Review Commons

Latest preprint reviews

1. In vivo mapping of protein-protein interactions of schizophrenia risk factors generates an interconnected disease network

   This article has 3 authors:

   1. Daniel B. McClatchy
   2. Susan B. Powell
   3. John R. Yates

   Reviewed by Review Commons

2. DNA replication in primary hepatocytes without the six-subunit ORC

   This article has 12 authors:

   1. Róża K Przanowska
   2. Yuechuan Chen
   3. Takayuki-Okano Uchida
   4. Etsuko Shibata
   5. Xiaoxiao Hao
   6. Isaac Segura Rueda
   7. Kate Jensen
   8. Piotr Przanowski
   9. Anthony Trimboli
   10. Yoshiyuki Shibata
   11. Gustavo Leone
   12. Anindya Dutta

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable descriptive manuscript builds on prior research showing that the elimination of Origin Recognition Complex (ORC) subunits does not halt DNA replication. The authors obtain solid data using various methods to genetically remove one or two ORC subunits from specific tissues and still observe replication. The replication appears to be primarily endoreduplication, indicating that ORC-independent replication may promote genome reduplication without mitosis. The mechanism behind this ORC-independent replication remains to be elucidated. The study and mutants described herein lay the groundwork for future research to explore how cells compensate for the absence of ORC and to develop functional approaches to investigate this process. The reviewers suggested the observations could be supported by additional experiments. This work will be of interest to those studying genome duplication and replication.

   Reviewed by eLife, Review Commons

3. Capturing cell heterogeneity in representations of cell populations for image-based profiling using contrastive learning

   This article has 5 authors:

   1. Robert van Dijk
   2. John Arevalo
   3. Mehrtash Babadi
   4. Anne E. Carpenter
   5. Shantanu Singh

   Reviewed by Review Commons

4. Toll-1-dependent immune evasion induced by fungal infection leads to cell loss in the Drosophila brain

   This article has 9 authors:

   1. Deepanshu N. D. Singh
   2. Abigail R. E. Roberts
   3. Xiaocui Wang
   4. Guiyi Li
   5. Enrique Quesada Moraga
   6. David Alliband
   7. Elizabeth Ballou
   8. Hung-Ji Tsai
   9. Alicia Hidalgo

   Reviewed by Review Commons

5. A Lgr5-independent developmental lineage is involved in mouse intestinal regeneration

   This article has 11 authors:

   1. Maryam Marefati
   2. Valeria Fernandez-Vallone
   3. Morgane Leprovots
   4. Gabriella Vasile
   5. Frédérick Libert
   6. Anne Lefort
   7. Gilles Dinsart
   8. Achim Weber
   9. Jasna Jetzer
   10. Marie-Isabelle Garcia
   11. Gilbert Vassart

   Reviewed by Review Commons

6. Mechanisms of cilia regeneration in Xenopus multiciliated epithelium in vivo

   This article has 5 authors:

   1. Venkatramanan G. Rao
   2. Vignesharavind Subramanianbalachandar
   3. Magdalena M. Magaj
   4. Stefanie Redemann
   5. Saurabh S. Kulkarni

   Reviewed by Review Commons, Arcadia Science

7. An intestinal Sir2-HSF1-ATGL1 pathway regulates lipolysis in C. elegans

   This article has 6 authors:

   1. Milán Somogyvári
   2. Saba Khatatneh
   3. Gábor Hajdú
   4. Bar Sotil
   5. József Murányi
   6. Csaba Sőti

   Reviewed by Review Commons

8. Ca ²⁺ binding to Esyt is required to modulate membrane contact site density in Drosophila photoreceptors

   This article has 4 authors:

   1. Vaisaly R Nath
   2. Harini Krishnan
   3. Shirish Mishra
   4. Padinjat Raghu

   Reviewed by Review Commons

9. Interferon-Induced PARP14-Mediated ADP-Ribosylation in p62 Bodies Requires an Active Ubiquitin-Proteasome System

   This article has 7 authors:

   1. Rameez Raja
   2. Banhi Biswas
   3. Rachy Abraham
   4. Hongrui Liu
   5. Che-Yuan Chang
   6. Hien Vu
   7. Anthony K. L. Leung

   Reviewed by PREreview, Review Commons

10. Bellymount-pulsed tracking: a novel approach for real-time in vivo imaging of Drosophila abdominal tissues

    This article has 2 authors:

    1. Shruthi Balachandra
    2. Amanda A Amodeo

    Reviewed by Review Commons