eLife

Latest preprint reviews

1. Machine learning-assisted discovery of growth decision elements by relating bacterial population dynamics to environmental diversity

   This article has 4 authors:

   1. Honoka Aida
   2. Takamasa Hashizume
   3. Kazuha Ashino
   4. Bei-Wen Ying

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Aida et al use a combination of novel experimental measurements and data processing to wrangle the complexity of bacterial growth for different media conditions. This study represents a clear example tackling the complexity of biological systems from the condition sides (~13,000 growth curves were measured) influencing the growth of a well-defined single specie of bacterium and with a reasonable first pass at data processing. The findings are ultimately simple (with essentially 3 conditions accounting all variability in the system) and easily interpretable.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

   Reviewed by eLife

2. Effects of dopamine D2/3 and opioid receptor antagonism on the trade-off between model-based and model-free behaviour in healthy volunteers

   This article has 10 authors:

   1. Nace Mikus
   2. Sebastian Korb
   3. Claudia Massaccesi
   4. Christian Gausterer
   5. Irene Graf
   6. Matthäus Willeit
   7. Christoph Eisenegger
   8. Claus Lamm
   9. Giorgia Silani
   10. Christoph Mathys

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This study provides novel evidence that a dopamine D2 receptor antagonist enhances model-based control of behavior, whereas blocking opioid receptors has no effect on the trade-off between habitual responding and goal-directed planning. These conclusions are based on compelling behavioral and computational modeling data and will be of interest to cognitive neuroscientists and computational psychiatrists.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

3. Infant brain regional cerebral blood flow increases supporting emergence of the default-mode network

   This article has 9 authors:

   1. Qinlin Yu
   2. Minhui Ouyang
   3. John Detre
   4. Huiying Kang
   5. Di Hu
   6. Bo Hong
   7. Fang Fang
   8. Yun Peng
   9. Hao Huang

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     In this paper, the authors find a link between the emergence of functional connectivity (FC) and changes in regional Cerebral Blood Flow (rCBF) in human infancy from birth to 24 months of age, which will be of interest to the increasing field investigating how the establishment of the brain's functional organization is linked to neurodevelopmental and psychiatric conditions. The data quality and complementarity are impressive for infants over this developmental period (0-2 years). Most of the key claims of the manuscript are well supported by the data. However, the relatively sparse sample and cross-sectional nature does limit interpretation.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

4. Nr2f1a maintains atrial nkx2.5 expression to repress pacemaker identity within venous atrial cardiomyocytes of zebrafish

   This article has 5 authors:

   1. Kendall E Martin
   2. Padmapriyadarshini Ravisankar
   3. Manu Beerens
   4. Calum A MacRae
   5. Joshua S Waxman

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This manuscript will be of interest to developmental biologists and pediatric cardiologists. Addressing the role of NR2F transcription factors in the fish heart, it provides novel insight into atrial chamber patterning and the formation of pacemaker cells. High-quality data are presented supporting the novel finding of a requirement of nr2f1a for restricting the production of pacemaker cells. Yet, data are currently not conclusive in claiming transdifferentiation of atrial cells in the mutants.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #3 agreed to share their name with the authors.)

   Reviewed by eLife

5. Early immune markers of clinical, virological, and immunological outcomes in patients with COVID-19: a multi-omics study

   This article has 27 authors:

   1. Zicheng Hu
   2. Kattria van der Ploeg
   3. Saborni Chakraborty
   4. Prabhu S Arunachalam
   5. Diego AM Mori
   6. Karen B Jacobson
   7. Hector Bonilla
   8. Julie Parsonnet
   9. Jason R Andrews
   10. Marisa Holubar
   11. Aruna Subramanian
   12. Chaitan Khosla
   13. Yvonne Maldonado
   14. Haley Hedlin
   15. Lauren de la Parte
   16. Kathleen Press
   17. Maureen Ty
   18. Gene S Tan
   19. Catherine Blish
   20. Saki Takahashi
   21. Isabel Rodriguez-Barraquer
   22. Bryan Greenhouse
   23. Atul J Butte
   24. Upinder Singh
   25. Bali Pulendran
   26. Taia T Wang
   27. Prasanna Jagannathan

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This is an interesting report using computational tools and large amounts of prospective samples from clinical trials to identify different signatures. Using data collected early in the infection in outpatients, the authors aim to identify a set of plasma proteins that can predict a number of outcomes, including disease progression, control of viral shedding, and the onset of antibodies during COVID-19. This study adds to the understanding of the host immune response against COVID-19, as well as the potential of computational tools for the molecular taxonomy of immune responses.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife, ScreenIT

6. Prolonged β-adrenergic stimulation disperses ryanodine receptor clusters in cardiomyocytes and has implications for heart failure

   This article has 15 authors:

   1. Xin Shen
   2. Jonas van den Brink
   3. Anna Bergan-Dahl
   4. Terje R Kolstad
   5. Einar S Norden
   6. Yufeng Hou
   7. Martin Laasmaa
   8. Yuriana Aguilar-Sanchez
   9. Ann P Quick
   10. Emil KS Espe
   11. Ivar Sjaastad
   12. Xander HT Wehrens
   13. Andrew G Edwards
   14. Christian Soeller
   15. William E Louch

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This study applies super-resolution imaging to the distribution of Ca2+ release channels before and after adrenergic stimulation. They make comparisons between healthy and failing cardiomyocytes. The results are specifically applicable to the understanding of contractile function in cardiac failure.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

7. Frequency-specific neural signatures of perceptual content and perceptual stability

   This article has 4 authors:

   1. Richard Hardstone
   2. Matthew W Flounders
   3. Michael Zhu
   4. Biyu J He

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Bistable visual perception offers a unique window to study how perception arises and changes via an interaction between bottom-up and top-down processes. In three Magnetoencephalography (MEG) experiments with advanced neural state space analysis, this study demonstrates that two key aspects of bistable visual perception - perceptual content and perceptual stability - are mediated by slow cortical potential (SCP) and alpha-beta-band neural oscillations, respectively. The findings would be interesting for many fields, such as perception, consciousness, and attention.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

8. Neural representations of naturalistic events are updated as our understanding of the past changes

   This article has 5 authors:

   1. Asieh Zadbood
   2. Samuel Nastase
   3. Janice Chen
   4. Kenneth A Norman
   5. Uri Hasson

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This is a well-designed study that will be of interest to cognitive neuroscientists studying event perception and memory, particularly those interested in naturalistic paradigms. The main contribution is in growing our understanding of how interpretational differences of events are reflected in differences in neural representations of those events. While the presented results are convincing, it remains somewhat unclear what processes drive the observed effects, and thus what the role of the implicated brain regions is in memory updating.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

   Reviewed by eLife

9. An increase of inhibition drives the developmental decorrelation of neural activity

   This article has 3 authors:

   1. Mattia Chini
   2. Thomas Pfeffer
   3. Ileana Hanganu-Opatz

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This manuscript presents a combination of in vivo recording and optogenetic experiments that together with modeling brings a significant message: inhibition is functionally present in the newborn frontal cortex having major effects in EEG dynamics. The work challenges the view on the switch in GABAergic excitation to inhibition and extends phenomenological observations to human infant EEG data.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

   Reviewed by eLife

10. Pre-existing chromosomal polymorphisms in pathogenic E. coli potentiate the evolution of resistance to a last-resort antibiotic

    This article has 8 authors:

    1. Pramod K Jangir
    2. Qiue Yang
    3. Liam P Shaw
    4. Julio Diaz Caballero
    5. Lois Ogunlana
    6. Rachel Wheatley
    7. Timothy Walsh
    8. R Craig MacLean

    This article has been curated by 1 group:

    • Curated by eLife

      Evaluation Summary:

      This paper combines evolution experiments with genomic analysis of environmental samples to study the evolution of colistin resistance in E. coli. It highlights the importance of pre-existing genomic variations in clinical strains in driving the evolution of antibiotic resistance. The results presented here are relevant for clinical and non-clinical microbiologists studying antibiotic resistance to last-resort drugs like colistin. The design of the research is simple and elegant, and the genomic data analysis connects the in vitro findings to the real world. However, the authors could better align the experimental and clinical data, and better clarify their experimental design choices.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their name with the authors.)

    Reviewed by eLife