Reading List

Probing the substrate binding-induced conformational change of a ZIP metal transporter using a sandwich ELISA

1. Yao Zhang
2. Ryan Hu
3. Min Su
4. Jian Hu

MDPath: Unraveling Allosteric Communication Paths of Drug Targets through Molecular Dynamics Simulations

1. Niklas Piet Doering
2. Marvin Taterra
3. Marcel Bermudez
4. Gerhard Wolber

The BK channel-NS1619 agonist complex reveals molecular insights on allosteric activation gating

1. Naileth Gonzalez-Sanabria
2. Gustavo F. Contreras
3. Maximiliano Rojas
4. Yorley Duarte
5. Fernando D. Gonzalez-Nilo
6. Eduardo Perozo
7. Ramon Latorre

Molecular basis for multidrug efflux by an anaerobic RND transporter

1. Ryan Lawrence
2. Mohd Athar
3. Muhammad R. Uddin
4. Christopher Adams
5. Joana S. Sousa
6. Oliver Durrant
7. Sophie Lellman
8. Lucy Sutton
9. C. William Keevil
10. Nisha Patel
11. Christine Prosser
12. David McMillan
13. Helen I. Zgurskaya
14. Attilio V. Vargiu
15. Zainab Ahdash
16. Eamonn Reading

Computational design of constitutively active mutants of Dopamine D2 receptor inspired by ligand-independent activation mechanisms

1. Yue Chen
2. Marcus Saarinen
3. Akshay Naraine
4. Jens Carlsson
5. Per Svenningsson
6. Lucie Delemotte

Non-canonical regulation of the plasma membrane copper transporter CTR1 through modulation of membrane mechanical properties

1. Arnab Gupta
2. Bidisha Sinha
3. Durba Sengupta
4. Subhendu Kumar Chatterjee
5. Sumanta Kar
6. Siddhanta Nikte
7. Tisha Dash
8. Saptarshi Maji
9. Tanmoy Ghosh

Structural basis for selective inhibition of human GABA transporter GAT3

1. Jonas Sigurd Mortensen
2. Francesco Bavo
3. Alexander Peder Smiszek Pedersen
4. Julian Philipp Storm
5. Tillmann Pape
6. Bente Frølund
7. Petrine Wellendorph
8. Azadeh Shahsavar

Generative Landscapes and Dynamics to Design Multidomain Artificial Transmembrane Transporters

1. Fernando Montalvillo Ortega
2. Fariha Hossain
3. Vladimir V. Volobouev
4. Gabriele Meloni
5. Hedieh Torabifard
6. Faruck Morcos

Molecular dynamics of membrane partitioning of nifedipine prior to binding calcium channel Cav1.1

1. Warre Dhondt
2. Louis Vanduyfhuys
3. Ahmad Reza Mehdipour

Structural Insights into Kainate Receptor Desensitization

1. Changping Zhou
2. Guadalupe Segura-Covarrubias
3. Nami Tajima

Molecular dynamics study of differential effects of serotonin-2A-receptor (5-HT2AR) modulators

1. Jordy Peeters
2. Dimitri De Bundel
3. Kenno Vanommeslaeghe

Extracellular Nanobody Screening using Conformationally Stable GPCR

1. Xin Zhang
2. Kaixuan Gao
3. Jia Nie
4. Hengyu Meng
5. Xiaoou Sun
6. Jiawei Zhao
7. Xiangyu Liu

A GPCR-G protein-β-arrestin megacomplex induced by an allosteric modulator

1. Guodong He
2. Qinxin Sun
3. Xinyu Xu
4. Fang Kong
5. Shuhao Zhang
6. Kexin Ye
7. Xiaoou Sun
8. Xin Chen
9. Chuangye Yan
10. Xiangyu Liu

A pan-positive allosteric modulator that mediates sustainable GPCR activation

1. Qinxin Sun
2. Guodong He
3. Xinyu Xu
4. Fang Kong
5. Shuhao Zhang
6. Xiaoou Sun
7. Chuangye Yan
8. Xiangyu Liu

De novo design of miniprotein agonists and antagonists targeting G protein-coupled receptors

1. Edin Muratspahić
2. David Feldman
3. David E. Kim
4. Xiangli Qu
5. Ana-Maria Bratovianu
6. Paula Rivera-Sánchez
7. Jan Hendrik Voss
8. Emil P. T. Hertz
9. Mads Jeppesen
10. Federica Dimitri
11. Kensuke Sakamoto
12. Amrita Nallathambi
13. Pia Peceli
14. Jianjun Cao
15. Brian P. Cary
16. Matthew J. Belousoff
17. Peter Keov
18. Phuc N.H. Trinh
19. Qingchao Chen
20. Yue Ren
21. Justyn Fine
22. Sudha Mishra
23. Annu Dalal
24. Shachie Sinha
25. Ramanuj Banerjee
26. Manisankar Ganguly
27. Karthik Varappalayam Karuppusamy
28. Isaac Sappington
29. Thomas Schlichthaerle
30. Jason Z. Zhang
31. Arvind Pillai
32. Brian Coventry
33. Ljubica Mihaljević
34. Magnus Bauer
35. Susana Vázquez Torres
36. Amir Motmaen
37. Gyu Rie Lee
38. Long Tran
39. Xinru Wang
40. Inna Goreshnik
41. Dionne K. Vafeados
42. Justin E. Svendsen
43. Parisa Hosseinzadeh
44. Nicolai Lindegaard
45. Matthäus Brandt
46. Yann Waltenspühl
47. Kristine Deibler
48. Lukas Deweid
49. Anja Bennett
50. Jendrik Schöppe
51. Tiantang Dong
52. Xiaoli Yan
53. Luke Oostdyk
54. William Cao
55. Lakshmi Anantharaman
56. Johan J. Weisser
57. Jesper Frank Bastlund
58. Christoffer Bundgaard
59. Ayodeji A. Asuni
60. Justin G. English
61. Lance Stewart
62. Lauren Halloran
63. Jamie B. Spangler
64. André Lieber
65. Arun K. Shukla
66. Patrick M. Sexton
67. Bryan L. Roth
68. Brian E. Krumm
69. Denise Wootten
70. Christopher G. Tate
71. Christoffer Norn
72. David Baker

Reviewed by Arcadia Science

Structures of the honeybee GABA _A RDL receptor illuminate allosteric modulation

1. Tatiana Labouré
2. Mayank Prakash Pandey
3. Eleftherios Zarkadas
4. Céline Juillan-Binard
5. Delphine Baud
6. Jacques Neyton
7. Thierry Cens
8. Matthieu Rousset
9. François Dehez
10. Pierre Charnet
11. Hugues Nury

Identification and characterization of potent and selective inhibitors for the B ⁰ AT2/SLC6A15 amino acid transporter

1. S Cuboni
2. F Hausch

Cryo-EM structures of a pentameric ligand-gated ion channel in liposomes

1. Vikram Dalal
2. Brandon K Tan
3. Hanrui Xu
4. Wayland WL Cheng

• Curated by eLife

  eLife Assessment

  The reported cryo-EM imaging of a pentameric ligand-gated ion channel in liposomes as opposed to nanodiscs has both broad implications and contributes valuable methodological advances to the structural investigation of membrane receptors. The comparison of structures assigned to distinct functional states in liposomes versus nanodiscs is convincing and will aid membrane protein structural biologists in selection of functionally relevant membrane reconstitution environments.

Reviewed by eLife

Animal-free recombinant nanobody rescues HCN4 channel deficit in sinus node dysfunction

1. Atiyeh Sadat Sharifzadeh
2. Roberta Castelli
3. Alessandro Porro
4. Pietro Mesirca
5. Romain Perrier
6. Ana M Gómez
7. Hugo Benoit
8. Albano C. Meli
9. Luca M G Palloni
10. Dario DiFrancesco
11. Matteo E. Mangoni
12. Gerhard Thiel
13. Andrea Saponaro
14. Anna Moroni

Antidepressants interact with an LPA ₃ receptor binding site: functional and docking studies

1. K. Helivier Solís
2. Ana I. Jardón-Ibañez
3. M. Teresa Romero-Ávila
4. Ruth Rincón-Heredia
5. José Correa-Basurto
6. J. Adolfo García-Sáinz