Review Commons

Latest preprint reviews

1. Dynamic multi-omics and mechanistic modeling approach uncovers novel mechanisms of kidney fibrosis progression

   This article has 14 authors:

   1. Nadine Tuechler
   2. Mira Lea Burtscher
   3. Martin Garrido-Rodriguez
   4. Muzamil Majid Khan
   5. Dénes Türei
   6. Christian Tischer
   7. Sarah Kaspar
   8. Jennifer Jasmin Schwarz
   9. Frank Stein
   10. Mandy Rettel
   11. Rafael Kramann
   12. Mikhail M Savitski
   13. Julio Saez-Rodriguez
   14. Rainer Pepperkok

   Reviewed by Review Commons

2. Proximity Interactome analyses unveil novel regulators of IRE1α canonical signaling

   This article has 16 authors:

   1. Simon Le Goupil
   2. Céline Philippe
   3. Hadrien Laprade
   4. Mathéo Lode
   5. Rachel Boniface
   6. Diana Pelizzari-Raymundo
   7. Kurt Dejgaard
   8. Gregor Jansen
   9. Celia Limia
   10. Claudio Hetz
   11. S. Jalil Mahdizadeh
   12. Luc Negroni
   13. Marc Aubry
   14. Jean-Ehrland Ricci
   15. Leif A. Eriksson
   16. Eric Chevet

   Reviewed by Review Commons

3. An unconventional interaction interface between the peroxisomal targeting factor Pex5 and Eci1 enables PTS1 independent import

   This article has 9 authors:

   1. Lior Peer
   2. Nadav Elad
   3. Orly Dym
   4. Asa Tirosh
   5. Jossef Jacobovitch
   6. Shira Albeck
   7. Maya Schuldiner
   8. Yoav Peleg
   9. Einat Zalckvar

   Reviewed by Review Commons

4. Tension-induced suppression of allosteric conformational changes explains coordinated stepping of kinesin-1

   This article has 10 authors:

   1. Tsukasa Makino
   2. Ryo Kanada
   3. Teppei Mori
   4. Ken-ichi Miyazono
   5. Yuta Komori
   6. Haruaki Yanagisawa
   7. Shoji Takada
   8. Masaru Tanokura
   9. Masahide Kikkawa
   10. Michio Tomishige

   Reviewed by Review Commons

5. Kinetic regulation of kinesin’s two motor domains coordinates its stepping along microtubules

   This article has 5 authors:

   1. Yamato Niitani
   2. Kohei Matsuzaki
   3. Erik Jonsson
   4. Ronald D Vale
   5. Michio Tomishige

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides compelling evidence that kinesin's stepping mechanism is governed by strain-induced conformational changes in its nucleotide-binding pockets. Using pre-steady state kinetics and single-molecule assays, the authors demonstrate that the neck linker's conformation differentially modulates nucleotide affinity and detachment rates, establishing an asynchronous chemo-mechanical cycle that prevents simultaneous detachment. Supported by cryo-EM structural data, the work presents an important advance in our understanding of kinesin's hand-over-hand movement.

     [Editors' note: this paper was reviewed by Review Commons.]

   Reviewed by eLife, Review Commons

6. Hydroxyurea induces ER stress and cytoplasmic protein aggregation

   This article has 8 authors:

   1. Ana Sánchez-Molina
   2. Manuel Bernal
   3. Joel D. Posligua-García
   4. Antonio J. Pérez-Pulido
   5. Laura de Cubas
   6. Elena Hidalgo
   7. Silvia Salas-Pino
   8. Rafael R. Daga

   Reviewed by Review Commons

7. Whole genome CRISPR screens identify a LRRK2-regulated pathway for extracellular tau uptake by human neurons

   This article has 14 authors:

   1. Lewis D. Evans
   2. Alessio Strano
   3. Eleanor Tuck
   4. Ashley Campbell
   5. James Smith
   6. Christy Hung
   7. Tiana S. Behr
   8. Bernardino Ghetti
   9. Benjamin Ryskeldi-Falcon
   10. Emre Karakoc
   11. Francesco Iorio
   12. Alastair Reith
   13. Andrew R. Bassett
   14. Frederick J. Livesey

   Reviewed by Review Commons

8. Early coordination of cell migration and cardiac fate determination during mammalian gastrulation

   This article has 8 authors:

   1. Shayma Abukar
   2. Peter A Embacher
   3. Alessandro Ciccarelli
   4. Sunita Varsani-Brown
   5. Isabel G W North
   6. Jamie A Dean
   7. James Briscoe
   8. Kenzo Ivanovitch

   Reviewed by Review Commons

9. Non-muscle myosin II regulates presynaptic actin assemblies and neuronal mechanobiology in Drosophila

   This article has 3 authors:

   1. Biljana Ermanoska
   2. Jonathan Baets
   3. Avital A. Rodal

   Reviewed by Review Commons

10. GLE1 dysfunction compromises cellular homeostasis, spatial organization, and peripheral axon branching

    This article has 17 authors:

    1. T Zárybnický
    2. S Lindfors
    3. S Metso
    4. Z Szabo
    5. R Valtonen
    6. M Tulppo
    7. J Magga
    8. S Saarimäki
    9. S Bläuer
    10. I Miinalainen
    11. R Kerkelä
    12. J Väänänen
    13. R Kivelä
    14. FP Zhang
    15. P Sipilä
    16. R Hinttala
    17. S Kuure

    Reviewed by Review Commons