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10. A wave of minor de novo DNA methylation initiates in mouse 8-cell embryos and co-regulates imprinted X- chromosome inactivation with H3K27me3

    This article has 13 authors:

    1. Yuan Yue
    2. Wei Fu
    3. Qianying Yang
    4. Chao Zhang
    5. Wenjuan Wang
    6. Meiqiang Chu
    7. Qingji Lyu
    8. Yawen Tang
    9. Jian Cui
    10. Xiaodong Wang
    11. Zhenni Zhang
    12. Jianhui Tian
    13. Lei An

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      The authors present an valuable and intriguing observation challenging current views on DNA methylation dynamics, revealing earlier-than-expected de novo methylation with significant implications for gene regulation in early embryonic development. However, the study's significance is difficult to ascertain due to incomplete evidence supporting the conclusions. Moreover, the observed changes in DNA methylation across promoter regions is modest, leaving its relevance open to alternative interpretations.

    Reviewed by eLife