eLife

Latest preprint reviews

1. Prolonged β-adrenergic stimulation disperses ryanodine receptor clusters in cardiomyocytes and has implications for heart failure

   This article has 15 authors:

   1. Xin Shen
   2. Jonas van den Brink
   3. Anna Bergan-Dahl
   4. Terje R Kolstad
   5. Einar S Norden
   6. Yufeng Hou
   7. Martin Laasmaa
   8. Yuriana Aguilar-Sanchez
   9. Ann P Quick
   10. Emil KS Espe
   11. Ivar Sjaastad
   12. Xander HT Wehrens
   13. Andrew G Edwards
   14. Christian Soeller
   15. William E Louch

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This study applies super-resolution imaging to the distribution of Ca2+ release channels before and after adrenergic stimulation. They make comparisons between healthy and failing cardiomyocytes. The results are specifically applicable to the understanding of contractile function in cardiac failure.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

2. Frequency-specific neural signatures of perceptual content and perceptual stability

   This article has 4 authors:

   1. Richard Hardstone
   2. Matthew W Flounders
   3. Michael Zhu
   4. Biyu J He

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Bistable visual perception offers a unique window to study how perception arises and changes via an interaction between bottom-up and top-down processes. In three Magnetoencephalography (MEG) experiments with advanced neural state space analysis, this study demonstrates that two key aspects of bistable visual perception - perceptual content and perceptual stability - are mediated by slow cortical potential (SCP) and alpha-beta-band neural oscillations, respectively. The findings would be interesting for many fields, such as perception, consciousness, and attention.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

3. Neural representations of naturalistic events are updated as our understanding of the past changes

   This article has 5 authors:

   1. Asieh Zadbood
   2. Samuel Nastase
   3. Janice Chen
   4. Kenneth A Norman
   5. Uri Hasson

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This is a well-designed study that will be of interest to cognitive neuroscientists studying event perception and memory, particularly those interested in naturalistic paradigms. The main contribution is in growing our understanding of how interpretational differences of events are reflected in differences in neural representations of those events. While the presented results are convincing, it remains somewhat unclear what processes drive the observed effects, and thus what the role of the implicated brain regions is in memory updating.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

   Reviewed by eLife

4. An increase of inhibition drives the developmental decorrelation of neural activity

   This article has 3 authors:

   1. Mattia Chini
   2. Thomas Pfeffer
   3. Ileana Hanganu-Opatz

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This manuscript presents a combination of in vivo recording and optogenetic experiments that together with modeling brings a significant message: inhibition is functionally present in the newborn frontal cortex having major effects in EEG dynamics. The work challenges the view on the switch in GABAergic excitation to inhibition and extends phenomenological observations to human infant EEG data.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

   Reviewed by eLife

5. Pre-existing chromosomal polymorphisms in pathogenic E. coli potentiate the evolution of resistance to a last-resort antibiotic

   This article has 8 authors:

   1. Pramod K Jangir
   2. Qiue Yang
   3. Liam P Shaw
   4. Julio Diaz Caballero
   5. Lois Ogunlana
   6. Rachel Wheatley
   7. Timothy Walsh
   8. R Craig MacLean

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This paper combines evolution experiments with genomic analysis of environmental samples to study the evolution of colistin resistance in E. coli. It highlights the importance of pre-existing genomic variations in clinical strains in driving the evolution of antibiotic resistance. The results presented here are relevant for clinical and non-clinical microbiologists studying antibiotic resistance to last-resort drugs like colistin. The design of the research is simple and elegant, and the genomic data analysis connects the in vitro findings to the real world. However, the authors could better align the experimental and clinical data, and better clarify their experimental design choices.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their name with the authors.)

   Reviewed by eLife

6. Vaccination decreases the risk of influenza A virus reassortment but not genetic variation in pigs

   This article has 7 authors:

   1. Chong Li
   2. Marie R Culhane
   3. Declan C Schroeder
   4. Maxim C-J Cheeran
   5. Lucina Galina Pantoja
   6. Micah L Jansen
   7. Montserrat Torremorell

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Vaccines are a major influenza control strategy in swine, but perform sub-optimally and are under-utilized. The manuscript describes a detailed genetic characterization of influenza virus variants in vaccinated versus unvaccinated pigs. The results indicate that viral reassortment, which is an important process yielding new strange of importance to man and animals, may be less common in pigs that have been vaccinated against influenza.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

7. The effect of calcium supplementation in people under 35 years old: A systematic review and meta-analysis of randomized controlled trials

   This article has 10 authors:

   1. Yupeng Liu
   2. Siyu Le
   3. Yi Liu
   4. Huinan Jiang
   5. Binye Ruan
   6. Yufeng Huang
   7. Xuemei Ao
   8. Xudong Shi
   9. Xiaoyi Fu
   10. Shuran Wang

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This is a systematic review by meta-analysis about the effect of calcium supplementation on bone health in people under 35 years old. The authors found that calcium supplementation can significantly improve BMD and BMC in young people. Moreover, a better effect of calcium supplementation was shown in people who are at the plateau of their PBM. A unique feature of this study is that it focused on people at the age before achieving PBM or age at the plateau of PBM, which is different from previous studies that mainly focused on the elderly or children.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

8. A unified view of low complexity regions (LCRs) across species

   This article has 3 authors:

   1. Byron Lee
   2. Nima Jaberi-Lashkari
   3. Eliezer Calo

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This paper describes a new dotplot-based approach for analyzing Low Complexity Regions (LCRs) in proteins. The work is validated against a single protein, compared to existing methods, and applied to the proteomes of several model systems. The work aims to show links between specific LCRs and biological function and subcellular location, and study conservation in LCRs amongst higher species.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

   Reviewed by eLife

9. Selfee, self-supervised features extraction of animal behaviors

   This article has 7 authors:

   1. Yinjun Jia
   2. Shuaishuai Li
   3. Xuan Guo
   4. Bo Lei
   5. Junqiang Hu
   6. Xiao-Hong Xu
   7. Wei Zhang

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Jia et al. present an exciting machine learning framework named "Selfee" for unsupervised and objective analysis of animal behavior that should draw broad interest from researchers studying quantitative animal behavior. However, there are some unresolved issues for establishing credibility of the method that needs to be addressed.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #3 agreed to share their name with the authors.)

   Reviewed by eLife

10. Interplay of surface interaction and magnetic torque in single-cell motion of magnetotactic bacteria in microfluidic confinement

    This article has 7 authors:

    1. Agnese Codutti
    2. Mohammad A Charsooghi
    3. Elisa Cerdá-Doñate
    4. Hubert M Taïeb
    5. Tom Robinson
    6. Damien Faivre
    7. Stefan Klumpp

    This article has been curated by 1 group:

    • Curated by eLife

      Evaluation Summary:

      The manuscript reports results of a combined experimental and numerical investigation of magnetotactic bacteria in strong spatial confinement and under the influence of an external magnetic field. Single cells are trapped in micrometer-sized microfluidic chambers. A variety of trajectories are found, which depend on the chamber size and the strength of the magnetic field. A detailed understanding of swimming in simple controlled confinement is essential to predict the behavior of motile microorganisms in the complex environments of their natural habitat.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

    Reviewed by eLife