Reading List

DeorphaNN: Virtual screening of GPCR peptide agonists using AlphaFold-predicted active-state complexes and deep learning embeddings

1. Larissa Ferguson
2. Sébastien Ouellet
3. Elke Vandewyer
4. Christopher Wang
5. Zaw Wunna
6. Tony K.Y. Lim
7. William R. Schafer
8. Isabel Beets

NEMO recruitment at single cytokine-receptor complexes shows quantized dynamics independent of ligand affinity

1. A. Hyun Kim
2. Benjamin Krummenacher
3. Jason Yeung
4. David R. Koes
5. Robin E.C. Lee

On-cell Saturation Transfer Difference (STD) NMR on ion channels: characterizing negative allosteric modulator binding interactions of P2X7

1. Serena Monaco
2. Jacob Browne
3. Matthew Wallace
4. Jesus Angulo
5. Leanne Stokes

Cryo-EM structure of a cell-free synthesized full-length human β1-adrenergic receptor in complex with Gs

1. Felipe Merino
2. Zoe Köck
3. Utz Ermel
4. Philipp Dahlhaus
5. Anna Grimm
6. Anja Seybert
7. Jan Kubicek
8. Achilleas S. Frangakis
9. Volker Dötsch
10. Daniel Hilger
11. Frank Bernhard

Antimuscarinic drugs exert β-arrestin-biased agonism at the muscarinic acetylcholine type 1 receptor

1. Shayan Amiri
2. Mohamad-Reza Aghanoori
3. Darrell R Smith
4. T.M. Zaved Waise
5. Ying Lao
6. Asuka Inoue
7. Rene Zahedi
8. Henry A Dunn
9. Paul Fernyhough

P-Rex1 Limits the Agonist-Induced Internalisation of GPCRs Independently of its Rac-GEF Activity

1. Martin J. Baker
2. Elizabeth Hampson
3. Priota Islam
4. Ruben Pelaez Moral
5. Eve A. Maunders
6. Kirsti Hornigold
7. Elpida Tsonou
8. David C. Hornigold
9. Roderick E. Hubbard
10. Andrew J. Massey
11. Heidi C. E. Welch

Three-row stereocilia model predicts mammalian hair bundle behavior

1. Varun Goyal
2. Karl Grosh

From transporter to motor: Evolutionary and structural insights into the emergence of prestin's area‐motor activity in mammals

1. Nicolás Fuentes‐Ugarte
2. Tiaren Ruiz‐Rojas
3. Felipe Garcia‐Olave
4. Alvaro Ruiz‐Fernandez
5. Jose Antonio Garate
6. Victor Castro‐Fernandez
7. Raul Araya‐Secchi

Allosteric modulation of dimeric GPR3 by ligands in the dimerization interface

1. Zeming Qiu
2. Wei Wang
3. Yingying Nie
4. Junxiang Lin
5. Beimeng Zhang
6. Haonan Xing
7. Sanduo Zheng

• Curated by eLife

  eLife Assessment

  Qiu et al. present multiple dimeric structures of GPR3, which reveal the binding mode of the inverse agonist AF64394. The findings provide important insights into the regulation of GPCR3 and potentially other related orphan GPCRs. The authors present convincing evidence of their claims through thoughtful analysis of their cryo-EM structures, mutagenesis, and cell-based assays. This work will be of interest to GPCR investigators, especially those studying the signaling of orphan receptors.

Reviewed by eLife

Serine activates defense mechanisms via glutamate receptor-like channel 3.4 and calcium-dependent protein kinase 5 signaling in plants

1. Kyounghee Lee
2. Amanda Navodani
3. Janint Camacho
4. Heejin Yoo

Structural basis of apoptosis induction by the mitochondrial voltage-dependent anion channel

1. Melina Daniilidis
2. Umut Günsel
3. Georgios Broutzakis
4. Kira D. Leitl
5. Robert Janowski
6. Kai Fredriksson
7. Dierk Niessing
8. Christos Gatsogiannis
9. Franz Hagn

β-Arrestin Condensates Regulate G Protein-Coupled Receptor Function

1. Preston J. Anderson
2. Peng Xiao
3. Yani Zhong
4. Adam Kaakati
5. Juliana Alfonso-DeSouza
6. Tianyao Zhang
7. Chao Zhang
8. Kevin Yu
9. Lei Qi
10. Wei Ding
11. Samuel Liu
12. Biswaranjan Pani
13. Athmika Krishnan
14. Oscar Chen
15. Chanpreet Jassal
16. Joseph Strawn
17. Jin-Peng Sun
18. Sudarshan Rajagopal

GLUT4 translocation with insulin: revisiting the case for dose-dependent quantal release

1. Irina Romenskaia
2. Cynthia Corley Mastick
3. Adelle C.F. Coster

Lipid-Mediated Modulation of mGluR2 Embedded in Micelle and Bilayer Environments: Insights from Molecular Dynamics

1. Ehsaneh Khodadadi
2. Shadi A badiee
3. Ehsan Khodadadi
4. Mahmoud Moradi

Energetic and structural control of polyspecificity in a multidrug transporter

1. Silas T. Miller
2. Katherine A. Henzler-Wildman
3. Srivatsan Raman

Reviewed by PREreview

Revealing molecular determinants of ligand efficacy and affinity at the D ₂ dopamine receptor through molecular dynamics simulations

1. Yue Chen
2. Nour Aldin Kahlous
3. Marcus Saarinen
4. Sergio Perez Conesa
5. Per Svenningsson
6. Lucie Delemotte
7. Jens Carlsson

FAST RESENSITIZATION OF G PROTEIN-COUPLED RECEPTORS REQUIRES THEIR PI(4,5)P ₂ -DEPENDENT SORTING INTO AN AP2 POSITIVE COMPARTMENT

1. Gergo Gulyas
2. Takashi Baba
3. Daniel J. Toth
4. Asuka Inoue
5. Tamas Balla