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Latest preprint reviews

1. Clinically observed deletions in SARS‐CoV‐2 Nsp1 affect its stability and ability to inhibit translation

   This article has 7 authors:

   1. Pravin Kumar
   2. Erin Schexnaydre
   3. Karim Rafie
   4. Tatsuaki Kurata
   5. Ilya Terenin
   6. Vasili Hauryliuk
   7. Lars‐Anders Carlson

   Reviewed by ScreenIT

2. Protein Arginylation Is Regulated during SARS-CoV-2 Infection

   This article has 15 authors:

   1. Janaina Macedo-da-Silva
   2. Livia Rosa-Fernandes
   3. Vinicius de Morais Gomes
   4. Veronica Feijoli Santiago
   5. Deivid Martins Santos
   6. Catarina Maria Stanischesk Molnar
   7. Bruno Rafael Barboza
   8. Edmarcia Elisa de Souza
   9. Rodolfo Ferreira Marques
   10. Silvia Beatriz Boscardin
   11. Edison Luiz Durigon
   12. Claudio Romero Farias Marinho
   13. Carsten Wrenger
   14. Suely Kazue Nagahashi Marie
   15. Giuseppe Palmisano

   Reviewed by Rapid Reviews Infectious Diseases, ScreenIT

3. Drug targeting Nsp1-ribosomal complex shows antiviral activity against SARS-CoV-2

   This article has 9 authors:

   1. Mohammad Afsar
   2. Rohan Narayan
   3. Md Noor Akhtar
   4. Deepakash Das
   5. Huma Rahil
   6. Santhosh Kambaiah Nagaraj
   7. Sandeep M Eswarappa
   8. Shashank Tripathi
   9. Tanweer Hussain

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This work reports on a drug repurposing effort to target the non-structural protein 1 (Nsp1) of SARS-Cov-2, involved in suppressing host immune function. The authors use a combination of computational, in vitro and cellular assays to this end. They start by virtual screening of an FDA approved drug library, followed by biophysical assays to measure the binding affinity of the top hits as well as molecular dynamics simulations and free energy calculations to confirm binding poses. Finally, in vitro and cellular assays were used to quantify translation inhibition and rescue as well as the production of infectious virus particles. One of the FDA approved drugs, Montelukast, emerges as a promising antiviral drug candidate.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife, ScreenIT

4. Glycan Masking of Epitopes in the NTD and RBD of the Spike Protein Elicits Broadly Neutralizing Antibodies Against SARS-CoV-2 Variants

   This article has 5 authors:

   1. Wei-Shuo Lin
   2. I-Chen Chen
   3. Hui-Chen Chen
   4. Yi-Chien Lee
   5. Suh-Chin Wu

   Reviewed by ScreenIT

5. Effectiveness evaluation of digital contact tracing for COVID-19 in New South Wales, Australia

   This article has 5 authors:

   1. Florian Vogt
   2. Bridget Haire
   3. Linda Selvey
   4. Anthea L Katelaris
   5. John Kaldor

   Reviewed by ScreenIT

6. Viral E protein neutralizes BET protein-mediated post-entry antagonism of SARS-CoV-2

   This article has 22 authors:

   1. Irene P. Chen
   2. James E. Longbotham
   3. Sarah McMahon
   4. Rahul K. Suryawanshi
   5. Mir M. Khalid
   6. Taha Y. Taha
   7. Takako Tabata
   8. Jennifer M. Hayashi
   9. Frank W. Soveg
   10. Jared Carlson-Stevermer
   11. Meghna Gupta
   12. Meng Yao Zhang
   13. Victor L. Lam
   14. Yang Li
   15. Zanlin Yu
   16. Erron W. Titus
   17. Amy Diallo
   18. Jennifer Oki
   19. Kevin Holden
   20. Nevan Krogan
   21. Danica Galonić Fujimori
   22. Melanie Ott

   Reviewed by ScreenIT

7. The oral protease inhibitor (PF-07321332) protects Syrian hamsters against infection with SARS-CoV-2 variants of concern

   This article has 17 authors:

   1. Rana Abdelnabi
   2. Caroline S. Foo
   3. Dirk Jochmans
   4. Laura Vangeel
   5. Steven De Jonghe
   6. Patrick Augustijns
   7. Raf Mols
   8. Birgit Weynand
   9. Thanaporn Wattanakul
   10. Richard M. Hoglund
   11. Joel Tarning
   12. Charles E. Mowbray
   13. Peter Sjö
   14. Fanny Escudié
   15. Ivan Scandale
   16. Eric Chatelain
   17. Johan Neyts

   Reviewed by ScreenIT

8. Serum from COVID-19 patients early in the pandemic shows limited evidence of cross-neutralization against variants of concern

   This article has 8 authors:

   1. Amanda J. Griffin
   2. Kyle L. O’Donnell
   3. Kyle Shifflett
   4. John-Paul Lavik
   5. Patrick M. Russell
   6. Michelle K. Zimmerman
   7. Ryan F. Relich
   8. Andrea Marzi

   Reviewed by ScreenIT

9. Stable Cell Clones Harboring Self-Replicating SARS-CoV-2 RNAs for Drug Screen

   This article has 5 authors:

   1. Shufeng Liu
   2. Chao-Kai Chou
   3. Wells W. Wu
   4. Binquan Luan
   5. Tony T. Wang

   Reviewed by ScreenIT

10. Monitoring of SARS-CoV-2 antibodies using dried blood spot for at-home collection

    This article has 3 authors:

    1. Peyton K. Miesse
    2. Bradley B. Collier
    3. Russell P. Grant

    Reviewed by ScreenIT