eLife

Latest preprint reviews

1. Dual-format attentional template during preparation in human visual cortex

   This article has 5 authors:

   1. Yilin Chen
   2. Taosheng Liu
   3. Ke Jia
   4. Jan Theeuwes
   5. Mengyuan Gong

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     By combining the 'pinging' technique with fMRI-based multivariate pattern analysis, this important study provides compelling evidence for a dual-format representation of attention during the preparatory period. The findings help reconcile the debate between sensory-like and non-sensory accounts of attentional templates and shed light on how the brain flexibly deploys different forms of templates to guide attention. This work will be of broad interest to researchers in psychology, vision science, and cognitive neuroscience.

   Reviewed by eLife

2. Rhythmic circuit function is more robust to changes in synaptic than intrinsic conductances

   This article has 3 authors:

   1. Zachary Fournier
   2. Leandro M Alonso
   3. Eve Marder

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study provides compelling insights into the differential impact of intrinsic and synaptic conductances on circuit robustness using computational models of the pyloric network from the crustacean stomatogastric ganglion. The results demonstrate that model networks are more sensitive to perturbations in intrinsic conductances than in synaptic conductances, highlighting the critical role of intrinsic plasticity in stabilizing neuronal networks. These findings underscore the importance of intrinsic plasticity, a crucial yet often overlooked factor in neuronal dynamics. The generality of these conclusions should be tested across diverse networks and functions.

   Reviewed by eLife

3. Dependence of contextual modulation in macaque V1 on interlaminar signal flow

   This article has 5 authors:

   1. Shude Zhu
   2. Yu Jin Oh
   3. Ethan B Trepka
   4. Xiaomo Chen
   5. Tirin Moore

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The results by Zhu et al provide valuable insights into the representation of border ownership in area V1. They used neuropixel recording to demonstrate the clustering of border ownership, and compared cross-correlation functions between neurons in different layers to demonstrate that they depend on the type of stimulus. The strength of the evidence is solid but can be improved by performing additional analyses and addressing some concerns (as raised in the previous and current review), and accounting for the differences in classical and non-classical receptive field stimulation conditions.

   Reviewed by eLife

4. Criterion placement threatens the construct validity of neural measures of consciousness

   This article has 5 authors:

   1. Johannes Jacobus Fahrenfort
   2. Philippa A Johnson
   3. Niels A Kloosterman
   4. Timo Stein
   5. Simon van Gaal

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This fundamental study provides a critical challenge to a great many studies of the neural correlates of consciousness that were based on post hoc sorting of reported awareness experience. The evidence supporting this criticism is compelling, based on simulations and decoding analysis of EEG data. The results will be of interest not only to psychologists and neuroscientists but also to philosophers who work on addressing mind-body relationships.

   Reviewed by eLife

5. Brainstem neurons coordinate the bladder and urethral sphincter for urination

   This article has 14 authors:

   1. Xing Li
   2. Xianping Li
   3. Jun Li
   4. Han Qin
   5. Shanshan Liang
   6. Jun Li
   7. Tingliang Jian
   8. Xia Wang
   9. Lingxuan Yin
   10. Chunhui Yuan
   11. Xiang Liao
   12. Hongbo Jia
   13. Xiaowei Chen
   14. Jiwei Yao

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In this important study, Li et al. identify estrogen receptor 1-expressing neurons (ESR1+) in Barrington's nucleus as key regulators coordinating both bladder contraction and the relaxation of the external urethral sphincter. Using appropriate and validated methodologies aligned with the current state of the art, the data are convincing and of generally high quality.

   Reviewed by eLife

6. Axon-specific microtubule regulation drives asymmetric regeneration of sensory neuron axons

   This article has 12 authors:

   1. Ana Catarina Costa
   2. Blanca R Murillo
   3. Rita Bessa
   4. Ricardo Ribeiro
   5. Tiago Ferreira da Silva
   6. Patrícia Porfírio-Rodrigues
   7. Gabriel G Martins
   8. Pedro Brites
   9. Matthias Kneussel
   10. Thomas Misgeld
   11. Monika S Brill
   12. Monica M Sousa

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In their important manuscript, Costa et al. establish an in vitro model for dorsal root ganglion (DRG) axonal asymmetry, revealing that central and peripheral axon branches have distinct patterns of microtubule populations that are linked to their differential regenerative capacities. The authors employ creative tissue culture methods to demonstrate how these branches develop uniquely in vitro, offering a potential explanation for long-observed regeneration disparities. The convincing evidence provides a contribution to our understanding of the neuronal cytoskeleton and axonal regeneration.

   Reviewed by eLife

7. A Novel Rapid Host Cell Entry Pathway Determines Intracellular Fate of Staphylococcus aureus

   This article has 15 authors:

   1. Marcel Rühling
   2. Fabio Schmelz
   3. Kim Ulbrich
   4. Fabian Schumacher
   5. Julia Wolf
   6. Maximilian Pfefferle
   7. Magdalena Priester
   8. Adriana Moldovan
   9. Nadine Knoch
   10. Andreas Iwanowitsch
   11. Christian Kappe
   12. Kerstin Paprotka
   13. Burkhard Kleuser
   14. Christoph Arenz
   15. Martin J Fraunholz

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study proposes a novel rapid-entry mechanism for Staphylococcus aureus, involving the rapid release of calcium from lysosomes. The paper's strength lies in its very interesting hypothesis. The methods used are solid and adequately support the conclusions.

   Reviewed by eLife

8. Still waters run deep in large-scale genome rearrangements of morphologically conservative Polyplacophora

   This article has 5 authors:

   1. Julia D Sigwart
   2. Yunlong Li
   3. Zeyuan Chen
   4. Katarzyna Vončina
   5. Jin Sun

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study advances our understanding of genome annotations for chiton genomes. It provides a solid estimation of syntentic relationships for the chromosomes of the four new genomes plus an analysis linking these to other available chiton genomes, and an update for how these relate to molluscan genomes.

   Reviewed by eLife

9. The long noncoding RNA lnc-FANCI-2 intrinsically restricts RAS signaling in human papillomavirus type 16-infected cervical cancer cells

   This article has 9 authors:

   1. Haibin Liu
   2. Lulu Yu
   3. Vladimir Majerciak
   4. Thomas J Meyer
   5. Ming Yi
   6. Peter F Johnson
   7. Maggie Cam
   8. Douglas R Lowy
   9. Zhi-Ming Zheng

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study reports important new insights into the roles of a long noncoding RNA, lnc-FANCI-2, in the progression of cervical cancer induced by a type of human papillomavirus. Through a blend of cell biological, biochemical, and genetic analyses of RNA and protein expression, protein-protein interaction, cell signaling, and cell morphology, the authors provide convincing evidence that lnc-FANCI-2 affects cervical cancer outcome by regulating the RAS signaling pathway. These findings will be of interest to scientists in the fields of cervical cancer, long noncoding RNA, and cell signaling.

   Reviewed by eLife

10. Decoding Liver Cancer Prognosis: From Multi-omics Subtypes, Prognostic Models to Single Cell Validation

    This article has 12 authors:

    1. Yanbin Wang
    2. Yuqi Wu
    3. Hong Zhang
    4. Xinyue Liu
    5. Jing Ling
    6. Xiao Zhou
    7. Anping Song
    8. Li Sun
    9. Hong Qiu
    10. Xianglin Yuan
    11. Hua Xiong
    12. Yanmei Zou

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This important revised manuscript presents compelling findings by delineating two molecularly distinct liver cancer subtypes through comprehensive multi-omics integration and constructing a rigorously validated prognostic model. The authors have strengthened the analytical framework and validation across multiple datasets, including single-cell RNA sequencing. The evidence remains robust, with enhanced methodological clarity and expanded validation in both internal and independent cohorts. The revisions have improved the study's rigor and translational relevance.

    Reviewed by eLife