineni
3. Kendra Hoffsmith
4. Rían W. Manville
5. David López-González
6. Andrea Reyna-Neyra
7. J. Alfonso Leyva
8. Geoffrey W. Abbott
9. Mario A. Bianchet
10. Nancy Carrasco

Nanobody-Driven Stabilization Synergistically Rescues F508del-CFTR and Reveals an Alternative Active State of the Channel

1. Marie Overtus
2. Tihomir Rubil
3. James N. Charlick
4. Andrew S. Paige
5. Blaine J. Loughlin
6. Zachary Rich
7. Mayuree Rodrat
8. Zhengrong Yang
9. Anita Balázs
10. John C. Kappes
11. Marcus A. Mall
12. David N. Sheppard
13. John F. Hunt
14. Cédric Govaerts

Unconventional Fusion Mechanism at the Origin of Eukaryotic Membranes

1. Maria L. Mascotti
2. Luis S. Mayorga
3. Diego Masone

A bi-directional binding site linking the α ₂ δ-1 subunit to the intrinsic speed control process in VSD I of voltage-gated calcium channels

1. Martin C. Heiss
2. Monica L. Fernández-Quintero
3. Nicole Kranbitter
4. Hajar El Aouad
5. Marta Campiglio
6. Bernhard E. Flucher