eLife

Latest preprint reviews

1. The zebrafish mutant dreammist implicates sodium homeostasis in sleep regulation

   This article has 9 authors:

   1. Ida L Barlow
   2. Eirinn Mackay
   3. Emily Wheater
   4. Aimee Goel
   5. Sumi Lim
   6. Steve Zimmerman
   7. Ian Woods
   8. David A Prober
   9. Jason Rihel

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment:

     This study offers new fundamental information on a role for the sodium/potassium pump in sleep regulation. Elegant methods were used to provide compelling evidence supporting the claim. The work will be of interest to sleep researchers in zebrafish as well as in other species for future investigation.

   Reviewed by eLife

2. Age-related differences in the functional topography of the locus coeruleus and their implications for cognitive and affective functions

   This article has 13 authors:

   1. Dániel Veréb
   2. Mite Mijalkov
   3. Anna Canal-Garcia
   4. Yu-Wei Chang
   5. Emiliano Gomez-Ruiz
   6. Blanca Zufiria Gerboles
   7. Miia Kivipelto
   8. Per Svenningsson
   9. Henrik Zetterberg
   10. Giovanni Volpe
   11. Matthew Betts
   12. Heidi IL Jacobs
   13. Joana B Pereira

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study provides fundamental imaging evidence from two independent functional imaging datasets, for a rostral-caudal gradient of locus coeruleus connectivity, which changes across the lifespan. The gradient approach is well-established and convincing results were obtained and validated using large 3T and 7T fMRI datasets. This work will be of interest to clinical and cognitive neuroscientists.

   Reviewed by eLife

3. We couldn't get details of this article at this time:
   10.1101/2023.02.13.528292

4. Imaging microglia surveillance during sleep-wake cycles in freely behaving mice

   This article has 12 authors:

   1. Xiaochun Gu
   2. Zhong Zhao
   3. Xueli Chen
   4. Lifeng Zhang
   5. Huaqiang Fang
   6. Ting Zhao
   7. Shenghong Ju
   8. Weizheng Gao
   9. Xiaoyu Qian
   10. Xianhua Wang
   11. Jue Zhang
   12. Heping Cheng

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study uses cutting-edge miniature two-photon microscopy to follow the structural dynamics of microglia in the somatosensory cortex of freely-moving mice across the sleep/wake cycle. Solid evidence revealed the brain-state-dependent regulation of microglial activity, highlighting alterations in microglial morphology during REM and NREM sleep phases compared to wakefulness. Furthermore, this study provides evidence for a critical role of norepinephrine from the locus coeruleus as a modulator of microglial morphology through the β2-adrenergic receptor (b2AR). Overall, the article is an impressive technical feat to bridge a crucial gap in understanding sleep state-induced dynamics of microglia and its modulation by norepinephrine signaling.

   Reviewed by eLife

5. Vitamin D induces SIRT1 activation through K610 deacetylation in colon cancer

   This article has 11 authors:

   1. José Manuel García-Martínez
   2. Ana Chocarro-Calvo
   3. Javier Martínez-Useros
   4. María Jesús Fernández-Aceñero
   5. M Carmen Fiuza
   6. José Cáceres-Rentero
   7. Antonio De la Vieja
   8. Antonio Barbáchano
   9. Alberto Muñoz
   10. María Jesús Larriba
   11. Custodia García-Jiménez

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study demonstrates that vitamin D-bound VDR increased the expression of SIRT1 and that vitamin D-bound VDR interacts with SIRT1 to cause auto-deacetylation on Lys610 and activation of SIRT1 catalytic activity. This is an important finding that is relevant to the actions of VDR on colorectal cancer. The data presented to support the presented conclusion are convincing.

   Reviewed by eLife

6. A positive feedback loop between ZEB2 and ACSL4 regulates lipid metabolism to promote breast cancer metastasis

   This article has 8 authors:

   1. Jiamin Lin
   2. Pingping Zhang
   3. Wei Liu
   4. Guorong Liu
   5. Juan Zhang
   6. Min Yan
   7. Yuyou Duan
   8. Na Yang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study provides a valuable finding on the mechanistic connections between epithelial-mesenchymal transition (EMT) and lipid metabolism. The authors identified the ZEB2/ACSL4 axis as a newly discovered metastatic metabolic pathway that promotes both lipogenesis and fatty acid oxidation. The evidence supporting the claims of the authors is solid. The work will be of interest to medical biologists working on cancer.

   Reviewed by eLife

7. We couldn't get details of this article at this time:
   10.1101/2022.01.31.478462

8. Improved isolation of extracellular vesicles by removal of both free proteins and lipoproteins

   This article has 10 authors:

   1. Dmitry Ter-Ovanesyan
   2. Tal Gilboa
   3. Bogdan Budnik
   4. Adele Nikitina
   5. Sara Whiteman
   6. Roey Lazarovits
   7. Wendy Trieu
   8. David Kalish
   9. George M Church
   10. David R Walt

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study will be of interest and valuable to scientists of many different subareas in the study of eukaryotic extracellular vesicles. The authors' efforts to improve the way we analyze EVs are highly appreciated and their results are convincing: they not only used appropriate and validated methodologies in line with current state-of-the-art but also presented alternatives to improve these approaches.

   Reviewed by eLife

9. The ER folding sensor UGGT1 acts on TAPBPR-chaperoned peptide-free MHC I

   This article has 6 authors:

   1. Lina Sagert
   2. Christian Winter
   3. Ina Ruppert
   4. Maximilian Zehetmaier
   5. Christoph Thomas
   6. Robert Tampé

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study reports a complete in vitro system where different steps and direct interactions between different components of MHCI maturation can be monitored, hence leading to a better mechanistic understanding of MHC I maturation. The evidence supporting the findings is currently incomplete and would benefit from clarification of some key issues. This work will be of interest to immunologists and biochemists.

   Reviewed by eLife

10. Control of telomere length in yeast by SUMOylated PCNA and the Elg1 PCNA unloader

    This article has 3 authors:

    1. Pragyan Singh
    2. Inbal Gazy
    3. Martin Kupiec

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This important study aims to discover the mechanisms governing the switch between conventional DNA replication and the specialized mechanism of telomere end replication. Solid genetic and biochemical assays suggest an interplay between sumoylated PCNA and chromosome terminal capping proteins. The questions addressed have implications for several fields, such as genome stability.

    Reviewed by eLife