eLife

Latest preprint reviews

1. Bundle-specific associations between white matter microstructure and Aβ and tau pathology at their connecting cortical endpoints in older adults at risk of Alzheimer’s disease

   This article has 10 authors:

   1. Alexa Pichet Binette
   2. Guillaume Theaud
   3. François Rheault
   4. Maggie Roy
   5. D. Louis Collins
   6. John C.S. Breitner
   7. Judes Poirier
   8. Maxime Descoteaux
   9. Sylvia Villeneuve
   10. for the PREVENT-AD Research Group

   This article has been curated by 1 group:

   • Curated by eLife

     Summary: As you will find below, all three reviewers provided very positive technical reviews - there was a strong consensus that this is a well-executed study. The reviewers highlighted the large cohort of participants, the innovative and versatile use of neuroimaging techniques, and in particular the water-corrected diffusion and tau-PET measures, and the careful analysis. While we acknowledge these methodological strengths, we found it difficult to agree on the validity of the interpretation of the findings, considering the unexpected directionality of the results. In addition, we felt that without additional proof-of-concept (e.g. longitudinal study), the current experimental design does not provide sufficient evidence for an early brain pathology marker. However, it was agreed that the study provides a clear advancement relative to other studies looking at the relationship between different imaging domains in AD. As such, the present findings should be particularly valuable for an audience interested in white-matter pathology in neurodegenerative diseases.

   Reviewed by eLife

2. Asymmetric Functional Gradients in the Human Subcortex

   This article has 5 authors:

   1. Xavier Guell
   2. Jeremy D Schmahmann
   3. John DE Gabrieli
   4. Satrajit S Ghosh
   5. Maiya R Geddes

   This article has been curated by 1 group:

   • Curated by eLife

     Summary: This study investigates asymmetry in functional gradients in human thalamus, striatum and cerebellum. The authors found that the thalamus and the pallidum of the lenticular nucleus have strongly asymmetric principal functional gradients across the two hemispheres. In the case of the caudate and cerebellum, their 2nd and 3rd gradients were asymmetric. In general, the reviewers and editors found the study to be intriguing, but ultimately, felt that the dichotomous model, while interesting, was too speculative with no direct evidence presented. Considering also the lack of results on the functional significance of the asymmetries, the editors and reviewers felt that the study is better suited for a more specialized audience.

   Reviewed by eLife

3. Extreme suction attachment performance from specialised insects living in mountain streams (Diptera: Blephariceridae)

   This article has 4 authors:

   1. Victor Kang
   2. Robin T White
   3. Simon Chen
   4. Walter Federle

   Reviewed by eLife

4. Bayesian inference of kinetic schemes for ion channels by Kalman filtering

   This article has 4 authors:

   1. Jan L Münch
   2. Fabian Paul
   3. Ralf Schmauder
   4. Klaus Benndorf

   This article has been curated by 1 group:

   • Curated by eLife

     Summary: The manuscript is well written and overall clear, and the mathematical treatment is a rigorous tour-de-force. However, the reviewers raised a number of points that need further clarification, better discussion or amendment. These concerns are likely to be addressable largely by changes to the main text and software documentation along with some additional analyses. The study is very nice and ambitious, but clarity is a bit impaired by dealing with perhaps too many issues. The state inference and the bayesian model selection are very important but completely different issues. The authors should consider whether they may be better treated separately, or for a more specialized audience.

   Reviewed by eLife

5. Local circuit allowing hypothalamic control of hippocampal area CA2 activity and consequences for CA1

   This article has 11 authors:

   1. Vincent Robert
   2. Ludivine Therreau
   3. Vivien Chevaleyre
   4. Eude Lepicard
   5. Cécile Viollet
   6. Julie Cognet
   7. Arthur JY Huang
   8. Roman Boehringer
   9. Denis Polygalov
   10. Thomas J McHugh
   11. Rebecca Ann Piskorowski

   This article has been curated by 1 group:

   • Curated by eLife

     Summary: The study describes the properties of inputs from the supramammillary nucleus (SuM) to the CA2 area of the hippocampus. Novel information is presented by the influence of the SuM input on the local hippocampal network in the CA2 and what the effect of this input is on network activity in the CA1. The authors use complementary methods to address this question including patch-clamp recordings and optogenetics. Overall the reviewers found this study important, the experiments well-designed and the data of high quality. However, there are several key points raised by the reviewers to strengthen the data in order to fully support the authors' conclusions, and addressing these will require additional experimental work. The list below summarizes the list of required experiments reviewers agreed would be necessary for having full confidence in the authors' conclusions:

     1. The authors would need to show the effect of SuM stimulation on synaptically triggered APs and not only on Aps evoked with a current step.

     2. The change in the balance of EPCs and IPSCs in a train should be demonstrated in a single cell.

     3. The properties of monosynaptic/disynaptic events should be compared and the lack of direct GABAergic input from the SuM demonstrated. The authors should quantify the delay time to light-evoked IPSCs to address whether the SuM-CA2 inputs are forming monosynaptic or disynaptic GABAergic connections to pyramidal neurons, as it is possible SuM neurons co-release glutamate and GABA to CA2. Given the importance of the mono vs. disynaptic innervation of different types of cells, the authors should go beyond the TTX experiments (as TTX would block a disynaptic EPSC) and also use 4-AP to recover the TTX blocked current to unequivocally prove that they inputs are monosynaptic.

     4. The preferential role of PV+ cells should be shown with a more selective pharmacological approach.

     5. The authors should elaborate on how SuM stimulation influences theta/gamma rhythms in the CA1 area.

     This manuscript is under revision at eLife.

   Reviewed by eLife

6. Expansin-controlled cell wall stiffness regulates root growth in Arabidopsis

   This article has 10 authors:

   1. Marketa Samalova
   2. Kareem Elsayad
   3. Alesia Melnikava
   4. Alexis Peaucelle
   5. Evelina Gahurova
   6. Jaromir Gumulec
   7. Ioannis Spyroglou
   8. Elena V. Zemlyanskaya
   9. Elena V. Ubogoeva
   10. Jan Hejatko

   This article has been curated by 1 group:

   • Curated by eLife

     Summary: The reviewers felt that this is important work because in vivo characterization of expansins has lagged far behind their in vitro characterization. However, both reviewers also made important points about additional controls and statistical comparisons that are required to fully interpret and appreciate the results that are presented here. It seems that the role of expansins in the plant cell wall may be complex and nuanced. However, it is clear from the author's discussion of their results that significant further experimentation is required to bring new insight to the function of expansins in mediating plant root growth.

   Reviewed by eLife

7. Auditory detection is modulated by theta phase of silent lip movements

   This article has 5 authors:

   1. Emmanuel Biau
   2. Danying Wang
   3. Hyojin Park
   4. Ole Jensen
   5. Simon Hanslmayr

   This article has been curated by 1 group:

   • Curated by eLife

     Summary: The reviewers agreed that the paradigm proposed in this work is elegant, and the question timely and important. However, as detailed below, they highlighted several concerns about analysis choices and the interpretation of the data. While some of these can be addressed, it was felt that a major drawback of the present manuscript is that the behaviour and EEG are obtained separately and any links are hence only circumstantial.

   Reviewed by eLife

8. Detecting fine and elaborate movements with piezo sensors, from heartbeat to the temporal organization of behavior

   This article has 11 authors:

   1. Maria Isabel Carreño-Muñoz
   2. Maria Carmen Medrano
   3. Thomas Leinekugel
   4. Maelys Bompart
   5. Fabienne Martins
   6. Enejda Subashi
   7. Franck Aby
   8. Andreas Frick
   9. Marc Landry
   10. Manuel Grana
   11. Xavier Leinekugel

   This article has been curated by 1 group:

   • Curated by eLife

     Summary: The need to easily measure spontaneous behaviors in a robust fashion in experimental animals is an important problem in behavioral neuroscience. Thus, while this study is timely, the reviewers found fundamental flaws that substantially dampen enthusiasm for this work. The collective major concerns are: 1) the advance provided by this system, relative to already existing and commercially available software based on similar principles, was not clear, 2) critical technical details describing this system are missing 3) the diverse biological applications were not explored with sufficient depth and many of the related claims had potential alternative explanations.

   Reviewed by eLife

9. Fungal microbiomes are determined by host phylogeny and exhibit widespread associations with the bacterial microbiome

   This article has 41 authors:

   1. Xavier A. Harrison
   2. Allan D. McDevitt
   3. Jenny C. Dunn
   4. Sarah Griffiths
   5. Chiara Benvenuto
   6. Richard Birtles
   7. Jean P. Boubli
   8. Kevin Bown
   9. Calum Bridson
   10. Darren Brooks
   11. Samuel S. Browett
   12. Ruth F. Carden
   13. Julian Chantrey
   14. Friederike Clever
   15. Ilaria Coscia
   16. Katie L. Edwards
   17. Natalie Ferry
   18. Ian Goodhead
   19. Andrew Highlands
   20. Jane Hopper
   21. Joseph Jackson
   22. Robert Jehle
   23. Mariane da Cruz Kaizer
   24. Tony King
   25. Jessica M. D. Lea
   26. Jessica L. Lenka
   27. Alexandra McCubbin
   28. Jack McKenzie
   29. Bárbara Lins Caldas de Moraes
   30. Denise B. O’Meara
   31. Poppy Pescod
   32. Richard F. Preziosi
   33. Jennifer K. Rowntree
   34. Susanne Shultz
   35. Matthew J. Silk
   36. Jennifer E. Stockdale
   37. William O. C. Symondson
   38. Mariana Villalba de la Pena
   39. Susan L. Walker
   40. Michael D. Wood
   41. Rachael E. Antwis

   Reviewed by eLife

10. Cardiolipin targets a dynamin-related protein to the nuclear membrane

    This article has 3 authors:

    1. Usha Pallabi Kar
    2. Himani Dey
    3. Abdur Rahaman

    Reviewed by eLife, Review Commons