eLife

Latest preprint reviews

1. Exploiting fluctuations in gene expression to detect causal interactions between genes

   This article has 6 authors:

   1. Euan Joly-Smith
   2. Mir Mikdad Talpur
   3. Paige Allard
   4. Fotini Papazotos
   5. Laurent Potvin-Trottier
   6. Andreas Hilfinger

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     By taking advantage of noise in gene expression, this important study introduces a new approach for detecting directed causal interactions between two genes without perturbing either. The main theoretical result is supported by a proof. Preliminary simulations and experiments on small circuits are solid, but further investigations are needed to demonstrate the broad applicability and scalability of the method.

   Reviewed by eLife

2. Exceptional longevity of mammalian ovarian and oocyte macromolecules throughout the reproductive lifespan

   This article has 8 authors:

   1. Ewa K Bomba-Warczak
   2. Karen M Velez
   3. Luhan T Zhou
   4. Christelle Guillermier
   5. Seby Edassery
   6. Matthew L Steinhauser
   7. Jeffrey N Savas
   8. Francesca E Duncan

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study highlights cell types preserving long-lived proteins and lays a foundation for identifying exceptionally long-lived proteins in the ovary. Convincing evidence describes helpful data about protein turnover and identifies long-lived macromolecules in oocytes and somatic cells during mouse ovarian aging. This work will be of interest to researchers working on aging and reproductive health.

   Reviewed by eLife

3. Systematic evaluation of intratumoral and peripheral BCR repertoires in three cancers

   This article has 16 authors:

   1. Sofia V Krasik
   2. Ekaterina A Bryushkova
   3. George V Sharonov
   4. Daria S Myalik
   5. Elizaveta V Shurganova
   6. Dmitry V Komarov
   7. Irina A Shagina
   8. Polina S Shpudeiko
   9. Maria A Turchaninova
   10. Maria T Vakhitova
   11. Igor V Samoylenko
   12. Dimitr T Marinov
   13. Lev V Demidov
   14. Vladimir E Zagaynov
   15. Dmitriy M Chudakov
   16. Ekaterina O Serebrovskaya

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This useful paper systematically evaluates B-cell receptor (BCR) repertoires across tumors, tumor-draining lymph nodes, and peripheral blood in patients with melanoma, lung adenocarcinoma, and colorectal cancer. It investigates the interplay between the tumor microenvironment and immune responses, revealing differences in BCR clonotype maturity, hypermutation, and spatial distribution. The study highlights the heterogeneity in immune responses and provides solid insights into the potential of tumor-infiltrating B cells for therapeutic applications, despite limitations in patient cohort size and sequencing methodology.

   Reviewed by eLife

4. Different coexistence patterns between apex carnivores and mesocarnivores based on temporal, spatial, and dietary niche partitioning analysis in Qilian Mountain National Park, China

   This article has 10 authors:

   1. Wei Cong
   2. Jia Li
   3. Charlotte Hacker
   4. Ye Li
   5. Yu Zhang
   6. Lixiao Jin
   7. Yi Zhang
   8. Diqiang Li
   9. Yadong Xue
   10. Yuguang Zhang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper provides an important assessment of competition dynamics allowing coexistence of the carnivore guild within a large national park in China. Multiple surveying techniques (camera traps and DNA metabarcoding) provide convincing evidence that spatial segregation represents the main strategy of coexistence, while species have a certain degree of temporal and dietary overlap. Altogether, the manuscript provides information critical to the conservation and management agenda of the park.

   Reviewed by eLife

5. Evidence from pupillometry, fMRI, and RNN modelling shows that gain neuromodulation mediates task-relevant perceptual switches

   This article has 10 authors:

   1. Gabriel Wainstein
   2. Christopher J Whyte
   3. Kaylena A Ehgoetz Martens
   4. Eli J Müller
   5. Vicente Medel
   6. Britt Anderson
   7. Elisabeth Stöttinger
   8. James Danckert
   9. Brandon R Munn
   10. James M Shine

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable paper explores the idea that transient modulations of neural gain promote switches between distinct perceptual interpretations of ambiguous stimuli. The authors provide solid evidence for this idea by pupillometry (an indirect proxy of neuromodulatory activity), fMRI, neural network modeling, and dynamical systems analyses. The highly integrative nature of this approach is rare in the field.

   Reviewed by eLife

6. The bile acid receptor TGR5 regulates the hematopoietic support capacity of the bone marrow niche

   This article has 10 authors:

   1. Alejandro Alonso-Calleja
   2. Alessia Perino
   3. Frédérica Schyrr
   4. Silvia Ferreira Lopes
   5. Vasiliki Delitsikou
   6. Antoine Jalil
   7. Ulrike Kettenberger
   8. Dominique P. Pioletti
   9. Kristina Schoonjans
   10. Olaia Naveiras

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study investigates the role of the bile acid receptor TGR5 in adult hematopoiesis of the mouse model. The findings are potentially useful because the loss of TGR5 leads to dysregulation of bone marrow adipose tissue (BMAT) that has emerging regulatory functions. However, the study is still incomplete because the mechanism of TGR5 is not clear, the stromal cells expressing TGR5 have not been well defined, and there is not strong evidence for the role of TGR5 in recovery from transplant stress.

   Reviewed by eLife

7. An arms race between 5’ppp-RNA virus and its alternative recognition receptor MDA5 in RIG-I-lost teleost fish

   This article has 4 authors:

   1. Shang Geng
   2. Xing Lv
   3. Weiwei Zheng
   4. Tianjun Xu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study shows that in teleost fish, the RIG-I-like protein MDA5 can compensate for the absence of RIG-I by detecting 5'-triphosphorylated RNA. A fish virus containing such RNA can nevertheless evade MDA5 detection through a mechanism involving m6A methylation-induced silencing. The conclusions, which are supported by solid data, advance our understanding of antiviral immunity and virus-host conflicts in vertebrates.

   Reviewed by eLife

8. Modulation of biophysical properties of nucleocapsid protein in the mutant spectrum of SARS-CoV-2

   This article has 8 authors:

   1. Ai Nguyen
   2. Huaying Zhao
   3. Dulguun Myagmarsuren
   4. Sanjana Srinivasan
   5. Di Wu
   6. Jiji Chen
   7. Grzegorz Piszczek
   8. Peter Schuck

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important manuscript provides new insights into the biophysics of the SARS-CoV-2 nucleocapsid. The evidence, which relies on a convincing combination of genetic and biophysical data, nicely supports the conclusions.

   Reviewed by eLife

9. Hyperglycemia induced cathepsin L maturation linked to diabetic comorbidities and COVID-19 mortality

   This article has 10 authors:

   1. Qiong He
   2. Miao-Miao Zhao
   3. Ming-Jia Li
   4. Xiao-Ya Li
   5. Jian-Min Jin
   6. Ying-Mei Feng
   7. Li Zhang
   8. Wei Jin Huang
   9. Fangyuan Yang
   10. Jin-Kui Yang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study advances our understanding of why diabetes is a risk factor for more severe Covid-19 disease. The authors offer convincing evidence that cathepsin L is more active in diabetic individuals because of the presence of high glucose, where the main mechanism is increased cathepsin L maturation. This study should be of interest to researchers in diabetes, virology and immunology.

   Reviewed by eLife

10. PURA syndrome-causing mutations impair PUR-domain integrity and affect P-body association

    This article has 17 authors:

    1. Marcel Proske
    2. Robert Janowski
    3. Sabrina Bacher
    4. Hyun-Seo Kang
    5. Thomas Monecke
    6. Tony Koehler
    7. Saskia Hutten
    8. Jana Tretter
    9. Anna Crois
    10. Lena Molitor
    11. Alejandro Varela-Rial
    12. Roberto Fino
    13. Elisa Donati
    14. Gianni De Fabritiis
    15. Dorothee Dormann
    16. Michael Sattler
    17. Dierk Niessing

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This important study addresses the mechanisms by which mutations in the PURA protein, a regulator of gene transcription and mRNA transport and translation, cause the neurodevelopmental PURA syndrome. Based on convincing evidence from structural biology, molecular dynamics simulation, biochemical, and cell biological analyses, the authors show that the PURA structure is very dynamic, rendering it generally sensitive to structure-altering mutations that affect its folding, DNA-unwinding activity, RNA binding, dimerization, and partitioning into processing bodies. These findings are of substantial importance to cell biology, neurogenetics, and neurology alike, because they provide first insights into how very diverse PURA mutations can cause similar and penetrant molecular, cellular, and clinical defects.

    Reviewed by eLife