Evaluated articles

The psychosis risk factor RBM12 encodes a novel repressor of GPCR/cAMP signal transduction

1. Khairunnisa M. Semesta
2. Angelica Garces
3. Nikoleta G. Tsvetanova

Reviewed by Life Science Editors Foundation, Review Commons

Metabolic regulation of misfolded protein import into mitochondria

1. Yuhao Wang
2. Linhao Ruan
3. Jin Zhu
4. Xi Zhang
5. Alexander Chih-Chieh Chang
6. Alexis Tomaszewski
7. Rong Li

• Curated by eLife

  eLife assessment

  This study makes an important connection between cellular metabolism and proteostasis through MAGIC, a previously proposed protein quality control pathway of clearance of cytosolic misfolded and aggregated proteins by importing into mitochondria. The authors reveal the role of Snf1, a yeast AMPK, in preventing the import of misfolded proteins to mitochondria for MAGIC controlled by the transcription factor Hap4, depending on the cellular metabolic status. The key message is important, although the evidence for physiological relevance of MAGIC for overall cellular proteostasis and its molecular regulation by Snf1 remains incomplete.

Reviewed by eLife, Life Science Editors Foundation

Subcytoplasmic location of translation controls protein output

1. Ellen L. Horste
2. Mervin M. Fansler
3. Ting Cai
4. Xiuzhen Chen
5. Sibylle Mitschka
6. Gang Zhen
7. Flora C. Y. Lee
8. Jernej Ule
9. Christine Mayr

Reviewed by Life Science Editors Foundation