eLife

Latest preprint reviews

1. Distinct aging-vulnerable trajectories of motor circuit functions in oxidation- and temperature-stressed Drosophila

   This article has 3 authors:

   1. Atulya Srisudarshan Ram Iyengar
   2. Hongyu Ruan
   3. Chun-Fang Wu

   This article has been curated by 1 group:

   • Curated by eLife

     Summary: Overall, this technically challenging and well executed study provides a nice description of the effects of aging, high activity (induced by higher temperature), and loss of SOD function on the neurophysiology of the GF system in Drosophila. However, most of the effects described have been observed in other systems. The authors have not adequately controlled for genetic background in their observations and have not carefully considered development effects. At this stage, the study does not provide insight into the mechanisms underlying the age-dependent alterations of the examined neurons.

   Reviewed by eLife

2. Local projections of layer Vb-to-Va are more effective in lateral than in medial entorhinal cortex

   This article has 7 authors:

   1. Shinya Ohara
   2. Stefan Blankvoort
   3. Rajeevkumar R. Nair
   4. Maximiliano J. Nigro
   5. Eirik S. Nilssen
   6. Clifford Kentros
   7. Menno P. Witter

   This article has been curated by 1 group:

   • Curated by eLife

     Summary: The study addresses a fundamentally important question regarding the connectivity of LVb and LVa in the medial and lateral entorhinal cortex. The authors suggest that LVb to LVa connection exists in the LEC but not in the MEC. This finding would have important implications on studies investigating circuits functions between the hippocampus and the EC. All three reviewers found the central question important and the data novel. However, there are several technical issues that limit the robustness of the authors claim.

     1. While the transgenic animal used in these experiments is elegant and novel, it only labels a subpopulation of the neurons. There is a possibility of selective labelling of neurons with distinct connectivity patterns. The authors would need to show that their approach is not leading to false negative results due to the selective visualization of those neurons that project more modestly to the LVa.

     2. The specificity of the injection to the LEC/MEC should be better documented and potential spread to the perirhinal or postrhinal cortex carefully excluded.

     3. The findings are presented as LVb to LVa connection did not exist at all in the MEC, however the data shows that the connection is there but it is significantly less dense than in the LEC. Given the graded finding, if the authors aim to show their central claim regarding the lack of mediation of hippocampo-cortical outputs by this connection in the MEC, this would require the addition of functional studies.

   Reviewed by eLife

3. Rescuing Auditory Temporal Processing with a Novel Augmented Acoustic Environment in an Animal Model of Congenital Hearing Loss

   This article has 4 authors:

   1. Adam C. Dziorny
   2. Anne E. Luebke
   3. Luisa L. Scott
   4. Joseph P. Walton

   This article has been curated by 1 group:

   • Curated by eLife

     Summary: The reviewer and the editors both recognize that the study suggests a clear improvement of auditory sensitivity, at least to gaps, with early temporal enrichment, and agree on the quality of the work performed. However, the improvements brought by the new paradigm are small and not supported by strong statistics. Overall also this study seems sound but too specialized for a broader readership.

   Reviewed by eLife

4. Responsiveness variability during anaesthesia relates to inherent differences in brain structure and function of the fronto-parietal networks

   This article has 5 authors:

   1. Feng Deng
   2. Nicola Taylor
   3. Adrian M. Owen
   4. Rhodri Cusack
   5. Lorina Naci

   Reviewed by eLife

5. Axonal ER Ca ²⁺ Release Enhances Miniature, but Reduces Activity-Dependent Glutamate Release in a Huntington Disease Model

   This article has 10 authors:

   1. James P. Mackay
   2. Amy I. Smith-Dijak
   3. Ellen T. Koch
   4. Peng Zhang
   5. Evan Fung
   6. Wissam B. Nassrallah
   7. Caodu Buren
   8. Mandi Schmidt
   9. Michael R. Hayden
   10. Lynn A. Raymond

   Reviewed by eLife

6. SARS-CoV-2 nucleocapsid protein forms condensates with viral genomic RNA

   This article has 11 authors:

   1. Amanda Jack
   2. Luke S. Ferro
   3. Michael J. Trnka
   4. Eddie Wehri
   5. Amrut Nadgir
   6. Xammy Huu Wrynla
   7. Douglas Fox
   8. Katelyn Costa
   9. Sarah Stanley
   10. Julia Schaletzky
   11. Ahmet Yildiz

   Reviewed by eLife, ScreenIT

7. Susceptibility rhythm to bacterial endotoxin in myeloid clock-knockout mice

   This article has 5 authors:

   1. Veronika Lang
   2. Sebastian Ferencik
   3. Bharath Ananthasubramaniam
   4. Achim Kramer
   5. Bert Maier

   Reviewed by eLife

8. Independent mechanisms of temporal and linguistic cue correspondence benefiting audiovisual speech processing

   This article has 3 authors:

   1. Sara Fiscella
   2. Madeline S Cappelloni
   3. Ross K Maddox

   Reviewed by eLife

9. Sleep-learning impairs subsequent awake-learning

   This article has 3 authors:

   1. Simon Ruch
   2. Marc Alain Züst
   3. Katharina Henke

   Reviewed by eLife

10. Redefining De Novo Gammaherpesvirus Infection Through High-Dimensional, Single-Cell Analysis of Virus and Host

    This article has 9 authors:

    1. Jennifer N. Berger
    2. Bridget Sanford
    3. Abigail K. Kimball
    4. Lauren M. Oko
    5. Rachael E. Kaspar
    6. Brian F. Niemeyer
    7. Kenneth L. Jones
    8. Eric T. Clambey
    9. Linda F. van Dyk

    Reviewed by eLife