eLife

Latest preprint reviews

1. Photoreceptor loss does not recruit neutrophils despite strong microglial activation

   This article has 3 authors:

   1. Derek Power
   2. Justin Elstrott
   3. Jesse Schallek

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The study by Power and colleagues is important, as elucidating the dynamic immune responses to photoreceptor damage in vivo potentiates future work in the field to better understand the disease process. The evidence supporting the authors' claims is compelling.

   Reviewed by eLife

2. An altered cell-specific subcellular distribution of translesion synthesis DNA polymerase kappa (POLK) in aging neurons

   This article has 6 authors:

   1. Mofida Abdelmageed
   2. Premkumar Palanisamy
   3. Victoria Vernail
   4. Yuval Silberman
   5. Shilpi Paul
   6. Anirban Paul

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript details important findings that DNA polymerase kappa shows age-related changes in subcellular localization within different cell types in the brains of mice, from the nucleus in young cells to the cytoplasm in old cells. The authors' findings suggest that age-related alterations in POLK localization could drive mechanistic and functional changes in the aging brain. The authors provide solid evidence for their study, with data broadly supporting their claims with minor weaknesses.

   Reviewed by eLife

3. Reproducibility of in vivo electrophysiological measurements in mice

   This article has 46 authors:

   1. International Brain Laboratory
   2. Kush Banga
   3. Julius Benson
   4. Jai Bhagat
   5. Dan Biderman
   6. Daniel Birman
   7. Niccolò Bonacchi
   8. Sebastian A Bruijns
   9. Kelly Buchanan
   10. Robert AA Campbell
   11. Matteo Carandini
   12. Gaelle A Chapuis
   13. Anne K Churchland
   14. M Felicia Davatolhagh
   15. Hyun Dong Lee
   16. Mayo Faulkner
   17. Berk Gerçek
   18. Fei Hu
   19. Julia Huntenburg
   20. Cole Lincoln Hurwitz
   21. Anup Khanal
   22. Christopher Krasniak
   23. Petrina Lau
   24. Christopher Langfield
   25. Nancy Mackenzie
   26. Guido T Meijer
   27. Nathaniel J Miska
   28. Zeinab Mohammadi
   29. Jean-Paul Noel
   30. Liam Paninski
   31. Alejandro Pan-Vazquez
   32. Cyrille Rossant
   33. Noam Roth
   34. Michael Schartner
   35. Karolina Z Socha
   36. Nicholas A Steinmetz
   37. Karel Svoboda
   38. Marsa Taheri
   39. Anne E Urai
   40. Shuqi Wang
   41. Miles Wells
   42. Steven J West
   43. Matthew R Whiteway
   44. Olivier Winter
   45. Ilana B Witten
   46. Yizi Zhang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This paper represents an important contribution to the field. Summarizing results from neural recording experiments in mice across ten labs, the work provides compelling evidence that basic electrophysiology features, single-neuron functional properties, and population-level decoding are fairly reproducible across labs with proper preprocessing. The results and suggestions regarding preprocessing and quality metrics may be of significant interest to investigators carrying out such experiments in their own labs.

   Reviewed by eLife

4. Bacteriophage infection drives loss of β-lactam resistance in methicillin-resistant Staphylococcus aureus

   This article has 6 authors:

   1. My Tran
   2. Angel J Hernandez Viera
   3. Patricia Q Tran
   4. Erick D Nilsen
   5. Lily Tran
   6. Charlie Y Mo

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The manuscript explores how bacterial evolution in the presence of lytic phages modulates b-lactams resistance and virulence properties in methicillin-resistant Staphylococcus aureus (MRSA). This important work improves our knowledge of how mutation in genes required for phage infection confers sensitivity to b-lactams and alter virulence properties. Altogether, the findings are convincing.

   Reviewed by eLife

5. Location- and feature-based selection histories make independent, qualitatively distinct contributions to urgent visuomotor performance

   This article has 3 authors:

   1. Emily E Oor
   2. Emilio Salinas
   3. Terrence R Stanford

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Oor and colleagues report the potentially independent effects of the spatial and feature-based selection history on visuomotor choices. They outline compelling evidence, tracking the dynamic history effects based on their extremely clever experimental design (urgent version of the search task). Their finding is of fundamental significance, broadening the framework to identify variables contributing to choice behavior and their neural correlates in future studies.

   Reviewed by eLife

6. Reversion to sensitivity explains limited transmission of resistance in a hospital pathogen

   This article has 7 authors:

   1. Kevin C Tracy
   2. Jordan McKaig
   3. Clare Kinnear
   4. Jess Millar
   5. Aaron A King
   6. Andrew F Read
   7. Robert J Woods

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study, which will be of interest to those studying the evolution and maintenance of antibiotic resistance, addresses the hypothesis that antibiotic resistance arising de novo during treatment will carry a higher fitness cost and will revert to susceptibility more readily than resistance that has been transmitted between hosts. There are, however, concerns that the 'putatively transmitted isolates' in this study do not necessarily represent resistant isolates that have been transmitted between hosts. The support for the central claim of different patterns of reversion between isolates with de novo resistance and putatively transmitted resistant isolates is currently incomplete.

   Reviewed by eLife

7. Valence and salience encoding in the central amygdala

   This article has 4 authors:

   1. Mi-Seon Kong
   2. Ethan Ancell
   3. Daniela M Witten
   4. Larry S Zweifel

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This useful work reveals differential activity to food and shock outcomes in central amygdala GABAergic neurons. Evidence supports claims of unconditioned stimulus activity that changes with learning. Compelling evidence that the circular shift method rigorously identifies functional neuron types is also presented. However, the evidence regarding claims related to valence or salience signaling in these neurons is incomplete. This work will be of interest to neuroscientists studying sensory processing and learning in the amygdala.

   Reviewed by eLife

8. Characterization of postsynaptic glutamate transporter functionality in the zebrafish retinal first synapse across different wavelengths

   This article has 3 authors:

   1. Marco Garbelli
   2. Stephanie Niklaus
   3. Stephan CF Neuhauss

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study reveals that Excitatory Amino Acid Transporters play a role in chromatic information processing in the retina. The combination of (double) mutants, behavioral assays, immunohistochemistry, and electroretinograms provides solid evidence supporting the appropriately conservative conclusions. The work will be of interest to neurobiologists working on color vision or retinal processing.

   Reviewed by eLife

9. Becker muscular dystrophy mice showed site-specific decay of type IIa fibers with capillary change in skeletal muscle

   This article has 5 authors:

   1. Daigo Miyazaki
   2. Mitsuto Sato
   3. Naoko Shiba
   4. Takahiro Yoshizawa
   5. Akinori Nakamura

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The authors present three transgenic models carrying three representative exon deletions of the dystrophin gene. The findings presented are valuable to the field of muscle diseases, particularly muscular dystrophies. The evidence provided in the manuscript is convincing, with rigorous biochemical assays and state-of-the-art microscopy methods.

   Reviewed by eLife

10. Subtypes and proliferation patterns of small intestine neuroendocrine tumors revealed by single-cell RNA sequencing

    This article has 9 authors:

    1. Einav Somech
    2. Debdatta Halder
    3. Avishay Spitzer
    4. Chaya Barbolin
    5. Michael Tyler
    6. Reut Halperin
    7. Moshe Biton
    8. Amit Tirosh
    9. Itay Tirosh

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This is a valuable study that uses single-cell RNA sequencing to define tumor-intrinsic transcriptional programs that characterize distinct types of small intestine neuroendocrine tumors. The evidence supporting the claims of the authors is solid, but would benefit from a larger sample size. The work will be of interest to cancer biologists studying neuroendocrine tumors, as well as those studying tumor heterogeneity more broadly.

    Reviewed by eLife