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10. Context dependent contributions of the direct and indirect pathways in the associative and sensorimotor striatum

    This article has 6 authors:

    1. Nisa Cuevas
    2. Argelia Llanos-Moreno
    3. Kathia I. Ramírez-Armenta
    4. Hector Alatriste-León
    5. Josué O. Ramírez Jarquin
    6. Fatuel Tecuapetla

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This valuable manuscript shows that the optogenetic stimulation of direct and indirect pathway spiny projection neurons (SPNs) in the dorsomedial versus the dorsolateral striatum has different consequences for locomotor activity, real-time place preference, and action selection, in a contextually mediated manner. The evidence in support of this conclusion is solid but would be further strengthened through deeper analysis of the effect and specificity of optogenetic manipulations on SPN activity. These findings will be of interest to neuroscientists, particularly behavioral neuroscientists.

    Reviewed by eLife