Review Commons

Latest preprint reviews

1. Regional heterogeneities of oligodendrocytes underlie biased Ranvier node spacing along single axons in sound localization circuit

   This article has 5 authors:

   1. Ryo Egawa
   2. Kota Hiraga
   3. Ryosuke Matsui
   4. Dai Watanabe
   5. Hiroshi Kuba

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study uses the delay line axon model in the chick brainstem auditory circuit to examine the interactions between oligodendrocytes and axons in the formation of internodal distances. This is a significant and actively studied topic, and the authors have used this preparation to support the hypothesis that regional heterogeneity in oligodendrocytes underlies the observed variation in internodal length. In a solid series of experiments, the authors have used enhanced tetanus neurotoxin light chains, a genetically encoded silencing tool, to inhibit vesicular release from axons and support the hypothesis that regional heterogeneity among oligodendrocytes may underlie the biased nodal spacing pattern in the sound localization circuit.

     [Editors' note: this paper was reviewed by Review Commons.]

   Reviewed by eLife, Review Commons

2. Quantification of Cyclin-CDK dissociation constants in living cells using fluorescence cross-correlation spectroscopy with green and near-infrared fluorescent proteins

   This article has 7 authors:

   1. Aika Toyama
   2. Yuhei Goto
   3. Yuhei Yamauchi
   4. Hironori Sugiyama
   5. Yohei Kondo
   6. Atsushi Mochizuki
   7. Kazuhiro Aoki

   Reviewed by Review Commons

3. A transcription factor toggle switch determines differentiated epidermal cell identities in Hydra

   This article has 6 authors:

   1. Jaroslav Ferenc
   2. Marylène Bonvin
   3. Panagiotis Papasaikas
   4. Jacqueline Ferralli
   5. Clara Nuninger
   6. Charisios D. Tsiairis

   Reviewed by Review Commons

4. The SUMO activating enzyme subunit, SAE2, contributes SUMO protein bias for mitotic fidelity

   This article has 8 authors:

   1. Alexandra K. Walker
   2. Alexander J. Lanz
   3. Mohammed Jamshad
   4. Alexander J. Garvin
   5. Peter Wotherspoon
   6. Benjamin F. Cooper
   7. Timothy J. Knowles
   8. Joanna R. Morris

   Reviewed by Review Commons

5. Embryological cellular origins and hypoxia-mediated mechanisms in PIK3CA -Driven refractory vascular malformations

   This article has 13 authors:

   1. Sota Torii
   2. Keiki Nagaharu
   3. Nanako Nakanishi
   4. Hidehito Usui
   5. Yumiko Hori
   6. Katsutoshi Hirose
   7. Satoru Toyosawa
   8. Eiichi Morii
   9. Mitsunaga Narushima
   10. Yoshiaki Kubota
   11. Osamu Nakagawa
   12. Kyoko Imanaka-Yoshida
   13. Kazuaki Maruyama

   Reviewed by Review Commons

6. SOX2 and NR2F1 coordinate the gene expression program of the early postnatal visual thalamus

   This article has 14 authors:

   1. Linda Serra
   2. Anna Nordin
   3. Mattias Jonasson
   4. Carolina Marenco
   5. Guido Rovelli
   6. Annika Diebels
   7. Francesca Gullo
   8. Sergio Ottolenghi
   9. Federico Zambelli
   10. Michèle Studer
   11. Giulio Pavesi
   12. Claudio Cantù
   13. Silvia K. Nicolis
   14. Sara Mercurio

   Reviewed by Review Commons

7. Ribosomal RNA synthesis by RNA polymerase I is subject to premature termination of transcription

   This article has 12 authors:

   1. Chaïma Azouzi
   2. Katrin Schwank
   3. Sophie Queille
   4. Marta Kwapisz
   5. Marion Aguirrebengoa
   6. Anthony Henras
   7. Simon Lebaron
   8. Herbert Tschochner
   9. Annick Lesne
   10. Frédéric Beckouët
   11. Olivier Gadal
   12. Christophe Dez

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript characterizes a mutated clone of RNA polymerase I in yeast, referred to as SuperPol, to understand the mechanisms of RNA polymerase I elongation and termination. The authors present convincing evidence that demonstrates the existence of premature termination in Pol I transcription. Overall, the characterization of this RNA pol I offers important insights into the regulation of ribosomal RNA transcription and its potential application in cancer pharmacology.

     [Editors' note: this paper was reviewed by Review Commons.]

   Reviewed by eLife, Review Commons

8. Modularity of the segmentation clock and morphogenesis

   This article has 3 authors:

   1. James E Hammond
   2. Ruth E Baker
   3. Berta Verd

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable manuscript uses mathematical modeling to address the synchrony of the vertebrate segmentation clock with the developmental processes. The authors use convincing arguments to support the idea that this would allow the evolution of flexible body plans and a variable number of segments. This manuscript could be of interest to developmental biologists and systems biologists.

     [Editors' note: this paper was reviewed by Review Commons.]

   Reviewed by eLife, Review Commons

9. Hormone circuit explains why most HPA drugs fail for mood disorders and predicts the few that work

   This article has 6 authors:

   1. Tomer Milo
   2. Shiraz Nir Halber
   3. Moriya Raz
   4. Dor Danan
   5. Avi Mayo
   6. Uri Alon

   Reviewed by Review Commons

10. Epigenetic liquid biopsies reveal elevated vascular endothelial cell turnover and erythropoiesis in asymptomatic COVID-19 patients

    This article has 27 authors:

    1. Roni Ben-Ami
    2. Netanel Loyfer
    3. Eden Cohen
    4. Gavriel Fialkoff
    5. Israa Sharkia
    6. Naama Bogot
    7. Danit Kochan
    8. George Kalak
    9. Amir Jarjoui
    10. Chen Chen-Shuali
    11. Hava Azulai
    12. Hezi Barhoum
    13. Nissim Arish
    14. Moshe M Greenberger
    15. David Vellema
    16. Ramzi Kurd
    17. Eli Ben Chetrit
    18. Davina Bohm
    19. Talya Wolak
    20. Ahmad Quteineh
    21. Gordon Cann
    22. Benjamin Glaser
    23. Nir Friedman
    24. Tommy Kaplan
    25. Ruth Shemer
    26. Ariel Rokach
    27. Yuval Dor

    Reviewed by Review Commons, Rapid Reviews Infectious Diseases