eLife

Latest preprint reviews

1. Revealing unexpected complex encoding but simple decoding mechanisms in motor cortex via separating behaviorally relevant neural signals

   This article has 4 authors:

   1. Yangang Li
   2. Xinyun Zhu
   3. Yu Qi
   4. Yueming Wang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents a useful method for the extraction of behaviour-related activity from neural population recordings based on a specific deep learning architecture, a variational autoencoder. Although the authors performed thorough benchmarking of their method in the context of decoding behavioural variables, the evidence supporting claims about encoding is incomplete as the results may stem, in part, from the properties of the method itself.

   Reviewed by eLife

2. Running modulates primate and rodent visual cortex differently

   This article has 7 authors:

   1. John P Liska
   2. Declan P Rowley
   3. Trevor Thai Kim Nguyen
   4. Jens-Oliver Muthmann
   5. Daniel A Butts
   6. Jacob Yates
   7. Alexander C Huk

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important work advances our understanding of the differences in locomotion-induced modulation in primate and rodent visual cortexes and underlines the significant contribution cross-species comparisons make to investigating brain function. The evidence in support of these differences across species is convincing. This work will be of broad interest to neuroscientists.

   Reviewed by eLife

3. Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states

   This article has 6 authors:

   1. David Yin-wei Lin
   2. Lauren E Kueffer
   3. Puneet Juneja
   4. Thomas E Wales
   5. John R Engen
   6. Amy H Andreotti

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     BTK, a TEC-family tyrosine kinase activated by the B-cell antigen receptor, contains a variety of regulatory domains and it is subject to complex regulation by membrane phospholipids, protein ligands, phosphorylation, and dimerization. This study presents convincing evidence, utilizing various biophysical techniques, to support a model for BTK activation that will be valuable for the field. Overall, the study enhances the understanding of BTK's activation mechanism, autoinhibition, and allosteric control, challenging previous assumptions about BTK.

   Reviewed by eLife

4. Absence of electron-transfer-associated changes in the time-dependent X-ray free-electron laser structures of the photosynthetic reaction center

   This article has 4 authors:

   1. Gai Nishikawa
   2. Yu Sugo
   3. Keisuke Saito
   4. Hiroshi Ishikita

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The manuscript describes valuable theoretical calculations focusing on the structural changes in the photosynthetic reaction center postulated by others based on time-resolved crystallography using X-ray free-electron laser (XFEL) (Dods et al., Nature, 2021). The authors provide solid arguments that calculated changes in redox potential Em and deformations using the XEFL structures may reflect experimental errors rather than real structural changes.

   Reviewed by eLife

5. miR-252 targeting temperature receptor CcTRPM to mediate the transition from summer-form to winter-form of Cacopsylla chinensis

   This article has 7 authors:

   1. Songdou Zhang
   2. Jianying Li
   3. Dongyue Zhang
   4. Zhixian Zhang
   5. Shili Meng
   6. Zhen Li
   7. Xiaoxia Liu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is a valuable study of the molecular basis of summer-to-winter transition in the pear psyllid pest, Cacopsylla chinensis (hemiptera). The molecular and organismal experiments using current methodologies to evaluate the cold responsiveness of the target proteins are mostly convincing, but the structural and phylogenetic analyses remain inconclusive. The results of this study will be of interest to entomologists.

   Reviewed by eLife

6. Distinct states of nucleolar stress induced by anticancer drugs

   This article has 7 authors:

   1. Tamara A Potapova
   2. Jay R Unruh
   3. Juliana Conkright-Fincham
   4. Charles AS Banks
   5. Laurence Florens
   6. David Alan Schneider
   7. Jennifer L Gerton

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study and associated data is compelling, novel, important, and well-carried out. The study demonstrates a novel finding that different chemotherapeutic agents can induce nucleolar stress, which manifests with varying cellular and molecular characteristics. The study also proposes a mechanism for how a novel type of nucleolar stress driven by CDK inhibitors may be regulated. The study sheds light on the importance of nucleolar stress in defining the on-target and off-target effects of chemotherapy in normal and cancer cells.

   Reviewed by eLife

7. Human skeletal muscle organoids model fetal myogenesis and sustain uncommitted PAX7 myogenic progenitors

   This article has 22 authors:

   1. Lampros Mavrommatis
   2. Hyun-Woo Jeong
   3. Urs Kindler
   4. Gemma Gomez-Giro
   5. Marie-Cecile Kienitz
   6. Martin Stehling
   7. Olympia E Psathaki
   8. Dagmar Zeuschner
   9. M Gabriele Bixel
   10. Dong Han
   11. Gabriela Morosan-Puopolo
   12. Daniela Gerovska
   13. Ji Hun Yang
   14. Jeong Beom Kim
   15. Marcos J Arauzo-Bravo
   16. Jens C Schwamborn
   17. Stephan A Hahn
   18. Ralf H Adams
   19. Hans R Schöler
   20. Matthias Vorgerd
   21. Beate Brand-Saberi
   22. Holm Zaehres

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The authors develop a cell culture system for studies of muscle tissue development and homeostasis. They convincingly validate a novel 3D cell model. Their thorough molecular and functional characterization will make this useful for future workers in the field.

   Reviewed by eLife

8. Vacuolar H+-ATPase determines daughter cell fates through asymmetric segregation of the nucleosome remodeling and deacetylase complex

   This article has 10 authors:

   1. Zhongyun Xie
   2. Yongping Chai
   3. Zhiwen Zhu
   4. Zijie Shen
   5. Zhengyang Guo
   6. Zhiguang Zhao
   7. Long Xiao
   8. Zhuo Du
   9. Guangshuo Ou
   10. Wei Li

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The authors make the intriguing proposal that the NuRD complex in C. elegans, which has been linked to regulation of the cell death protein EGL-1 before, becomes asymmetrically distributed after cell division and that this asymmetry relies on V-ATPase activity. Whereas some disagreement remained between the reviewers' and the authors' interpretation, the final version incorporated alternative possibilities in the text, and with careful interpretation, the current manuscript's model is supported by solid data, and represents a valuable contribution to the field.

   Reviewed by eLife

9. Landscape drives zoonotic malaria prevalence in non-human primates

   This article has 13 authors:

   1. Emilia Johnson
   2. Reuben Sunil Kumar Sharma
   3. Pablo Ruiz Cuenca
   4. Isabel Byrne
   5. Milena Salgado-Lynn
   6. Zarith Suraya Shahar
   7. Lee Col Lin
   8. Norhadila Zulkifli
   9. Nor Dilaila Mohd Saidi
   10. Chris Drakeley
   11. Jason Matthiopoulos
   12. Luca Nelli
   13. Kimberly Fornace

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This useful study presents findings regarding the impact of forest cover and fragmentation on the prevalence of malaria in non-human primates. The evidence supporting the claims of the authors is solid.

   Reviewed by eLife

10. Metabolic memory of Δ9-tetrahydrocannabinol exposure in pluripotent stem cells and primordial germ cells-like cells

    This article has 7 authors:

    1. Roxane Verdikt
    2. Abigail A Armstrong
    3. Jenny Cheng
    4. Young Sun Hwang
    5. Amander T Clark
    6. Xia Yang
    7. Patrick Allard

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      The study presents valuable findings demonstrating that physiologically relevant concentrations delta-9-tetrahydrocannabinol, which is found in cannabis, have metabolic effects on early mouse embryonic cell types. The evidence supporting the claims is convincing. The work will be of interest to researchers in stem cell and epigenetics fields.

    Reviewed by eLife