eLife

Latest preprint reviews

1. Dating the origin and spread of specialization on human hosts in Aedes aegypti mosquitoes

   This article has 10 authors:

   1. Noah H Rose
   2. Athanase Badolo
   3. Massamba Sylla
   4. Jewelna Akorli
   5. Sampson Otoo
   6. Andrea Gloria-Soria
   7. Jeffrey R Powell
   8. Bradley J White
   9. Jacob E Crawford
   10. Carolyn S McBride

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This fundamental study by Rose and colleagues addresses key challenges in demographic inference in non-model systems with an innovative approach to model parameter calibration based on known historical events. Using this approach, they convincingly show that human specialization in Ae. aegypti mosquitoes likely evolved due to a past climate event around 5,000 years ago, and that recent rapid urbanization has continued to fuel its spread in West Africa in the past 20-40 years. This work will be of broad interest to population geneticists working on demographic inference, and to mosquito biologists working on the monitoring and control of this important vector species.

   Reviewed by eLife

2. Insights into cargo sorting by SNX32 and its role in neurite outgrowth

   This article has 8 authors:

   1. Jini Sugatha
   2. Amulya Priya
   3. Prateek Raj
   4. Ebsy Jaimon
   5. Uma Swaminathan
   6. Anju Jose
   7. Thomas John Pucadyil
   8. Sunando Datta

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript presents a series of important findings about the roles of the BAR-domain containing protein SNX32 in endosomal cargo sorting and in neurite outgrowth. The authors provide convincing evidence for their claims, which will be of interest for those working not only in membrane trafficking but also for cell biologists in general with interest in neurobiology.

   Reviewed by eLife

3. The photosystem I supercomplex from a primordial green alga Ostreococcus tauri harbors three light-harvesting complex trimers

   This article has 11 authors:

   1. Asako Ishii
   2. Jianyu Shan
   3. Xin Sheng
   4. Eunchul Kim
   5. Akimasa Watanabe
   6. Makio Yokono
   7. Chiyo Noda
   8. Chihong Song
   9. Kazuyoshi Murata
   10. Zhenfeng Liu
   11. Jun Minagawa

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The fundamental work represents an important contribution to our understanding of the diversity of photosynthetic mechanisms across the branches of phototrophic life, with the first high-resolution structure (2.9 Å) of a photosynthetic complex from a primitive green alga. This is a valuable resource for understanding function and evolution of light-harvesting antennas. The evidence is convincing in suggesting that the mechanism found here is distinct from the classical antenna state transitions seen in other organisms studied thus far.

   Reviewed by eLife

4. Model-based whole-brain perturbational landscape of neurodegenerative diseases

   This article has 12 authors:

   1. Yonatan Sanz Perl
   2. Sol Fittipaldi
   3. Cecilia Gonzalez Campo
   4. Sebastián Moguilner
   5. Josephine Cruzat
   6. Matias E Fraile-Vazquez
   7. Rubén Herzog
   8. Morten L Kringelbach
   9. Gustavo Deco
   10. Pavel Prado
   11. Agustin Ibanez
   12. Enzo Tagliazucchi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Sanz Perl and colleagues provide important insights regarding the application of computational brain models from neurodegenerative diseases to evaluate brain stimulation protocols in silico. Solid evidence is provided for the disease-specificity of the framework, however, the real-world impact of such stimulation protocols to alleviate psychiatric and neurological symptoms remains to be evaluated.

   Reviewed by eLife

5. Molecular and spatial profiling of the paraventricular nucleus of the thalamus

   This article has 7 authors:

   1. Claire Gao
   2. Chiraag A Gohel
   3. Yan Leng
   4. Jun Ma
   5. David Goldman
   6. Ariel J Levine
   7. Mario A Penzo

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study uses single cell sequencing to characterize transcriptional profiles of cells in a brain region called the PVT that plays many roles in brain function. The authors combine these data with dataset of neuronal connectivity and conclude there are transcriptomically distinguishable populations of neurons in the PVT with different function. These data deepen our understanding of an important brain region.

   Reviewed by eLife

6. Quantitative trait and transcriptome analysis of genetic complexity underpinning cardiac interatrial septation in mice using an advanced intercross line

   This article has 15 authors:

   1. Mahdi Moradi Marjaneh
   2. Edwin P Kirk
   3. Ralph Patrick
   4. Dimuthu Alankarage
   5. David T Humphreys
   6. Gonzalo Del Monte-Nieto
   7. Paola Cornejo-Paramo
   8. Vaibhao Janbandhu
   9. Tram B Doan
   10. Sally L Dunwoodie
   11. Emily S Wong
   12. Chris Moran
   13. Ian CA Martin
   14. Peter C Thomson
   15. Richard P Harvey

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study of mouse genetic variation in atrial septum formation, a trait correlated with the patent foramen ovale (PFO) cardiac defect, provides convincing evidence for 37 quantitative trait loci (QTL) affecting this trait, combining genetic mapping with transcriptome analysis to zero in on relevant pathways and candidate genes within the QTL, and validating the role of one gene in tissue culture. The paper provides an important resource for hypothesis generation and future studies, which could lead to novel diagnostic or therapeutic approaches that target atrial septal defects in common congenital heart disease.

   Reviewed by eLife

7. Parahippocampal neurons encode task-relevant information for goal-directed navigation

   This article has 2 authors:

   1. Alexander Gonzalez
   2. Lisa M Giocomo

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this study, neurons were recorded and combined across the parahippocampal area while rats performed a memory-guided spatial navigation task. Sophisticated analytical tools were used to provide convincing evidence that neuronal populations in these areas show behavior-related changes that might indicate the encoding of errors by the system. The valuable results suggest that rate remapping is a likely mechanism to support changes in representations that support memory-guided behavior in these regions, most interestingly in neurons that code head direction.

   Reviewed by eLife

8. Lipid hydroperoxides promote sarcopenia through carbonyl stress

   This article has 20 authors:

   1. Hiroaki Eshima
   2. Justin L Shahtout
   3. Piyarat Siripoksup
   4. MacKenzie J Pearson
   5. Ziad S Mahmassani
   6. Patrick J Ferrara
   7. Alexis W Lyons
   8. John Alan Maschek
   9. Alek D Peterlin
   10. Anthony RP Verkerke
   11. Jordan M Johnson
   12. Anahy Salcedo
   13. Jonathan J Petrocelli
   14. Edwin R Miranda
   15. Ethan J Anderson
   16. Sihem Boudina
   17. Qitao Ran
   18. James E Cox
   19. Micah J Drummond
   20. Katsuhiko Funai

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important paper advances our understanding of the role of lipid peroxidation in loss of muscle mass and force-generating capacity during aging and hind-limb suspension. The evidence is in general solid, drawing from experiments in vivo and cell culture using multiple types of manipulations of the formation of lipid peroxides although some weaknesses were identified. The results should be of interest to those who study the molecular basis for sarcopenia and disuse atrophy of skeletal muscle.

   Reviewed by eLife

9. Histone deacetylase 1 maintains lineage integrity through histone acetylome refinement during early embryogenesis

   This article has 6 authors:

   1. Jeff Jiajing Zhou
   2. Jin Sun Cho
   3. Han Han
   4. Ira L Blitz
   5. Wenqi Wang
   6. Ken WY Cho

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this manuscript, the authors investigate the role of histone deacetylases in the spatial epigenetic control of zygotic gene expression in early gastrulation. They discover HDAC1 binding is maternally-controlled and that inhibition of histone acetylation blocks gastrulation and disrupts cell lineage integrity, tied to both positive and negative regulatory effects on gene transcription in space and time. The study contributes to a growing body of evidence that highlights a central role of histone acetylation-deacetylation dynamics in epigenetic regulation of gene expression and cell fating in early tissue patterning of the embryo.

   Reviewed by eLife

10. Ion permeation pathway within the internal pore of P2X receptor channels

    This article has 4 authors:

    1. Stephanie W Tam
    2. Kate Huffer
    3. Mufeng Li
    4. Kenton J Swartz

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment:

      This study provides valuable insight into the molecular mechanism of ion selectivity in the broader family of ATP-gated P2X receptors. The experimental data are of high quality, the evidence supporting the conclusions is convincing, and the work will be of broad interest to biophysicists working on ion channel selectivity.

    Reviewed by eLife