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  1. Mapping the niche of breast cancer metastases in lung and liver

    This article has 19 authors:
    1. Magdalena K. Sznurkowska
    2. Francesc Castro-Giner
    3. Yongzhan Zhang
    4. Alexander Ring
    5. Fabienne Dominique Schwab
    6. Francesca Albrecht
    7. Kirsten D. Mertz
    8. Karin Strittmatter
    9. Lauren L. Ozimski
    10. Selina Budinjas
    11. Gaël Auray
    12. Claudio Giachino
    13. Verdon Taylor
    14. Ana Gvozdenovic
    15. Ilaria Malanchi
    16. Heike Frauchiger-Heuer
    17. Andreas Wicki
    18. Marcus Vetter
    19. Nicola Aceto

    Reviewed by Life Science Editors Foundation

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  2. Metabolic regulation of misfolded protein import into mitochondria

    This article has 7 authors:
    1. Yuhao Wang
    2. Linhao Ruan
    3. Jin Zhu
    4. Xi Zhang
    5. Alexander Chih-Chieh Chang
    6. Alexis Tomaszewski
    7. Rong Li
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study makes a connection between cellular metabolism and proteostasis through MAGIC, a previously proposed protein quality control pathway of clearance of cytosolic misfolded and aggregated proteins by importing into mitochondria. The authors reveal the role of Snf1, a yeast AMPK, in preventing the import of misfolded proteins to mitochondria for MAGIC controlled by the transcription factor Hap4, depending on the cellular metabolic status. The key message is important, although the evidence for physiological relevance of MAGIC for overall cellular proteostasis and its molecular regulation by Snf1 remains incomplete.

    Reviewed by eLife, Life Science Editors Foundation

    This article has 8 evaluationsAppears in 3 listsLatest version Latest activity