eLife

Latest preprint reviews

1. Automated, high-dimensional evaluation of physiological aging and resilience in outbred mice

   This article has 9 authors:

   1. Zhenghao Chen
   2. Anil Raj
   3. GV Prateek
   4. Andrea Di Francesco
   5. Justin Liu
   6. Brice E Keyes
   7. Ganesh Kolumam
   8. Vladimir Jojic
   9. Adam Freund

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Chen et al. develop a comprehensive platform to score aging-dependent changes in mouse physiology and behavior using a multi-dimensional longitudinal phenotyping approach. Their thorough data collection and analysis reveals a diversity of trajectories in aging-related physiological and behavioral changes and helps disentangle biological aging from chronological aging, providing a reference pioneering work for future studies aimed at large-scale aging multi-dimensional phenotyping.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

2. Palatal morphology predicts the paleobiology of early salamanders

   This article has 3 authors:

   1. Jia Jia
   2. Guangzhao Li
   3. Ke-Qin Gao

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This paper is of interest to vertebrate paleontologists and other evolutionary biologists interested in the early evolution of amphibians. Using geometric morphometric analysis, the authors demonstrate that both the shape of the palate and several non-shape variables (particularly associated with vomerine teeth) are ecologically informative in early stem- and basal crown-group salamanders. The phylomorphospace analysis reveals that metamorphosis is significant in the expansion of ecomorphospace of the palate in early salamanders. In overall, the main claims of the manuscript are well supported by the data.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1, Reviewer #2 and Reviewer #3 agreed to share their name with the authors.)

   Reviewed by eLife

3. Unbiased proteomics, histochemistry, and mitochondrial DNA copy number reveal better mitochondrial health in muscle of high-functioning octogenarians

   This article has 10 authors:

   1. Ceereena Ubaida-Mohien
   2. Sally Spendiff
   3. Alexey Lyashkov
   4. Ruin Moaddel
   5. Norah J MacMillan
   6. Marie-Eve Filion
   7. Jose A Morais
   8. Tanja Taivassalo
   9. Luigi Ferrucci
   10. Russell T Hepple

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This study analyzed muscle protein differences between octogenarian master athletes and non-athletes. The data showed that high physical function in octogenarians was associated with the increased mitochondrial proteome, reduced number of muscle fibers impaired by oxphos, and higher mtDNA copy number. The authors propose that this is one of the mechanisms contributing to better performance in master athletes compared with non-athletes, suggesting that mitochondrial health in skeletal muscle is a key feature in inducing improved physical function in the elderly. This article has the potential to generate a significant impact within the field and will be of interest to a broad audience.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their name with the authors.)

   Reviewed by eLife

4. In vivo MRI is sensitive to remyelination in a nonhuman primate model of multiple sclerosis

   This article has 15 authors:

   1. Maxime Donadieu
   2. Nathanael J Lee
   3. María I Gaitán
   4. Seung-Kwon Ha
   5. Nicholas J Luciano
   6. Snehashis Roy
   7. Benjamin Ineichen
   8. Emily C Leibovitch
   9. Cecil C Yen
   10. Dzung L Pham
   11. Afonso C Silva
   12. Mac Johnson
   13. Steve Jacobson
   14. Pascal Sati
   15. Daniel S Reich

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Reich and colleagues have combined MRI imaging and histopathology to study the remyelination of brain lesions in an EAE marmoset model of multiple sclerosis. This work addresses in a non-human primate a missing link in the neuropathology of myelin repair, because in human MS it is virtually impossible to study the lesion dynamics by MRI (in live patients) and demyelination by histology (upon brain autopsy). The present manuscript would be improved by adding further histological evidence of remyelination and clarifying open questions of data acquisition.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

5. Evolution and regulation of microbial secondary metabolism

   This article has 9 authors:

   1. Guillem Santamaria
   2. Chen Liao
   3. Chloe Lindberg
   4. Yanyan Chen
   5. Zhe Wang
   6. Kyu Rhee
   7. Francisco Rodrigues Pinto
   8. Jinyuan Yan
   9. Joao B Xavier

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Santamaria et al. provide interesting insights into the complex regulation used by 31 Pseudomonas aeruginosa clinical strains to minimize the individual costs of cooperative phenotypes based on secondary metabolites. The data analysis is sound and of remarkable depth. Their results challenge the view that there is a tradeoff between primary and secondary metabolism in bacteria and that instead, secondary metabolites may be produced in low-stress conditions when excess carbon is available. However, the relevance of the laboratory growth conditions for these clinical strains requires additional justification.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

6. Mammals adjust diel activity across gradients of urbanization

   This article has 20 authors:

   1. Travis Gallo
   2. Mason Fidino
   3. Brian Gerber
   4. Adam A Ahlers
   5. Julia L Angstmann
   6. Max Amaya
   7. Amy L Concilio
   8. David Drake
   9. Danielle Gay
   10. Elizabeth W Lehrer
   11. Maureen H Murray
   12. Travis J Ryan
   13. Colleen Cassady St Clair
   14. Carmen M Salsbury
   15. Heather A Sander
   16. Theodore Stankowich
   17. Jaque Williamson
   18. J Amy Belaire
   19. Kelly Simon
   20. Seth B Magle

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This study will be of interest to wildlife ecologists and conservation practitioners. The authors took a collaborative approach and collated a large dataset of wildlife camera trap recordings across cities in the USA. The analyses reveal variability in diel activity among species and cities, providing important insights into the effects of urbanization.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their name with the authors.)

   Reviewed by eLife

7. Short senolytic or senostatic interventions rescue progression of radiation-induced frailty and premature ageing in mice

   This article has 13 authors:

   1. Edward Fielder
   2. Tengfei Wan
   3. Ghazaleh Alimohammadiha
   4. Abbas Ishaq
   5. Evon Low
   6. B Melanie Weigand
   7. George Kelly
   8. Craig Parker
   9. Brigid Griffin
   10. Diana Jurk
   11. Viktor I Korolchuk
   12. Thomas von Zglinicki
   13. Satomi Miwa

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This study evaluates the use of senolytics and senostatic agents on post-irradiation-induced frailty. The authors studied the effect of navitoclax, dasatinib/quercitin and metformin on several frailty measures, cognitive function, neuroinflammation, liver function to evaluate the therapeutic efficacy of these treatments. This manuscript has strong translational implications and will be of interest to those working in the aging and cancer therapy fields. This study provides potential new therapeutic options for those developing frailty after radiation treatment.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

8. Windborne migration amplifies insect-mediated pollination services

   This article has 9 authors:

   1. Huiru Jia
   2. Yongqiang Liu
   3. Xiaokang Li
   4. Hui Li
   5. Yunfei Pan
   6. Chaoxing Hu
   7. Xianyong Zhou
   8. Kris AG Wyckhuys
   9. Kongming Wu

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Hoverflies are a group of insects that provide crucial ecosystem services such as pollination and crop protection. Their migratory behavior in western countries is well characterized, but in eastern Asia, the annual summer monsoon provides a 'highway' of favorable winds for the airborne transport of migratory organisms, and the migration of hoverflies in this large region has not been well studied. This study addresses hoverfly migration in this region and its consequences using a variety of suitable methods. The work will be of great interest to insect migration biologists and pollination ecologists.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1, Reviewer #2 and Reviewer #3 agreed to share their name with the authors.)

   Reviewed by eLife

9. Measurements and simulations of microtubule growth imply strong longitudinal interactions and reveal a role for GDP on the elongating end

   This article has 6 authors:

   1. Joseph M Cleary
   2. Tae Kim
   3. Annan SI Cook
   4. Lauren A McCormick
   5. William O Hancock
   6. Luke M Rice

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     The authors use interference reflection microscopy to image a growing microtubule for long intervals at high frame rates, overcoming a limitation of fluorescence. Using careful quantitative analysis, the authors find that the kinetics of dynamic instability are "slow", in contrast to the "rapid kinetics" previously reported. This work provides new mechanistic insight into the mechanism of microtubule growth and is of interest to biologists and physicists interested in cytoskeletal filament dynamics.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

   Reviewed by eLife

10. Hydrodynamic model of fish orientation in a channel flow

    This article has 3 authors:

    1. Maurizio Porfiri
    2. Peng Zhang
    3. Sean D Peterson

    This article has been curated by 1 group:

    • Curated by eLife

      Evaluation Summary:

      The authors address the problem of fish orienting against the mean flow when deprived of visual cues. They study a simple model of swimming dipole and argue that in the absence of flow-sensing feedback, fluid-structure coupling alone is sufficient to generate upstream orienting behavior, above a given flow speed. A comparison with the experimental literature on fish behavior is attempted.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

    Reviewed by eLife