eLife

Latest preprint reviews

1. We couldn't get details of this article at this time:
   10.1101/2024.03.04.583437

2. We couldn't get details of this article at this time:
   10.1101/2024.02.20.581217

3. De novo-designed minibinders expand the synthetic biology sensing repertoire

   This article has 8 authors:

   1. Zara Y Weinberg
   2. Sarah S Soliman
   3. Matthew S Kim
   4. Devan H Shah
   5. Irene P Chen
   6. Melanie Ott
   7. Wendell A Lim
   8. Hana El-Samad

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents a useful investigation of the use of small, de novo-designed protein binding domains (mini-binders) against the Spike protein of SARS-CoV-2 and EGFR, as ligand binding domains on two classes of synthetic receptors, second-generation synNotch (SNIPR) and CAR. The methods and evidence supporting the focused claims are solid. This work will be of interest to synthetic biologists and cell engineers as a starting point to map out the rules for receptor engineering based on mini-binders and ultimately to advance them in biomedical applications.

   Reviewed by eLife

4. Lack of evidence supporting transgenerational effects of non-transmitted paternal alleles on the murine transcriptome

   This article has 3 authors:

   1. Rodrigo Gularte-Mérida
   2. Carole Charlier
   3. Michel Georges

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important article presents the results of a large screen for non-genetic transgenerational effects that may influence gene expression and other phenotypes in mice. An extraordinary amount of mouse breeding, phenotyping, and RNA sequencing data provide compelling evidence that, for the phenotypes and genomic regions interrogated in these mouse strains, non-genetic transgenerational effects of appreciable magnitude are likely to be extremely rare. This paper will be of broad interest to geneticists and of particular interest to those studying epigenetic inheritance.

   Reviewed by eLife

5. We couldn't get details of this article at this time:
   10.21203/rs.3.rs-3486655/v1

6. FoxO factors are essential for maintaining organ homeostasis by acting as stress sensors in airway epithelial cells

   This article has 19 authors:

   1. Karin Uliczka
   2. Judith Bossen
   3. Ulrich M. Zissler
   4. Christine Fink
   5. Xiao Niu
   6. Mario Pieper
   7. Ruben D. Prange
   8. Christina Vock
   9. Christina Wagner
   10. Mirjam Knop
   11. Ahmed Abdelsadik
   12. Sören Franzenburg
   13. Iris Bruchhaus
   14. Michael Wegmann
   15. Carsten B. Schmidt-Weber
   16. Peter König
   17. Petra Pfefferle
   18. Holger Heine
   19. Thomas Roeder

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study investigates, from Drosophila to mammals, the role of the Forkhead box O (FoxO) transcription factors in airway epithelial cells' response to stressors including hypoxia, temperature variations, and oxidative stress. The findings suggest a conserved role of FoxO in maintaining airway homeostasis across species. However, limitations in the specificity and concerns with the loss-of-function experiments render the evidence presented incomplete. Nonetheless, this study highlights FoxO's potential relevance in respiratory diseases like asthma and offers insights into potential therapeutic targets for conditions affecting airway health.

   Reviewed by eLife

7. We couldn't get details of this article at this time:
   10.1101/2024.01.08.23300523

8. We couldn't get details of this article at this time:
   10.1101/2023.09.07.556692

9. We couldn't get details of this article at this time:
   10.1101/2024.02.07.579273

10. We couldn't get details of this article at this time:
    10.1101/2024.03.06.583718