Reading list

Temperature Sensitive Glutamate Gating of AMPA-subtype iGluRs

1. Anish Kumar Mondal
2. Elisa Carrillo
3. Vasanthi Jayaraman
4. Edward C. Twomey

Resolving the conformational ensemble of a membrane protein by integrating small-angle scattering with AlphaFold

1. Samuel Eriksson Lidbrink
2. Rebecca Howard
3. Nandan Haloi
4. Erik Lindahl

AI-Based Discovery and CryoEM Structural Elucidation of a KATP Channel Pharmacochaperone

1. Assmaa ElSheikh
2. Camden M Driggers
3. Ha H Truong
4. Zhongying Yang
5. John Allen
6. Niel Henriksen
7. Katarzyna Walczewska-Szewc
8. Show-Ling Shyng

• Curated by eLife

  eLife Assessment

  This important study demonstrates that screening by artificial intelligence can identify relevant novel compounds for interacting with KATP channels. The experimental work is compelling. The broader significance of this work relates to the possibility that KATP channel mutations linked to congenital hyperinsulinism may be effectively rescued to the cell surface with a drug, which could normalize insulin secretion or enhance the effectiveness of existing KATP channel activators such as diazoxide.

Reviewed by eLife

LPA ₃ receptors have orthosteric and allosteric binding sites evidenced under docking studies

1. K. Helivier Solís
2. M. Teresa Romero-Ávila
3. Ruth Rincón-Heredia
4. José Correa-Basurto
5. J. Adolfo García-Sáinz

Transport of herbicides by PIN-FORMED auxin transporters

1. Lukas Schulz
2. Kien Lam Ung
3. Sarah Koutnik-Abele
4. David L Stokes
5. Bjørn Panyella Pedersen
6. Ulrich Z. Hammes

Molecular Insights into Single Chain Lipid Modulation of Acid-Sensing Ion Channel 3

1. Ramya Bandarupalli
2. Rebecca Roth
3. Robert C Klipp
4. John R Bankston
5. Jing Li

Reviewed by Arcadia Science

Structural basis of inhibition of human Na _V 1.8 by the tarantula venom peptide Protoxin-I

1. Bryan Neumann
2. Stephen McCarthy
3. Shane Gonen

Diarylamidine activation of a brachiopod DEG/ENaC/ASIC channel

1. Josep Martí-Solans
2. Aina Børve
3. Andreas Hejnol
4. Timothy Lynagh

Basis of Glucose and Fructose Selectivity in Sugar Transport Proteins

1. Camilla Gottlieb Andersen
2. Laust Bavnhøj
3. Søren Brag
4. Jan Heiner Driller
5. Bjørn Panyella Pedersen

High-resolution structures of the UapA purine transporter reveal unprecedented aspects of the elevator-type transport mechanism

1. George Broutzakis
2. Yiannis Pyrris
3. Ifigeneia Akrani
4. Alexander Neuhaus
5. Emmanuel Mikros
6. George Diallinas
7. Christos Gatsogiannis

Mammalian PIEZO channels rectify anionic currents

1. Tharaka D. Wijerathne
2. Aashish Bhatt
3. Wenjuan Jiang
4. Yun Lyna Luo
5. Jerome J. Lacroix

Structural basis of phosphate export by human XPR1

1. Qixian He
2. Ran Zhang
3. Sandrine Tury
4. Valerie Courgnaud
5. Fenglian Liu
6. Jean-luc Battini
7. Baobin Li
8. Qingfeng Chen

Atomic-Level Free Energy Landscape Reveals Cooperative Symport Mechanism of Melibiose Transporter

1. Ruibin Liang
2. Lan Guan

• Curated by eLife

  eLife Assessment

  In this potentially important study, the authors employed advanced computational techniques to explore a detailed atomistic description of the mechanism and energetics of substrate translocation in the MelB transporter. The overall approach is solid and reveals the coupling between sodium binding and melibiose transport through a series of conformational transitions, and the results for a mutant are also in qualitative agreement with the experiment, providing further support to the computational analyses. Nevertheless, the level of evidence is considered incomplete since there are concerns regarding the convergence and initial guess of the string calculations, leaving doubts that the computed pathway does not reflect the most energetically favorable mechanism.

Reviewed by eLife

Structures of Multiple Peptide Resistance Factor from Pseudomonas aeruginosa

1. Shaileshanand Jha
2. Kutti R. Vinothkumar

MAASTY: A (dis)ordered copolymer for structural determination of human membrane proteins in native nanodiscs

1. Ciara Frances Pugh
2. Kaia Fiil Præstegaard
3. Lukas Peter Feilen
4. Dušan Živković
5. Neil Jean Borthwick
6. Casper de Lichtenberg
7. Jani R. Bolla
8. Anton Allen Abbotsford Autzen
9. Henriette Elisabeth Autzen

Finding the E-Channel Proton Loading Sites by Calculating the Ensemble of Protonation Microstates

1. Md. Raihan Uddin
2. Umesh Khaniya
3. Chitrak Gupta
4. Junjun Mao
5. Gehan Ranepura
6. Rongmei Wei
7. Jose Ortiz Soto
8. Abhishek Singharoy
9. Marilyn Gunner

Nernst Equilibrium, Rectification, and Saturation: Insights into Ion Channel Behavior

1. Ryan Carlsen
2. Hannah Weckel-Dahman
3. Jessica MJ Swanson

A range of voltage-clamp protocol designs for rapid capture of hERG kinetics

1. Chon Lok Lei
2. Dominic G Whittaker
3. Monique J Windley
4. Matthew D Perry
5. Adam P Hill
6. Gary R Mirams

Functional investigation of a putative calcium-binding site involved in the inhibition of inositol 1,4,5-trisphosphate receptor activity

1. Vikas Arige
2. Larry E. Wagner
3. Sundeep Malik
4. Mariah R. Baker
5. Guizhen Fan
6. Irina I. Serysheva
7. David I. Yule

Aerolysin nanopore structure revealed at high resolution in lipid environment

1. Jana S. Anton
2. Ioan Iacovache
3. Juan F. Bada Juarez
4. Luciano A. Abriata
5. Louis W. Perrin
6. Chan Cao
7. Maria J. Marcaida
8. Benoit Zuber
9. Matteo Dal Peraro