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  1. A role for JAK2 in mediating cell surface GHR-PRLR interaction

    This article has 7 authors:
    1. Chen Chen
    2. Jing Jiang
    3. Tejeshwar C Rao
    4. Ying Liu
    5. Tatiana T Marquez Lago
    6. Stuart J Frank
    7. André Leier
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This is an important study that characterizes a surprising interaction between two different cytokine/hormone receptors using nanoscale resolution (dSTORM) microscopy. The study provides solid evidence that the interaction is ligand-dependent, and is mediated by the receptor-associated intracellular signalling molecule JAK2. While at present limited to growth hormone and prolactin receptors in a limited number of cell lines, there are potentially broad implications for cytokine signalling, as such JAK2-mediated interactions could occur between a range of different cytokines. Moreover, the specific hormone interactions shown in the manuscript may have significant implications for understanding how these hormones can have differential effects in breast cancer, under different conditions.

    Reviewed by eLife

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