Latest preprint reviews

  1. R-Spondin Mimetic, SZN-043, Induced Proliferation and Expression of Wnt Target Genes, Two Impaired Features in Human Alcohol-Associated Liver Disease

    This article has 15 authors:
    1. Trevor Fisher
    2. Mehaben Patel
    3. Shalaka Deshmukh
    4. Darshini Shah
    5. Chenggang Lu
    6. Maureen Newman
    7. Jay Ye
    8. Russell Fletcher
    9. Geertrui F Vanhove
    10. Jay Tibbitts
    11. Yang Li
    12. Nicholas J Skill
    13. Zhihong Yang
    14. Suthat Liangpunsakul
    15. Helene Baribault
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study highlights the novel role of RSPO mimetic SZN-043 in the activation of hepatic WNT signaling and promoting hepatocyte regeneration. The authors provide convincing evidence of SZN-043 increasing hepatocytes proliferation in various mouse models, including a humanized mouse liver model, ALD model and CCL4 fibrosis model. This study will be of interest to researchers in liver regeneration and repair mechanisms.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
Newer Page 170 of 867 Older