@FinMcS's saved articles

Mitoxantrone modulates a glycosaminoglycan-spike complex to inhibit SARS-CoV-2 infection

1. Qi Zhang
2. Peter Radvak
3. Juhyung Lee
4. Yue Xu
5. Vivian Cao-Dao
6. Miao Xu
7. Wei Zheng
8. Catherine Z. Chen
9. Hang Xie
10. Yihong Ye

Reviewed by ScreenIT

Discovery of Triple Inhibitors of Both SARS-CoV-2 Proteases and Human Cathepsin L

1. Ittipat Meewan
2. Jacob Kattoula
3. Julius Y. Kattoula
4. Danielle Skinner
5. Pavla Fajtová
6. Miriam A. Giardini
7. Brendon Woodworth
8. James H. McKerrow
9. Jair Lage de Siqueira-Neto
10. Anthony J. O’Donoghue
11. Ruben Abagyan

Reviewed by ScreenIT

Drug targeting Nsp1-ribosomal complex shows antiviral activity against SARS-CoV-2

1. Mohammad Afsar
2. Rohan Narayan
3. Md Noor Akhtar
4. Deepakash Das
5. Huma Rahil
6. Santhosh Kambaiah Nagaraj
7. Sandeep M Eswarappa
8. Shashank Tripathi
9. Tanweer Hussain

• Curated by eLife

  Evaluation Summary:

  This work reports on a drug repurposing effort to target the non-structural protein 1 (Nsp1) of SARS-Cov-2, involved in suppressing host immune function. The authors use a combination of computational, in vitro and cellular assays to this end. They start by virtual screening of an FDA approved drug library, followed by biophysical assays to measure the binding affinity of the top hits as well as molecular dynamics simulations and free energy calculations to confirm binding poses. Finally, in vitro and cellular assays were used to quantify translation inhibition and rescue as well as the production of infectious virus particles. One of the FDA approved drugs, Montelukast, emerges as a promising antiviral drug candidate.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

Reviewed by eLife, ScreenIT

SARS-CoV-2 ORF8 encoded protein contains a histone mimic, disrupts chromatin regulation, and enhances replication

1. John Kee
2. Samuel Thudium
3. David Renner
4. Karl Glastad
5. Katherine Palozola
6. Zhen Zhang
7. Yize Li
8. Joseph Cesare
9. Yemin Lan
10. Rachel Truitt
11. Fabian L. Cardenas-Diaz
12. Darrell N. Kotton
13. Konstantinos D. Alysandratos
14. Xianwen Zhang
15. Xuping Xie
16. Pei-Yong Shi
17. Wenli Yang
18. Edward Morrisey
19. Benjamin A. Garcia
20. Shelley L. Berger
21. Susan R. Weiss
22. Erica Korb

Reviewed by ScreenIT

Reduced replication but increased interferon resistance of SARS-CoV-2 Omicron BA.1

1. Rayhane Nchioua
2. Annika Schundner
3. Susanne Klute
4. Lennart Koepke
5. Maximilian Hirschenberger
6. Sabrina Noettger
7. Giorgio Fois
8. Fabian Zech
9. Alexander Graf
10. Stefan Krebs
11. Peter Braubach
12. Helmut Blum
13. Steffen Stenger
14. Dorota Kmiec
15. Manfred Frick
16. Frank Kirchhoff
17. Konstantin MJ Sparrer

Reviewed by ScreenIT

Metformin suppresses SARS-CoV-2 in cell culture

1. Haripriya Parthasarathy
2. Dixit Tandel
3. Abdul Hamid Siddiqui
4. Krishnan H. Harshan

Reviewed by ScreenIT

Atazanavir Is a Competitive Inhibitor of SARS-CoV-2 Mpro, Impairing Variants Replication In Vitro and In Vivo

1. Otávio Augusto Chaves
2. Carolina Q. Sacramento
3. André C. Ferreira
4. Mayara Mattos
5. Natalia Fintelman-Rodrigues
6. Jairo R. Temerozo
7. Leonardo Vazquez
8. Douglas Pereira Pinto
9. Gabriel P. E. da Silveira
10. Laís Bastos da Fonseca
11. Heliana Martins Pereira
12. Aluana Santana Carlos
13. Joana C. d’Avila
14. João P. B. Viola
15. Robson Q. Monteiro
16. Patrícia T. Bozza
17. Hugo Caire Castro-Faria-Neto
18. Thiago Moreno L. Souza

Reviewed by ScreenIT