eLife

Latest preprint reviews

1. Metamorphosis of memory circuits in Drosophila reveals a strategy for evolving a larval brain

   This article has 4 authors:

   1. James W Truman
   2. Jacquelyn Price
   3. Rosa L Miyares
   4. Tzumin Lee

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     The complete metamorphosis of the higher insects is one of the most fascinating and complex processes in nature: The discrepancy in form and function between larvae, pupa, and adult insects is breathtaking, begging the question of how these forms and functions can so seamlessly follow each other. For the highest-order brain centre of the insects, the mushroom body, the authors provide a masterpiece analysis of this process at the cellular level. Given the breadth and depth of the data that the authors present, the current study will serve as a reference for the field of developmental neuroscience for many years to come; this study is eagerly awaited in the field. Perhaps ever more importantly, the insights into the relationship between evolutionary development and individual development at the cellular level might have a profound and lasting conceptual impact on life and natural sciences.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

   Reviewed by eLife

2. Mother cells control daughter cell proliferation in intestinal organoids to minimize proliferation fluctuations

   This article has 9 authors:

   1. Guizela Huelsz-Prince
   2. Rutger Nico Ulbe Kok
   3. Yvonne Goos
   4. Lotte Bruens
   5. Xuan Zheng
   6. Saskia Ellenbroek
   7. Jacco Van Rheenen
   8. Sander Tans
   9. Jeroen S van Zon

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper is a fundamental work in developmental biology that supports its findings with compelling evidence drawn from both theoretical and experiment insights. This work will be of interest to researchers in the fields of developmental and stem cell biology as it provides a potentially general mechanism for the control of a proliferative cell population.

   Reviewed by eLife

3. Pancreatic tumors exhibit myeloid-driven amino acid stress and upregulate arginine biosynthesis

   This article has 18 authors:

   1. Juan J Apiz Saab
   2. Lindsey N Dzierozynski
   3. Patrick B Jonker
   4. Roya AminiTabrizi
   5. Hardik Shah
   6. Rosa Elena Menjivar
   7. Andrew J Scott
   8. Zeribe C Nwosu
   9. Zhou Zhu
   10. Riona N Chen
   11. Moses Oh
   12. Colin Sheehan
   13. Daniel R Wahl
   14. Marina Pasca di Magliano
   15. Costas A Lyssiotis
   16. Kay F Macleod
   17. Christopher R Weber
   18. Alexander Muir

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This study builds on previous observations of arginine depletion in the pancreatic tumor microenvironment, with the goal of developing and using a cell culture medium (TIFM) that better recapitulates nutrient levels in the TME. With this system, the authors identify arginine biosynthesis as an adaptation of pancreatic cancer cells to arginine starvation. This work reinforces a timely message that builds upon the push for optimizing and reformulating cell culture media, so as to improve fidelity, and better recapitulation of physiological/pathophysiological cellular behavior. The latter is in turn critical for translational and therapeutic applications. The work will be of interest to tumor biologists.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their names with the authors.)

   Reviewed by eLife

4. The CIC-ERF co-deletion underlies fusion-independent activation of ETS family member, ETV1, to drive prostate cancer progression

   This article has 10 authors:

   1. Nehal Gupta
   2. Hanbing Song
   3. Wei Wu
   4. Rovingaile K Ponce
   5. Yone K Lin
   6. Ji Won Kim
   7. Eric J Small
   8. Felix Y Feng
   9. Franklin W Huang
   10. Ross A Okimoto

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This paper provides insight into a potentially new genetically defined subset of prostate tumors driven by concurrent loss of two tumor suppressor genes. This study both validates previous findings and provides new data that is compelling overall. With some additional statistical and biochemical evidence to support the conclusions, the work would be of interest to cancer biologists studying molecular mechanisms of prostate cancer.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

   Reviewed by eLife

5. Inhibition of β1-AR/Gαs signaling promotes cardiomyocyte proliferation in juvenile mice through activation of RhoA-YAP axis

   This article has 7 authors:

   1. Masahide Sakabe
   2. Michael Thompson
   3. Nong Chen
   4. Mark Verba
   5. Aishlin Hassan
   6. Richard Lu
   7. Mei Xin

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     The authors identify a novel developmental role for the beta-adrenergic system in the regulation of mammalian cardiac regenerative capacity. Using genetic and pharmacological loss-of-function approaches, the authors identify a link between Yap and β-adrenergic receptor blockade. The conditional genetic loss-of-function studies are a particular strength of the manuscript and provide strong support for the Gas/Yap-dependent nature of the cardiomyocyte proliferative response to beta adrenergic blockade. Given the widespread use of beta blockers in the clinical management of heart failure, the findings are potentially very important. However, further evidence is required to substantiate the induction of bona fide cardiomyocyte proliferation and cardiac regeneration and clarify the associated mechanisms.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

6. Peroxiredoxin 5 regulates osteogenic differentiation through interaction with hnRNPK during bone regeneration

   This article has 13 authors:

   1. Eunjin Cho
   2. Xiangguo Che
   3. Mary Jasmin Ang
   4. Seongmin Cheon
   5. Jinkyung Lee
   6. Kwang Soo Kim
   7. Chang Hoon Lee
   8. Sang-Yeop Lee
   9. Hee-Young Yang
   10. Changjong Moon
   11. Chungoo Park
   12. Je-Yong Choi
   13. Tae-Hoon Lee

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     The research presented in this manuscript is focused on testing the role of peroxiredoxin (Prdx5) and heterogeneous nuclear ribonucleoprotein K (hnRNPK) in bone biology and osteoporosis. Using cell-base and animal models, as well as various experimental methodologies the authors demonstrated that Prdx5 is upregulated during osteogenesis but suppressed during osteoclastogenesis. This novel function Prdx5 was found to be associated with binding and regulation of hnRNPK which controls the expression of genes involved in osteoclastogenesis, such as osteocalcin (Ocn).

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

   Reviewed by eLife

7. Recombinant origin and interspecies transmission of a HERV-K(HML-2)-related primate retrovirus with a novel RNA transport element

   This article has 8 authors:

   1. Zachary H Williams
   2. Alvaro Dafonte Imedio
   3. Lea Gaucherand
   4. Derek C Lee
   5. Salwa Mohd Mostafa
   6. James P Phelan
   7. John M Coffin
   8. Welkin E Johnson

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This work is a bioinformatic analysis of HML-2-like proviruses found in the genomes of Rhesus Macaques, which convincingly argues that an HML-2 provirus underwent an ancient recombination event with a HERV-K (HML-8) related virus. The authors also provide data to suggest that the recombinant retrovirus may have acquired a distinct mechanism for the regulation of expression of spliced and unspliced transcripts. This paper should be of broad interest to virologists as it uses molecular 'fossil-like' evidence contained in the genomes of modern pirates to document the generation of what could be considered a previously undescribed retrovirus species, through recombination.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their name with the authors.)

   Reviewed by eLife

8. Desiccation resistance differences in Drosophila species can be largely explained by variations in cuticular hydrocarbons

   This article has 7 authors:

   1. Zinan Wang
   2. Joseph P Receveur
   3. Jian Pu
   4. Haosu Cong
   5. Cole Richards
   6. Muxuan Liang
   7. Henry Chung

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This paper is an extensive analysis of the underlying basis of desiccation resistance in 50 Drosophila species from diverse habitats. The work suggests that the longer methyl-branched alkanes (mbCHC) of the cuticular hydrocarbons are critical for this resistance. The study, which informs on the evolution of desiccation resistance in flies, is well done, although the main hypothesis is currently only partially supported by coating experiments, which presently lack controls and would be greatly strengthened by "replacement" experiments to add mbCHCs to flies without CHCs. The work is of relevance to evolutionary biologists in general.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

9. Spatiotemporal properties of glutamate input support direction selectivity in the dendrites of retinal starburst amacrine cells

   This article has 10 authors:

   1. Prerna Srivastava
   2. Geoff de Rosenroll
   3. Akihiro Matsumoto
   4. Tracy Michaels
   5. Zachary Turple
   6. Varsha Jain
   7. Santhosh Sethuramanujam
   8. Benjamin L Murphy-Baum
   9. Keisuke Yonehara
   10. Gautam Bhagwan Awatramani

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This is an important paper that addresses a key mechanism that underlies the canonical computation of direction selectivity in the retina. By using fluorescence imaging of glutamate release from excitatory interneurons combined with a computational model of dendritic integration, the authors make a convincing case that the kinetics of glutamate release contributes to the direction-selectivity of individual neural processes in retinal neurons. This work will appeal to visual neuroscientists as well as cellular physiologists interested in dendritic computations.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

   Reviewed by eLife

10. Interplay between PML NBs and HIRA for H3.3 dynamics following type I interferon stimulus

    This article has 10 authors:

    1. Constance Kleijwegt
    2. Florent Bressac
    3. Coline Seurre
    4. Wilhelm Bouchereau
    5. Camille Cohen
    6. Pascale Texier
    7. Thomas Simonet
    8. Laurent Schaeffer
    9. Patrick Lomonte
    10. Armelle Corpet

    This article has been curated by 1 group:

    • Curated by eLife

      Evaluation Summary:

      In this manuscript, of interest to the fields of animal immunity and epigenetics, the authors investigate the crosstalk between PML Nuclear Bodies and HIRA, a member of the H3.3 histone chaperone complex, during inflammatory stress. This study raises interesting perspectives on how availability of HIRA could be regulated by PML Nuclear Bodies for histone deposition onto interferon-stimulated genes, which in turn, could be relevant for immune-response mediated gene regulation.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

    Reviewed by eLife