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  3. Fascin limits Myosin activity within Drosophila border cells to control substrate stiffness and promote migration

    1. Maureen C Lamb
    2. Chathuri P Kaluarachchi
    3. Thiranjeewa I Lansakara
    4. Samuel Q Mellentine
    5. Yiling Lan
    6. Alexei V Tivanski
    7. Tina L Tootle

    • Curated by eLife

      Evaluation Summary:

      This manuscript explores the relationship between stiffness of migrating cells and the stiffness of the substrate of which they are migrating. Specifically, the authors show that the actin-bundling protein Fascin limits the levels of activated myosin to alter stiffness of the migratory substrate. This is a well-controlled study, and with some additional clarifications of methods and extensions to some analyses that would strengthen the paper, it will be of broad interest to cell biologists, particularly those studying cell migration.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #3 agreed to share their names with the authors.)

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  4. Information flows from hippocampus to auditory cortex during replay of verbal working memory items

    1. Vasileios Dimakopoulos
    2. Pierre Mégevand
    3. Lennart H Stieglitz
    4. Lukas Imbach
    5. Johannes Sarnthein

    • Curated by eLife

      Evaluation Summary:

      The basis for working memory is controversial in terms of any basis related to neuronal or synaptic activity in sensory cortex during maintenance and the involvement of non-sensory areas especially the frontal cortex and hippocampus. This work uses rare human intracranial recordings to examine another aspect, connectivity between areas, and demonstrates connectivity from sensory cortex to hippocampus during encoding in one frequency band and connectivity in a reverse sense during maintenance. The work has the potential to inform models of working memory.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  6. Structure and mechanistic features of the prokaryotic minimal RNase P

    1. Rebecca Feyh
    2. Nadine B Waeber
    3. Simone Prinz
    4. Pietro Ivan Giammarinaro
    5. Gert Bange
    6. Georg Hochberg
    7. Roland K Hartmann
    8. Florian Altegoer

    • Curated by eLife

      Evaluation Summary:

      This manuscript provides the first 3D structure of a novel type of RNA processing enzyme recently identified in bacteria. It convincingly uses cryoEM and biochemistry to describe how this small enzyme makes a new type of homo polymeric complex as required for its activity. The manuscript provides important conceptual novelties that will be of interest for a broad readership of biologists interested in gene expression processes.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

    Reviewed by eLife

    2 evaluationsAppears in 1 listLatest version Latest activity

  7. SMRT and NCoR1 fine-tune inflammatory versus tolerogenic balance in dendritic cells by differentially regulating STAT3 signaling

    1. Atimukta Jha
    2. Abdul Ahad
    3. Gyan Prakash Mishra
    4. Kaushik Sen
    5. Shuchi Smita
    6. Aliva Prity Minz
    7. Viplov Kumar Biswas
    8. Archana Tripathy
    9. Shantibhushan Senapati
    10. Bhawna Gupta
    11. Hans Acha-Orbea
    12. Sunil Kumar Raghav

    • Curated by eLife

      Evaluation Summary:

      This paper is of interest to immunologists studying the transcriptional control of innate immune responses. The paper presents a new role for transcriptional regulators in the control of inflammatory properties of cross-presenting dendritic cells that are involved in anti-tumoral and anti-viral immunity. The data support the conclusions but some modifications of the text and additional experiments are required.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity

  10. Niche partitioning facilitates coexistence of closely related honey bee gut bacteria

    1. Silvia Brochet
    2. Andrew Quinn
    3. Ruben AT Mars
    4. Nicolas Neuschwander
    5. Uwe Sauer
    6. Philipp Engel

    • Curated by eLife

      Evaluation Summary:

      Brochet et al. address an outstanding ecological question related to how closely related microbial symbionts co-exist in the gut as stable communities. To tackle this question, the authors use an elegant model relying on honeybees colonized with a defined bacterial community. They provide compelling empirical evidence that a nutritionally complex diet together with microbial metabolic diversity play a key role in enabling co-existence of closely-related honeybee gut microbiota.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

    Reviewed by eLife

    5 evaluationsAppears in 1 listLatest version Latest activity
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