eLife

Latest preprint reviews

1. Direct extraction of signal and noise correlations from two-photon calcium imaging of ensemble neuronal activity

   This article has 6 authors:

   1. Anuththara Rupasinghe
   2. Nikolas Francis
   3. Ji Liu
   4. Zac Bowen
   5. Patrick O Kanold
   6. Behtash Babadi

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This article is of general interest to scientists who perform two-photon calcium imaging in vivo and explore the link between function and structure in real neural networks. The development of efficient approaches to estimate true correlations between large sets of noisy individual neurons based on realistic and thus limited observation time is a key to better understand functional local circuits. The effectiveness of the proposed method is illustrated by simulations and applied on real data, but several steps in its procedure remain to be clarified in the current form of the manuscript to be usable by a wide range of users.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

2. A mechanism with severing near barbed ends and annealing explains structure and dynamics of dendritic actin networks

   This article has 6 authors:

   1. Danielle Holz
   2. Aaron R Hall
   3. Eiji Usukura
   4. Sawako Yamashiro
   5. Naoki Watanabe
   6. Dimitrios Vavylonis

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     In this work, Holz and colleagues develop a computational stochastic model of lamellipodial actin network growth and turnover to address an unresolved important question: how do these networks remain wide enough, maintain angular order, and actually increase the filament length behind the leading edge? They compare the filament organization and rate of incorporation/detachment of actin subunits with experimental data published in the literature. A main result from this study is that frequent filament fragmentation and annealing are key events in the reorganization of branched actin networks. The paper is well written, contains very thorough and fair literature review, is accurate, well documented. The result is novel and significant.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

   Reviewed by eLife

3. Persistent cell migration emerges from a coupling between protrusion dynamics and polarized trafficking

   This article has 6 authors:

   1. Kotryna Vaidžiulytė
   2. Anne-Sophie Macé
   3. Aude Battistella
   4. William Beng
   5. Kristine Schauer
   6. Mathieu Coppey

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Cell movement is essential for development and tissue homeostasis. While the cellular machineries involved in movement have been well studied, how cells maintain a persistent direction of motion is less well understood. Here, Coppey's team shows that movement persistence emerges from the coupling of two cellular systems: protrusions at the leading edge and polarity of secretion. This coupling is controlled by the small GTPase Cdc42. The authors propose a physical model that recapitulates the coupling, defines two key parameters and explains persistent cell migration.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their names with the authors.)

   Reviewed by eLife

4. Modelling the impact of decidual senescence on embryo implantation in human endometrial assembloids

   This article has 12 authors:

   1. Thomas M Rawlings
   2. Komal Makwana
   3. Deborah M Taylor
   4. Matteo A Molè
   5. Katherine J Fishwick
   6. Maria Tryfonos
   7. Joshua Odendaal
   8. Amelia Hawkes
   9. Magdalena Zernicka-Goetz
   10. Geraldine M Hartshorne
   11. Jan J Brosens
   12. Emma S Lucas

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This manuscript is of broad interest to scientists in the field of reproduction and has clinical relevance. It builds on innovative studies interrogating the impact of cell senescence on stromal cell differentiation and embryo implantation. It presents the development of a novel co-culture system taking advantage of organoid technology to study cell-specific interactions and outcomes.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewers #1, #2, and #3 agreed to share their names with the authors.)

   Reviewed by eLife

5. A bidirectional corticoamygdala circuit for the encoding and retrieval of detailed reward memories

   This article has 11 authors:

   1. Ana C Sias
   2. Ashleigh K Morse
   3. Sherry Wang
   4. Venuz Y Greenfield
   5. Caitlin M Goodpaster
   6. Tyler M Wrenn
   7. Andrew M Wikenheiser
   8. Sandra M Holley
   9. Carlos Cepeda
   10. Michael S Levine
   11. Kate M Wassum

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This study examined the neural mechanism underlying stimulus-outcome associations. Using a series of sophisticated experiments with otpogenetics and pharmacogenetics, the authors show that interactions between the basolateral amygdala (BLA) and the lateral part of the orbitofrontal cortex (lOFC) play critical role in learning to predict the identity of outcome predicted by a cue, but not in learning to predict reward generally. These results extend our understanding of how BLA and lOFC regulate the formation of associative learning and subsequent decision-making.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

6. A functional topography within the cholinergic basal forebrain for encoding sensory cues and behavioral reinforcement outcomes

   This article has 7 authors:

   1. Blaise Robert
   2. Eyal Y Kimchi
   3. Yurika Watanabe
   4. Tatenda Chakoma
   5. Miao Jing
   6. Yulong Li
   7. Daniel B Polley

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This paper will be of interest to neuroscientists studying the effects of cholinergic modulation throughout the brain. It provides strong support for the view that activity in the basal forebrain cholinergic system is not monolithic, but varies across the rostrocaudal axis, consistent with previous reports of differential connectivity of these areas. Strong evidence for regional differences in cholinergic responses collected simultaneously under multiple behavioral conditions provides valuable context for interpreting variability in existing and future studies.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

7. Targeting an anchored phosphatase-deacetylase unit restores renal ciliary homeostasis

   This article has 10 authors:

   1. Janani Gopalan
   2. Mitchell H Omar
   3. Ankita Roy
   4. Nelly M Cruz
   5. Jerome Falcone
   6. Kiana N Jones
   7. Katherine A Forbush
   8. Jonathan Himmelfarb
   9. Benjamin S Freedman
   10. John D Scott

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This paper will be of interest to cell biologists interested in understanding processes that regulate the biogenesis of the primary cilium, and to others interested in ciliopathies (ie disorders of the primary cilium). The authors have identified a novel pathway that controls the generation and length of primary cilia and show that its effects are mediated at least in part through its effects on regulating the cytoskeleton. They suggest that this pathway may also have clinical relevance for autosomal dominant polycystic disease, but the data and rationale underlying this part of the study wold need to be strengthened.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

8. Evolution of irreversible somatic differentiation

   This article has 4 authors:

   1. Yuanxiao Gao
   2. Hye Jin Park
   3. Arne Traulsen
   4. Yuriy Pichugin

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This paper will be of interest to researchers working on a broad range of questions in evolutionary biology, from the evolution of multicellularity to senescence and cancer. With their model, the authors study an often-neglected aspect of cellular differentiation and division of labour. While the model is relatively simple, the premise and the findings are thought-provoking and this study can potentially provide the groundwork for further investigation.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1, Reviewer #2 and Reviewer #3 agreed to share their names with the authors.)

   Reviewed by eLife

9. HOXA9 promotes MYC-mediated leukemogenesis by maintaining gene expression for multiple anti-apoptotic pathways

   This article has 8 authors:

   1. Ryo Miyamoto
   2. Akinori Kanai
   3. Hiroshi Okuda
   4. Yosuke Komata
   5. Satoshi Takahashi
   6. Hirotaka Matsui
   7. Toshiya Inaba
   8. Akihiko Yokoyama

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This manuscript is of potential interest to experimental haematologists studying initiation and maintenance factors in leukaemia. Overall, the study is well designed and the data is clearly presented. However, in some places the analysis lacks depth and technological sophistication, and the novel insights are limited without additional experimentation.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

10. A role for glial fibrillary acidic protein (GFAP)-expressing cells in the regulation of gonadotropin-releasing hormone (GnRH) but not arcuate kisspeptin neuron output in male mice

    This article has 4 authors:

    1. Charlotte Vanacker
    2. R Anthony Defazio
    3. Charlene M Sykes
    4. Suzanne M Moenter

    This article has been curated by 1 group:

    • Curated by eLife

      Evaluation Summary:

      The study by Vanacker et al examines the effect of activating GFAP expressing cells within the POA and ARC on the activity of GnRH and TAC2 neurons as well as LH levels. The authors found that activation of GFAP POA cells activated GnRH neurons and increased circulating LH levels, limited to intact males. Activation of ARC GFAP cells failed to alter TAC2 activity or LH levels. Inhibition of POA GFAP cells or activation of POA GFAP cells in females failed to alter the firing rate of GnRH neurons. The study is largely well done and clearly presented.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

    Reviewed by eLife