Reading List

T2R14 mediated antimicrobial responses through interactions with CFTR

1. Tejas Gupte
2. Nisha Singh
3. Vikram Bhatia
4. Kavisha Arora
5. Shayan Amiri
6. Paul Fernhyhough
7. Anjaparavanda P Naren
8. Shyamala Dakshinamurti
9. Prashen Chelikani

A key residue of the extracellular gate provides quality control contributing to ABCG substrate specificity

1. Jian Xia
2. Alexandra Siffert
3. Odalys Torres
4. Francesca Iacobini
5. Joanna Banasiak
6. Konrad Pakuła
7. Jörg Ziegler
8. Sabine Rosahl
9. Noel Ferro
10. Michał Jasiński
11. Tamás Hegedűs
12. Markus M. Geisler

Ligand-coupled conformational changes in a cyclic nucleotide-gated ion channel revealed by time-resolved transition metal ion FRET

1. Pierce Eggan
2. Sharona E Gordon
3. William N Zagotta

• Curated by eLife

  eLife Assessment

  This valuable study uses fluorescence lifetime imaging and steady-state and time-resolved transition metal ion FRET to characterize conformational transitions in the isolated cyclic nucleotide binding domain of a bacterial CNG channel. The data are compelling and support the authors' conclusions. The results advance the understanding of allosteric mechanisms in CNBD channels and have theoretical and practical implications for other studies of protein allostery. A limitation is that only the cytosolic fragments of the channel were studied.

Reviewed by eLife

A Futile Cycle? Tissue Homeostatic Trans-Membrane Water Co-Transport: Kinetics, Thermodynamics, Metabolic Consequences

1. Charles S. Springer
2. Martin M. Pike
3. Thomas M. Barbara

A Cell-Permeable Nanobody to Restore F508del Cystic Fibrosis Transmembrane Conductance Regulator Activity

1. Luise Franz
2. Tihomir Rubil
3. Anita Balázs
4. Marie Overtus
5. Kristin Kemnitz-Hassanin
6. Cedric Govaerts
7. Marcus A. Mall
8. Christian P.R. Hackenberger

Automated collective variable discovery for MFSD2A transporter from molecular dynamics simulations

1. Myongin Oh
2. Margarida Rosa
3. Hengyi Xie
4. George Khelashvili

Cholesterol Dependence of the Conformational Changes in Metabotropic Glutamate Receptor 1

1. Ugochi H. Isu
2. Shadi A. Badiee
3. Adithya Polasa
4. Seyed H. Tabari
5. Mortaza Derakhshani-Molayousefi
6. Mahmoud Moradi

Coupling the role of lipids to the conformational dynamics of the ABC transporter P-glycoprotein

1. Dario De Vecchis
2. Lars V. Schäfer

Effect of two activators on the gating of a K _2P channel

1. Edward Mendez-Otalvaro
2. Wojciech Kopec
3. Bert L. de Groot

Architecture and rearrangements of a sperm-specific Na+/H+ exchanger

1. Sandipan Chowdhury
2. Kamalendu Pal

MRAP2 modifies the signaling and oligomerization state of the melanocortin-4 receptor

1. Iqra Sohail
2. Suli-Anne Laurin
3. Gunnar Kleinau
4. Vidicha Chunilal
5. Andrew Morton
6. Alfonso Brenlla-Lopez
7. Zeynep Cansu Uretmen Kagiali
8. Javier A. Tello
9. Annette G. Beck-Sickinger
10. Marie-José Blouin
11. Martin J. Lohse
12. Patrick Scheerer
13. Michel Bouvier
14. Peter McCormick
15. Paolo Annibale
16. Heike Biebermann

Alternating Access of a Neurotransmitter:Sodium Symporter Bacterial Homolog Determined from AlphaFold2 Ensembles and DEER Spectroscopy

1. Alexandra C. Schwartz
2. Richard A. Stein
3. Eva Gil-Iturbe
4. Matthias Quick
5. Hassane S. Mchaourab

Exploring the influence of pore shape on conductance and permeation

1. David Seiferth
2. Philip C. Biggin

Lipid-dependent conformational dynamics of bacterial ATP-binding cassette transporter Sav1866

1. Shadi A Badiee
2. Jeevapani Hettige
3. Mahmoud Moradi

Multiresolution molecular dynamics simulations reveal the interplay between conformational variability and functional interactions in membrane-bound cytochrome 2B4

1. Sungho Bosco Han
2. Jonathan Teuffel
3. Goutam Mukherjee
4. Rebecca C. Wade

Molecular basis of proton sensing by G protein-coupled receptors

1. Matthew K. Howard
2. Nicholas Hoppe
3. Xi-Ping Huang
4. Darko Mitrovic
5. Christian B. Billesbølle
6. Christian B. Macdonald
7. Eshan Mehrotra
8. Patrick Rockefeller Grimes
9. Donovan D. Trinidad
10. Lucie Delemotte
11. Justin G. English
12. Willow Coyote-Maestas
13. Aashish Manglik

Bi-directional allosteric pathway in NMDA receptor activation and modulation

1. Paula A. Bender
2. Subhajit Chakraborty
3. Ryan J. Durham
4. Vladimir Berka
5. Elisa Carrillo
6. Vasanthi Jayaraman

Unlocking TAS2R14 activation through intricate multi-ligand binding networks

1. Xiaolong Hu
2. Weizhen Ao
3. Mingxin Gao
4. Lijie Wu
5. Yuan Pei
6. Shenhui Liu
7. Qianqian Sun
8. Junlin Liu
9. Longquan Jiang
10. Yiran Wu
11. Xin Wang
12. Yan Li
13. Qiwen Tan
14. Jie Cheng
15. Fan Yang
16. Chi Yang
17. Jinpeng Sun
18. Tian Hua
19. Zhi-Jie Liu

Structural and Dynamic Insights into the Biased Signaling Mechanism of the Human Kappa Opioid Receptor

1. Chiyo Suno-Ikeda
2. Ryo Nishikawa
3. Riko Suzuki
4. Seiya Iwata
5. Tomoyo Takai
6. Takaya Ogura
7. Mika Hirose
8. Akitoshi Inoue
9. Eri Asai
10. Ryoji Kise
11. Yukihiko Sugita
12. Takayuki Kato
13. Hiroshi Nagase
14. Tsuyoshi Saitoh
15. Kota Katayama
16. Asuka Inoue
17. Hideki Kandori
18. Takuya Kobayashi
19. Ryoji Suno

Selectivity and evolution of Aqp10 in solute permeability influenced by pore molecular weight

1. Ayumi Nagashima
2. Kazutaka Ushio
3. Hidenori Nishihara
4. Jin Akimoto
5. Akira Kato
6. Tadaomi Furuta