preLights

Latest preprint reviews

1. Dectin-1 limits central nervous system autoimmunity through a non-canonical pathway

   This article has 9 authors:

   1. M. Elizabeth Deerhake
   2. Keiko Danzaki
   3. Makoto Inoue
   4. Emre D. Cardakli
   5. Toshiaki Nonaka
   6. Nupur Aggarwal
   7. William E. Barclay
   8. Ru Rong Ji
   9. Mari L. Shinohara

   Reviewed by preLights

2. STING mediates immune responses in the closest living relatives of animals

   This article has 6 authors:

   1. Arielle Woznica
   2. Ashwani Kumar
   3. Carolyn R Sturge
   4. Chao Xing
   5. Nicole King
   6. Julie K Pfeiffer

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     The authors addressed the role of a STING ortholog in antimicrobial defense of choanoflagellates. The analysis of the response of the choanoflagellate Monosiga brevicollis to a variety of bacterial species revealed that exposure of M. brevicollis to Pseudomonas aeruginosa conditioned medium results in choanoflagellate death and the authors found that this is dependent on the newly discovered ortholog of STING. Characterization reveals that the STING response can be induced by 2'3' cGAMP, which parallels the activation of STING in diverse species. In addition, the finding that cyclic dinucleotide treatment induces autophagy also has parallels with the effector pathways observed in other organisms. There are a number of strengths as outlined by the Reviewers. First, the development of a Choanaoflagellate model system to study innate immunity, second with the development of genetics for M. brevicollis, third, the demonstration of a functional STING system in one of the closest relatives to animals and fourth, that cell death occurs in response to cyclic dinucleotides.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

   Reviewed by eLife, preLights

3. Multi-scale spatial heterogeneity enhances particle clearance in airway ciliary arrays

   This article has 6 authors:

   1. Guillermina R. Ramirez-San Juan
   2. Arnold J. T. M. Mathijssen
   3. Mu He
   4. Lily Jan
   5. Wallace Marshall
   6. Manu Prakash

   Reviewed by preLights

4. High survival following bleaching highlights the resilience of a highly disturbed region of the Great Barrier Reef

   This article has 4 authors:

   1. Cathie A Page
   2. Christine Giuliano
   3. Line K Bay
   4. Carly J Randall

   Reviewed by preLights

5. Single-cell transcriptomic characterization of a gastrulating human embryo

   This article has 6 authors:

   1. Richard C. V. Tyser
   2. Elmir Mahammadov
   3. Shota Nakanoh
   4. Ludovic Vallier
   5. Antonio Scialdone
   6. Shankar Srinivas

   Reviewed by preLights

6. Antlions are sensitive to subnanometer amplitude vibrations carried by sand substrates

   This article has 4 authors:

   1. Vanessa Martinez
   2. Elise Nowbahari
   3. David Sillam-Dussès
   4. Vincent Lorent

   Reviewed by preLights

7. Utah-Stanford Ventilator (Vent4US): Developing a rapidly scalable ventilator for COVID-19 patients with ARDS

   This article has 14 authors:

   1. Hongquan Li
   2. Ethan Li
   3. Deepak Krishnamurthy
   4. Patrick Kolbay
   5. Beca Chacin
   6. Soeren Hoehne
   7. Jim Cybulski
   8. Lara Brewer
   9. Tomasz Petelenz
   10. Joseph Orr
   11. Derek Sakata
   12. Thomas Clardy
   13. Kai Kuck
   14. Manu Prakash

   Reviewed by ScreenIT, preLights

8. Evolutionary Changes in Left-Right Visceral Asymmetry in Astyanax Cavefish

   This article has 7 authors:

   1. Li Ma
   2. Mandy Ng
   3. Janet Shi
   4. Aniket V. Gore
   5. Daniel Castranova
   6. Brant M. Weinstein
   7. William R. Jeffery

   Reviewed by preLights

9. Live-cell single particle tracking of PRC1 reveals a highly dynamic system with low target site occupancy

   This article has 2 authors:

   1. Miles K. Huseyin
   2. Robert J. Klose

   Reviewed by preLights

10. Tumors Exploit Dedicated Intracellular Vesicles to Program T cell Responses

    This article has 10 authors:

    1. Edward W. Roberts
    2. Megan K. Ruhland
    3. En Cai
    4. Adriana M. Mujal
    5. Kyle Marchuk
    6. Casey Beppler
    7. David Nam
    8. Nina K. Serwas
    9. Mikhail Binnewies
    10. Matthew F. Krummel

    Reviewed by preLights