eLife

Latest preprint reviews

1. Specialized neurons in the right habenula mediate response to aversive olfactory cues

   This article has 5 authors:

   1. Jung-Hwa Choi
   2. Erik R Duboue
   3. Michelle Macurak
   4. Jean-Michel Chanchu
   5. Marnie E Halpern

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     The three reviewers have appreciated the novelty and originality of the study, but note that improved visualization, quantifications and statistical analyses will be necessary to fully support the conclusions of the manuscript. Without performing these quantifications and statistical tests for all figures as detailed below, the magnitude and significance of reported effects are not clear, nor do they take into account the variability of the measures and the dependence of some of the measures.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 and Reviewer #3 agreed to share their names with the authors.)

   Reviewed by eLife

2. The OpenNeuro resource for sharing of neuroscience data

   This article has 12 authors:

   1. Christopher J Markiewicz
   2. Krzysztof J Gorgolewski
   3. Franklin Feingold
   4. Ross Blair
   5. Yaroslav O Halchenko
   6. Eric Miller
   7. Nell Hardcastle
   8. Joe Wexler
   9. Oscar Esteban
   10. Mathias Goncavles
   11. Anita Jwa
   12. Russell Poldrack

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This manuscript describes the OpenNeuro data sharing platform, which is built upon the Brain Imaging Data Structure (BIDS). More than 500 data sets are stored in BIDS, following the FAIR principles, and integrated with data analysis tools. This is a highly important resource for the neuroimaging community, and the shared data sets have already been used in basic neuroscience and for methods development.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1, Reviewer #2 and Reviewer #3 agreed to share their names with the authors.)

   Reviewed by eLife

3. Metabolic requirement for GOT2 in pancreatic cancer depends on environmental context

   This article has 31 authors:

   1. Samuel A Kerk
   2. Lin Lin
   3. Amy L Myers
   4. Damien J Sutton
   5. Anthony Andren
   6. Peter Sajjakulnukit
   7. Li Zhang
   8. Yaqing Zhang
   9. Jennifer A Jiménez
   10. Barbara S Nelson
   11. Brandon Chen
   12. Anthony Robinson
   13. Galloway Thurston
   14. Samantha B Kemp
   15. Nina G Steele
   16. Megan T Hoffman
   17. Hui-Ju Wen
   18. Daniel Long
   19. Sarah E Ackenhusen
   20. Johanna Ramos
   21. Xiaohua Gao
   22. Zeribe C Nwosu
   23. Stefanie Galban
   24. Christopher J Halbrook
   25. David B Lombard
   26. David R Piwnica-Worms
   27. Haoqiang Ying
   28. Marina Pasca di Magliano
   29. Howard C Crawford
   30. Yatrik M Shah
   31. Costas A Lyssiotis

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This paper investigating specific metabolic dependencies of pancreatic cancer cells growing in vitro and in vivo will be of interest to scientists in the field of cancer metabolism. The data reveal that cancer-associated stromal cells can play an important role supporting the redox state of cancer cells cultured in vitro, but at present the data do not support the conclusion that this mechanism controls the metabolic resilience of cancer cells growing in vivo and alternate hypotheses remain to be addressed.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

4. An Algorithmic Barrier to Neural Circuit Understanding

   This article has 1 author:

   1. Venkatakrishnan Ramaswamy

   Reviewed by eLife

5. A mechano-osmotic feedback couples cell volume to the rate of cell deformation

   This article has 16 authors:

   1. Larisa Venkova
   2. Amit Singh Vishen
   3. Sergio Lembo
   4. Nishit Srivastava
   5. Baptiste Duchamp
   6. Artur Ruppel
   7. Alice Williart
   8. Stéphane Vassilopoulos
   9. Alexandre Deslys
   10. Juan Manuel Garcia Arcos
   11. Alba Diz-Muñoz
   12. Martial Balland
   13. Jean-François Joanny
   14. Damien Cuvelier
   15. Pierre Sens
   16. Matthieu Piel

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     The paper by Venkova et al. is a comprehensive study of mammalian cell volume dynamics during the common cellular process of adhesion and spreading on a flat substrate, osmotic changes, and mechanical confinement. The paper reveals a complex interplay between cell water/ion regulation, cytoskeletal processes, and mechanical deformation of the cell. The topic is important in cell physiology and should be of considerable interest to cell biologists, mechanobiologists and biophysicists.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

6. Adverse childhood experiences and resilience among adult women: A population-based study

   This article has 16 authors:

   1. Hilda Björk Daníelsdóttir
   2. Thor Aspelund
   3. Edda Bjork Thordardottir
   4. Katja Fall
   5. Fang Fang
   6. Gunnar Tómasson
   7. Harpa Rúnarsdóttir
   8. Qian Yang
   9. Karmel W Choi
   10. Beatrice Kennedy
   11. Thorhildur Halldorsdottir
   12. Donghao Lu
   13. Huan Song
   14. Jóhanna Jakobsdóttir
   15. Arna Hauksdóttir
   16. Unnur Anna Valdimarsdóttir

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This is one of the larger studies investigating the impact of adverse experiences during childhood on adult psychological and psychiatric resilience. Using data from an ongoing cohort study on Icelandic women, Daníelsdóttir and colleagues reported that in the face of accumulated adverse childhood events the prevalence of resilience declines, which supports earlier studies suggesting that resilience is not invincibility. Although the data are limited to women within gender binarism and the operationalization of resilience concept could be improved, the quality of the data, (e.g., sample size), justifies the authors' conclusion that the one way to improve resilience in adulthood lies in facilitating the quality of life in childhood. This paper has the potential to make an important contribution to raising awareness of the adverse childhood experiences and their impact on resiliency, which is of interest to those working on childhood adversity and resilience.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

   Reviewed by eLife

7. m6A modifications regulate intestinal immunity and rotavirus infection

   This article has 17 authors:

   1. Anmin Wang
   2. Wanyin Tao
   3. Jiyu Tong
   4. Juanzi Gao
   5. Jinghao Wang
   6. Gaopeng Hou
   7. Chen Qian
   8. Guorong Zhang
   9. Runzhi Li
   10. Decai Wang
   11. Xingxing Ren
   12. Kaiguang Zhang
   13. Siyuan Ding
   14. Richard A Flavell
   15. Huabing Li
   16. Wen Pan
   17. Shu Zhu

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This paper is of interest within the field of virus infection and RNA methylation. The data in the manuscript provide novel information on RNA methylation during rotavirus infection but do not fully support the conclusion because of several technical issues and experimental design.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

8. Dopamine enhances model-free credit assignment through boosting of retrospective model-based inference

   This article has 6 authors:

   1. Lorenz Deserno
   2. Rani Moran
   3. Jochen Michely
   4. Ying Lee
   5. Peter Dayan
   6. Raymond J Dolan

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This paper provides behavioral and modeling evidence for the hypothesis that dopamine is involved in the interaction between distinct model-based and model-free control systems. The issue addressed is timely and clinically relevant, and will be of interest to a broad audience interested in dopamine, learning, choice and planning.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

   Reviewed by eLife

9. ACE2 pathway regulates thermogenesis and energy metabolism

   This article has 11 authors:

   1. Xi Cao
   2. Ting-Ting Shi
   3. Chuan-Hai Zhang
   4. Wan-Zhu Jin
   5. Li-Ni Song
   6. Yi-Chen Zhang
   7. Jing-Yi Liu
   8. Fang-Yuan Yang
   9. Charles N Rotimi
   10. Aimin Xu
   11. Jin-Kui Yang

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     With a series of elegant experiments, the authors have shown that the renin-angiotensin system (RAS) plays a critical role in thermogenesis. Involvement of brown fat and mitochondrial chain open new scenarios that may be helpful to define new target pathways for the treatment of obesity and diabetes.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

10. Judgments of agency are affected by sensory noise without recruiting metacognitive processing

    This article has 3 authors:

    1. Marika Constant
    2. Roy Salomon
    3. Elisa Filevich

    This article has been curated by 1 group:

    • Curated by eLife

      Evaluation Summary:

      This is a well-designed and well-executed study on the computational mechanisms underlying judgements of agency in an action-outcome delay task. The authors report that unlike judgments of confidence, judgments of agency do not recruit metacognitive processes. This difference between agency and confidence could be an important insight, but more needs to be done to address conceptual issues associated with the definition of metacognition, and the specific features of the task and modeling approach used to obtain and interpret the findings.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

    Reviewed by eLife