eLife

Latest preprint reviews

1. Quantitative live-cell imaging and computational modeling shed new light on endogenous WNT/CTNNB1 signaling dynamics

   This article has 5 authors:

   1. Saskia MA de Man
   2. Gooitzen Zwanenburg
   3. Tanne van der Wal
   4. Mark A Hink
   5. Renée van Amerongen

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Wnt signaling plays critical roles in cell fate determination in essentially every tissue in all animals, regulates tissue homeostasis in many adult tissues, and is inappropriately activated in many human cancers. It has been the focus of research for decades, and we have an outline of signal transduction. Remarkably, some of the key questions of Wnt signaling remain controversial. Central among these are questions about the nature of the negative regulatory destruction complex, its mechanism of action and how it is turned down by Wnt signaling. Here Saskia and colleagues take a novel and very exciting approach to these questions, combining innovative quantitative live-cell imaging and computational modelling.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

   Reviewed by eLife

2. The half-life of the bone-derived hormone osteocalcin is regulated through O-glycosylation in mice, but not in humans

   This article has 8 authors:

   1. Omar Al Rifai
   2. Catherine Julien
   3. Julie Lacombe
   4. Denis Faubert
   5. Erandi Lira-Navarrete
   6. Yoshiki Narimatsu
   7. Henrik Clausen
   8. Mathieu Ferron

   Reviewed by eLife

3. Organization of DNA Replication Origin Firing in Xenopus Egg Extracts: The Role of Intra-S Checkpoint

   This article has 8 authors:

   1. Diletta Ciardo
   2. Olivier Haccard
   3. Hemalatha Narassimprakash
   4. Jean-Michel Arbona
   5. Olivier Hyrien
   6. Benjamin Audit
   7. Kathrin Marheineke
   8. Arach Goldar

   Reviewed by eLife

4. Structure of the bacterial ribosome at 2 Å resolution

   This article has 7 authors:

   1. Zoe L Watson
   2. Fred R Ward
   3. Raphaël Méheust
   4. Omer Ad
   5. Alanna Schepartz
   6. Jillian F Banfield
   7. Jamie HD Cate

   Reviewed by eLife

5. Dipeptidyl peptidase 9 triggers BRCA2 degradation and promotes DNA damage repair

   This article has 18 authors:

   1. Oguz Bolgi
   2. Maria Silva‐Garcia
   3. Breyan Ross
   4. Esther Pilla
   5. Vijayalakshmi Kari
   6. Markus Killisch
   7. Melanie Spitzner
   8. Nadine Stark
   9. Christof Lenz
   10. Konstantin Weiss
   11. Laura Donzelli
   12. Mark D Gorrell
   13. Marian Grade
   14. Jan Riemer
   15. Henning Urlaub
   16. Matthias Dobbelstein
   17. Robert Huber
   18. Ruth Geiss‐Friedlander

   Reviewed by eLife

6. Comparison of induced neurons reveals slower structural and functional maturation in humans than in apes

   This article has 12 authors:

   1. Maria Schörnig
   2. Xiangchun Ju
   3. Luise Fast
   4. Sebastian Ebert
   5. Anne Weigert
   6. Sabina Kanton
   7. Theresa Schaffer
   8. Nael Nadif Kasri
   9. Barbara Treutlein
   10. Benjamin Marco Peter
   11. Wulf Hevers
   12. Elena Taverna

   Reviewed by eLife

7. Effects of Early Life Stress on Bone Homeostasis in Mice and Humans

   This article has 13 authors:

   1. Karin Wuertz-Kozak
   2. Martin Roszkowski
   3. Elena Cambria
   4. Andrea Block
   5. Gisela A. Kuhn
   6. Thea Abele
   7. Wolfgang Hitzl
   8. David Drießlein
   9. Ralph Müller
   10. Michael A. Rapp
   11. Isabelle M. Mansuy
   12. Eva M. J. Peters
   13. Pia M. Wippert

   Reviewed by eLife

8. Predicting the retinotopic organization of human visual cortex from anatomy using geometric deep learning

   This article has 3 authors:

   1. Fernanda L. Ribeiro
   2. Steffen Bollmann
   3. Alexander M. Puckett

   Reviewed by eLife

9. Arrayed CRISPRi and quantitative imaging describe the morphotypic landscape of essential mycobacterial genes

   This article has 5 authors:

   1. Timothy J de Wet
   2. Kristy R Winkler
   3. Musa Mhlanga
   4. Valerie Mizrahi
   5. Digby F Warner

   Reviewed by eLife

10. Vascular control of the CO2/H+-dependent drive to breathe

    This article has 6 authors:

    1. Colin M Cleary
    2. Thiago S Moreira
    3. Ana C Takakura
    4. Mark T Nelson
    5. Thomas A Longden
    6. Daniel K Mulkey

    Reviewed by eLife