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  1. Drug targeting Nsp1-ribosomal complex shows antiviral activity against SARS-CoV-2

    This article has 7 authors:
    1. Mohammad Afsar
    2. Rohan Narayan
    3. Md Noor Akhtar
    4. Huma Rahil
    5. Sandeep M Eswarappa
    6. Shashank Tripathi
    7. Tanweer Hussain
    This article has been curated by 1 group:
    • Curated by eLife

      Evaluation Summary:

      This work reports on a drug repurposing effort to target the non-structural protein 1 (Nsp1) of SARS-Cov-2, involved in suppressing host immune function. The authors use a combination of computational, in vitro and cellular assays to this end. They start by virtual screening of an FDA approved drug library, followed by biophysical assays to measure the binding affinity of the top hits as well as molecular dynamics simulations and free energy calculations to confirm binding poses. Finally, in vitro and cellular assays were used to quantify translation inhibition and rescue as well as the production of infectious virus particles. One of the FDA approved drugs, Montelukast, emerges as a promising antiviral drug candidate.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

    Reviewed by eLife, ScreenIT

    This article has 5 evaluationsAppears in 4 listsLatest version Latest activity
  2. SARS-CoV-2 ORF8 encoded protein contains a histone mimic, disrupts chromatin regulation, and enhances replication

    This article has 22 authors:
    1. John Kee
    2. Samuel Thudium
    3. David Renner
    4. Karl Glastad
    5. Katherine Palozola
    6. Zhen Zhang
    7. Yize Li
    8. Joseph Cesare
    9. Yemin Lan
    10. Rachel Truitt
    11. Fabian L. Cardenas-Diaz
    12. Darrell N. Kotton
    13. Konstantinos D. Alysandratos
    14. Xianwen Zhang
    15. Xuping Xie
    16. Pei-Yong Shi
    17. Wenli Yang
    18. Edward Morrisey
    19. Benjamin A. Garcia
    20. Shelley L. Berger
    21. Susan R. Weiss
    22. Erica Korb

    Reviewed by ScreenIT

    This article has 1 evaluationAppears in 2 listsLatest version Latest activity
  3. Metformin Suppresses SARS-CoV-2 in Cell Culture

    This article has 4 authors:
    1. Haripriya Parthasarathy
    2. Dixit Tandel
    3. Abdul Hamid Siddiqui
    4. Krishnan H. Harshan

    Reviewed by ScreenIT

    This article has 1 evaluationAppears in 2 listsLatest version Latest activity
  4. Atazanavir is a competitive inhibitor of SARS-CoV-2 M pro , impairing variants replication in vitro and in vivo

    This article has 18 authors:
    1. Otávio Augusto Chaves
    2. Carolina Q. Sacramento
    3. André C. Ferreira
    4. Mayara Mattos
    5. Natalia Fintelman-Rodrigues
    6. Jairo R. Temerozo
    7. Douglas Pereira Pinto
    8. Gabriel P. E. da Silveira
    9. Laís Bastos da Fonseca
    10. Heliana Martins Pereira
    11. Aluana Santana Carlos
    12. Joana da Costa Pinto d’Ávila
    13. João P.B. Viola
    14. Robson Q. Monteiro
    15. Leonardo Vazquez
    16. Patrícia T. Bozza
    17. Hugo Caire Castro-Faria-Neto
    18. Thiago Moreno L. Souza

    Reviewed by ScreenIT

    This article has 1 evaluationAppears in 2 listsLatest version Latest activity