eLife

Latest preprint reviews

1. Adiponectin Preserves Metabolic Fitness During Aging

   This article has 18 authors:

   1. Na Li
   2. Zhuzhen Zhang
   3. Shangang Zhao
   4. Yi Zhu
   5. Christy M. Gliniak
   6. Lavanya Vishvanath
   7. Yu A. An
   8. May-yun Wang
   9. Yingfeng Deng
   10. Qingzhang Zhu
   11. Toshiharu Onodera
   12. Orhan K Oz
   13. Ruth Gordillo
   14. Rana K. Gupta
   15. Ming Liu
   16. Tamas L. Horvath
   17. Vishwa Deep Dixit
   18. Philipp E. Scherer

   Reviewed by eLife

2. Graded spikes differentially signal neurotransmitter input in cerebrospinal fluid contacting neurons of the mouse spinal cord

   This article has 8 authors:

   1. Emily Johnson
   2. Marilyn Clark
   3. Merve Oncul
   4. Andreea Pantiru
   5. Claudia MacLean
   6. Jim Deuchars
   7. Susan A. Deuchars
   8. Jamie Johnston

   This article has been curated by 1 group:

   • Curated by eLife

     Summary: The reviewers have found the topic of your study of high interest, with very intriguing findings on the different origins of calcium transients in CSFcNs.

     However, after a careful examination of your work , the reviewers have raised the following major concerns:

     1. To conclude on calcium spikes, the imaging data without electrophysiological calibration leaves too much unknown. A careful electrophysiological examination should reveal how calcium transients of different amplitude correlate with the electrical activity of the cell, calcium spikes and spontaneous PKD2L1 channel openings as described extensively in these cells, is absolutely mandatory to conclude.

     2. The manuscript shows a lack of consideration of the importance of the sensory functions and of the role of channel PKDL1 that are both well-established in CSFcNs in mice and other models. More work is necessary to relate to these critical aspects.

     3. The number of animals for juvenile and adult mice used by the authors should be clearly stated (the manuscript only refers to the total number) but also largely increased for the authors to reach robust conclusions.

     4. Overall, more rigor should be implemented throughout the entire manuscript, with a deep writing improvement and a careful inspection of figure panels (choice and fair / complete representation of the data) and more information on conditions used for experiments (promoter used, concentrations for pharmacological agents, selection of ROIs, ventral versus dorsal CSF-cNs, definition and proportion of silent cells, enrichment in the T and L type calcium channels, etc ... ).

     Reviewer #2 and Reviewer #4 opted to reveal their name to the authors in the decision letter after review.

   Reviewed by eLife

3. Metformin alleviates stress-induced cellular senescence of aging human adipose stromal cells and the ensuing adipocyte dysfunction

   This article has 12 authors:

   1. Laura Le Pelletier
   2. Matthieu Mantecon
   3. Jennifer Gorwood
   4. Martine Auclair
   5. Roberta Foresti
   6. Roberto Motterlini
   7. Mireille Laforge
   8. Michael Atlan
   9. Bruno Fève
   10. Jacqueline Capeau
   11. Claire Lagathu
   12. Veronique Bereziat

   Reviewed by eLife

4. A naturalistic environment to study visual cognition in unrestrained monkeys

   This article has 6 authors:

   1. Georgin Jacob
   2. Harish Katti
   3. Thomas Cherian
   4. Jhilik Das
   5. KA Zhivago
   6. SP Arun

   This article has been curated by 1 group:

   • Curated by eLife

     Summary: This manuscript describes a new experimental environment for training macaque monkeys to perform behavioral tasks. Using this facility, the authors trained freely moving macaques to perform a visual "same-different" task using operant conditioning, and under voluntary head restraint. The authors demonstrate that they could obtain reliable eye-tracking data and high-performance accuracy from macaques in this facility. They also noted that subordinate macaques can learn to perform basic aspects of the task by observing their dominant conspecifics perform the task in this facility. The authors conclude that this naturalistic environment can facilitate the study of brain activity during natural and controlled behavioral tasks.

     The manuscript is broadly organized along three distinct lines of inquiry. First, the authors describe a customized living space for a small group of macaque monkeys. Second, the authors train two of these monkeys to perform a cognitive task in a purpose-built room of the living enclosure. Third, the authors describe their experience training a third monkey to complete the cognitive task.

   Reviewed by eLife

5. Collateral sensitivity associated with antibiotic resistance plasmids

   This article has 7 authors:

   1. Cristina Herencias
   2. Jerónimo Rodríguez-Beltrán
   3. Ricardo León-Sampedro
   4. Aida Alonso-del Valle
   5. Jana Palkovičová
   6. Rafael Cantón
   7. Álvaro San Millán

   Reviewed by eLife

6. Occurrence of foamy macrophages during the innate response of zebrafish to trypanosome infections

   This article has 7 authors:

   1. Sem H Jacobs
   2. Eva Dóró
   3. Ffion R Hammond
   4. Mai E Nguyen-Chi
   5. Georges Lutfalla
   6. Geert F Wiegertjes
   7. Maria Forlenza

   This article has been curated by 1 group:

   • Curated by eLife

     Summary: This study investigates the role of the innate immune response in controlling bloodstream trypanosome infection in the zebrafish infection model recently developed by the authors. The study found that an innate immune response, characterized by controlled inflammatory response was sufficient to control infection in some individuals, while failure to control infection was associated with a strong inflammatory response characterized by expansion of foamy macrophages. The findings highlight the importance of a balanced immune response in controlling bloodstream trypanosome infections that are likely relevant to mammalian infections.

     Reviewer #1 and Reviewer #2 opted to reveal their name to the authors in the decision letter after review.

   Reviewed by eLife

7. Surprising phenotypic diversity of cancer-associated mutations of Gly 34 in the histone H3 tail

   This article has 13 authors:

   1. Brandon R Lowe
   2. Rajesh K Yadav
   3. Ryan A Henry
   4. Patrick Schreiner
   5. Atsushi Matsuda
   6. Alfonso G Fernandez
   7. David Finkelstein
   8. Margaret Campbell
   9. Satish Kallappagoudar
   10. Carolyn M Jablonowski
   11. Andrew J Andrews
   12. Yasushi Hiraoka
   13. Janet F Partridge

   Reviewed by eLife

8. Mitochondrial respiration contributes to the interferon gamma response in antigen-presenting cells

   This article has 7 authors:

   1. Michael C Kiritsy
   2. Katelyn McCann
   3. Daniel Mott
   4. Steven M Holland
   5. Samuel M Behar
   6. Christopher M Sassetti
   7. Andrew J Olive

   Reviewed by eLife

9. Evolution of cytokine production capacity in ancient and modern European populations

   This article has 11 authors:

   1. Jorge Domínguez-Andrés
   2. Yunus Kuijpers
   3. Olivier B Bakker
   4. Martin Jaeger
   5. Cheng-Jian Xu
   6. Jos WM Van der Meer
   7. Mattias Jakobsson
   8. Jaume Bertranpetit
   9. Leo AB Joosten
   10. Yang Li
   11. Mihai G Netea

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Dominguez-Andrés et al. collect a large amount of immune-related trait association data from a cohort made up of 534 individuals of Western European ancestry. The goal was to track the evolutionary trajectories of cytokine production capacity over time in a number of patients with different exposure to infectious organisms, infectious disease, autoimmune and inflammatory diseases, using the 500 Functional Genomics cohort of the Human Functional Genomics Project. From this analysis it was hypothesized that the Neolithic transition was characterized by strong changes in the adaptive response to pathogens in human biology. Overall, the manuscript is interesting but could be improved by significant enhancements to statistical methodology.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

   Reviewed by eLife

10. A genetic screen in macrophages identifies new regulators of IFNγ-inducible MHCII that contribute to T cell activation

    This article has 9 authors:

    1. Michael C Kiritsy
    2. Laurisa M Ankley
    3. Justin Trombley
    4. Gabrielle P Huizinga
    5. Audrey E Lord
    6. Pontus Orning
    7. Roland Elling
    8. Katherine A Fitzgerald
    9. Andrew J Olive

    Reviewed by eLife