eLife

Latest preprint reviews

1. Position representations of moving objects align with real-time position in the early visual response

   This article has 6 authors:

   1. Philippa Anne Johnson
   2. Tessel Blom
   3. Simon van Gaal
   4. Daniel Feuerriegel
   5. Stefan Bode
   6. Hinze Hogendoorn

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper is of potential interest to any neuroscientist, given it asks how the brain compensates for its own neural transmission delays. This is a problem that runs across neuroscientific disciplines. The authors use a clever and simple design where they study this question in the context of decoding from EEG signals during visual motion processing. They robustly show evidence that the brain can indeed compensate for these delays, although all compensation appears to be afforded by early processing. The manuscript is well-written but can be strengthened by outlining its significance for the broader community as well as some further analyses.

   Reviewed by eLife

2. ARPC5 isoforms and their regulation by calcium-calmodulin-N-WASP drive distinct Arp2/3-dependent actin remodeling events in CD4 T cells

   This article has 6 authors:

   1. Lopamudra Sadhu
   2. Nikolaos Tsopoulidis
   3. Md Hasanuzzaman
   4. Vibor Laketa
   5. Michael Way
   6. Oliver T Fackler

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This fundamental study demonstrates that the two isoforms of the ARPC5 subunit (ARPC5 and ARPC5L) of the Arp2/3 complex have specific functions in regulating cytoplasmic and nuclear actin filament assembly in response to DNA replication stress and T cell receptor signaling in T lymphocytes. The data presented in the manuscript are convincing and of good technical quality, and the study provides interesting new insights into specific cellular roles of different Arp2/3 isoforms in T lymphocytes.

   Reviewed by eLife

3. Peripheral and central employment of acid-sensing ion channels during early bilaterian evolution

   This article has 5 authors:

   1. Josep Martí-Solans
   2. Aina Børve
   3. Paul Bump
   4. Andreas Hejnol
   5. Timothy Lynagh

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This work examines the evolutionary origins of acid-sensing ion channels (ASICs), a class of pH-sensing receptors expressed throughout the brain and body. By combining analysis of sequences, functional measurements, and measures of tissue distribution, the authors provide solid evidence that ASICs existed far earlier than previously believed. The present data indicate that ASICs emerged after the split between bilaterians (organisms with two-fold symmetry) and Cnidaria (jellyfish, anemones, corals, etc.), approximately 680 million years ago. This evolutionary and functional analysis of ASIC channels across bilaterian lineages provides relevant information about the evolution of nervous and sensory systems.

   Reviewed by eLife

4. T cell receptor convergence is an indicator of antigen-specific T cell response in cancer immunotherapies

   This article has 2 authors:

   1. Mingyao Pan
   2. Bo Li

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript reports an association between TCR convergence and involvement in an antigen-specific response. TCR convergence is assessed as a potential biomarker of response to immune checkpoint blockade (ICB). From jointly analyzing TCR-seq data, single-cell RNA-seq data, and antigen-specific TCR information, the authors provided evidence that convergence is a potential indicator for ongoing T cell antigen-specific response. Overall, the analyses are sound the manuscript is well-written, and the study provides the first evidence that TCRseq alone could be used to predict clinical outcomes.

   Reviewed by eLife

5. Novel pathogen introduction triggers rapid evolution in animal social movement strategies

   This article has 5 authors:

   1. Pratik Rajan Gupte
   2. Gregory F Albery
   3. Jakob Gismann
   4. Amy Sweeny
   5. Franz J Weissing

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The authors present a rich investigation of the evolution of social-movement rules in animal societies under pathogen pressure. The study should be of interest to a broad readership.

   Reviewed by eLife

6. VPS9D1-AS1 overexpression amplifies intratumoral TGF-β signaling and promotes tumor cell escape from CD8+ T cell killing in colorectal cancer

   This article has 8 authors:

   1. Lei Yang
   2. Xichen Dong
   3. Zheng Liu
   4. Jinjing Tan
   5. Xiaoxi Huang
   6. Tao Wen
   7. Hao Qu
   8. Zhenjun Wang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This research focuses on the role of a long noncoding RNA VPS9D1-AS1(VPS) in colorectal cancer (CRC) immune evasion and provides evidence on how it is responsible for escape from cytotoxic T cells killing via amplifying intra-tumoral TGF-β signaling. The findings are of considerable translational significance since VPS9D1-AS1 was validated targetable in this work, and it is of broad interest to readers in cancer biology and immunotherapy.

   Reviewed by eLife

7. Temporal derivative computation in the dorsal raphe network revealed by an experimentally driven augmented integrate-and-fire modeling framework

   This article has 10 authors:

   1. Emerson F Harkin
   2. Michael B Lynn
   3. Alexandre Payeur
   4. Jean-François Boucher
   5. Léa Caya-Bissonnette
   6. Dominic Cyr
   7. Chloe Stewart
   8. André Longtin
   9. Richard Naud
   10. Jean-Claude Béïque

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Harkin and colleagues explore functional properties of dorsal raphe serotonin neurons using the approach called a generalized integrate-and-fire [aGIF] model, which incorporates a relatively small number of salient biophysical properties of a specific neuron type, and whose parameters are optimized based on voltage dynamics obtained experimentally. The authors make an interesting finding that after-hyperpolarization and A-type potassium currents, in combination with heterogeneous feedforward inhibition from local GABA neurons, give rise to a derivative-like input-output relationship in serotonin neurons.

   Reviewed by eLife

8. ATP6AP2-to-MMP14, a key pathway for osteoblast to osteocyte transition

   This article has 7 authors:

   1. Lei Xiong
   2. Hao-Han Guo
   3. Jin-Xiu Pan
   4. Xiao Ren
   5. Daehoon Lee
   6. Lin Mei
   7. Wen-Cheng Xiong

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript is of interest to readers in the field of bone biology. It identifies a novel role for the vacuolar ATPase accessory protein ATP6AP2 within the osteoblast lineage and shows that loss of ATP6AP2 in the mature osteoblast results in disorganized bone formation. A similar, but milder, bone disorganization phenotype is also observed when this gene is knocked out in osteocytes. The authors show that this bone phenotype is partially rescued via restoration of MMP14 action.

   Reviewed by eLife

9. Phenotyping single-cell motility in microfluidic confinement

   This article has 7 authors:

   1. Samuel A Bentley
   2. Hannah Laeverenz-Schlogelhofer
   3. Vasileios Anagnostidis
   4. Jan Cammann
   5. Marco G Mazza
   6. Fabrice Gielen
   7. Kirsty Y Wan

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper reports on the development of an impressive microfluidic platform for the study of motility, and motility transitions, exhibited by single algal cells in circular confinement. Building on previous work that showed a three-state motility repertoire for certain green algae, the present work uses extremely long time series and a variety of physical perturbations to show how those dynamics can be altered by environmental conditions. The work will be of interest to a wide range of scientists studying motility and nonequilibrium dynamics, but its impact would be improved by a more insightful analysis of the voluminous data, with connections to physical principles.

   Reviewed by eLife

10. The genetic risk of gestational diabetes in South Asian women

    This article has 11 authors:

    1. Amel Lamri
    2. Jayneel Limbachia
    3. Karleen M Schulze
    4. Dipika Desai
    5. Brian Kelly
    6. Russell J de Souza
    7. Guillaume Paré
    8. Deborah A Lawlor
    9. John Wright
    10. Sonia S Anand
    11. On behalf of for the Born in Bradford and START investigators

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This paper asks whether a risk score integrating the impact of common genetic variants across the genome (polygenic risk score) on Type II Diabetes is also to any degree predictive of diabetes in pregnancy (Gestational diabetes or GDM).The study population comprises women of South Asian ancestry, who are particularly susceptible to GDM. Strong evidence is presented in favour of the hypothesis of the hypothesis in two sizeable cohorts, one from Canada and the other from the UK. The paper will be useful to those studying women's health in pregnancy, and in particular GDM, which is associated with a number of adverse pregnancy outcomes.

    Reviewed by eLife