Reading list

Structural insight into binding site access and ligand recognition by human ABCB1

1. Devanshu Kurre
2. Phuoc X. Dang
3. Le T.M. Le
4. Varun V. Gadkari
5. Amer Alam

Calculation of minimum energy pathways in transport proteins

1. Briony A Yorke
2. Helen M Ginn

Generating Multi-state Conformations of P-type ATPases with a Conditional Diffusion Model

1. Jingtian Xu
2. Yong Wang

Structure and function of the human apoptotic scramblase Xkr4

1. Sayan Chakraborty
2. Zhang Feng
3. Sangyun Lee
4. Omar E. Alvarenga
5. Aniruddha Panda
6. Renato Bruni
7. George Khelashvili
8. Kallol Gupta
9. Alessio Accardi

Turning a Kv channel into hot and cold receptor by perturbing its electromechanical coupling

1. Bernardo I Pinto-Anwandter
2. Carlos A Z Bassetto
3. Ramon Latorre
4. Francisco Bezanilla

Structures of TASK-1 and TASK-3 K2P channels provide insight into their gating and dysfunction in disease

1. Peter-Rory Hall
2. Thibault Jouen-Tachoire
3. Marcus Schewe
4. Peter Proks
5. Thomas Baukrowitz
6. Elisabeth P. Carpenter
7. Simon Newstead
8. Karin E.J. Rödström
9. Stephen J Tucker

Structure-based mechanism of RyR channel operation by calcium and magnesium ions

1. Alexandra Zahradníková
2. Jana Pavelková
3. Miroslav Sabo
4. Sefer Baday
5. Ivan Zahradník

Gz Enhanced Signal Transduction assaY (G _Z ESTY) for GPCR deorphanization

1. Luca Franchini
2. Joseph J. Porter
3. John D. Lueck
4. Cesare Orlandi

Human P2X4 receptor gating is modulated by a stable cytoplasmic cap and a unique allosteric pocket

1. Haoyuan Shi
2. Ismayn A. Ditter
3. Adam C. Oken
4. Steven E. Mansoor

Cryo-EM structures of ρ1 GABA _A receptors with antagonist and agonist drugs

1. Chen Fan
2. John Cowgill
3. Rebecca J. Howard
4. Erik Lindahl

Sensing endogenous RNA in living human cells using a CRISPR-activated protease

1. Katja Blumenstock
2. Alexander Hoch
3. Leo D. Hinterlang
4. Caroline I. Fandrey
5. Niels Schneberger
6. Gregor Hagelueken
7. Jonathan L. Schmid-Burgk

Deep learning guided design of dynamic proteins

1. Amy B. Guo
2. Deniz Akpinaroglu
3. Mark J.S. Kelly
4. Tanja Kortemme

Mechanistic insights from the atomic-level quaternary structure of short-lived GPCR oligomers in live cells

1. Valerica Raicu
2. Michael Stoneman
3. Koki Yokoi
4. Gabriel Biener
5. Thomas Killeen
6. Dhruba Adhikari
7. Sadia Rahman
8. Kaleeckal Harikumar
9. Laurence Miller

Competitive modulation of Kv1.2 gating by LMAN2 and Slc7a5

1. Damayantee Das
2. Shawn M. Lamothe
3. Anson Wong
4. Victoria A. Baronas
5. Harley T. Kurata

Activation of the influenza B M2 proton channel (BM2)

1. Zhi Yue
2. Jiangbo Wu
3. Da Teng
4. Zhi Wang
5. Gregory A Voth

A universal cannabinoid CB1 and CB2 receptor TR-FRET kinetic ligand binding assay

1. Leire Borrega-Roman
2. Bradley L. Hoare
3. Miroslav Kosar
4. Roman C. Sarott
5. Kacper J. Patej
6. Jara Bouma
7. Morgan Scott-Dennis
8. Eline J. Koers
9. Thais Gazzi
10. Leonard Mach
11. Sergio Barrondo
12. Joan Sallés
13. Wolfgang Guba
14. Eric Kusznir
15. Marc Nazaré
16. Arne C. Rufer
17. Uwe Grether
18. Laura H. Heitman
19. Erick M. Carreira
20. David A. Sykes
21. Dmitry B. Veprintsev

The N-terminal PAS domain directly regulates hERG channel gating in excised, inside-out patch-clamp fluorometry (PCF) recordings

1. Matthew C. Trudeau

Distinct mechanisms of inhibition of Kv2 potassium channels by tetraethylammonium and RY785

1. Shan Zhang
2. Robyn Stix
3. Esam A Orabi
4. Nathan Bernhardt
5. José D Faraldo-Gómez

• Curated by eLife

  eLife Assessment

  This study represents an important advance in our understanding of how certain inhibitors affect the behavior of voltage gated potassium channels. Robust molecular dynamics simulation and analysis methods lead to a new proposed inhibition mechanism with strength of support being mostly convincing, and incomplete in some aspects. This study has considerable significance for the fields of ion channel physiology and pharmacology and could aid in development of selective inhibitors for protein targets.

Reviewed by eLife

Single-molecule detection of transient dimerization of opioid receptors 2: Heterodimer blockage reduces morphine tolerance

1. Peng Zhou
2. Rinshi S. Kasai
3. Wakako Fujita
4. Taka A. Tsunoyama
5. Hiroshi Ueda
6. Simone Pigolotti
7. Takahiro K. Fujiwara
8. Akihiro Kusumi

Modeling Alternative Conformational States of Pseudo-Symmetric Solute Carrier Transporters using Methods from Machine Learning

1. G.V.T. Swapna
2. Namita Dube
3. Monica J. Roth
4. Gaetano T. Montelione