eLife

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1. We couldn't get details of this article at this time:
   10.64898/2025.12.29.696944

2. We couldn't get details of this article at this time:
   10.64898/2026.06.02.729718

3. Identification of key Y4R residues enables the discovery of selective non-peptide small-molecule agonists

   This article has 12 authors:

   1. Tim Pelczyk
   2. Corinna Schüß
   3. Mateusz Skłodowski
   4. Fabian Liessmann
   5. David Jordan
   6. Vivian Ehrlich
   7. Paul Eisenhuth
   8. Jan Stichel
   9. Albert O Gattor
   10. Max Keller
   11. Jens Meiler
   12. Annette G Beck-Sickinger

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study combines peptide engineering, molecular docking, and functional assays to define the molecular basis of ligand recognition and activation of the human Y4 receptor and to identify three novel small-molecule agonists. The evidence supporting the conclusions is convincing, with complementary experimental and computational approaches providing strong support for the proposed receptor-ligand interactions. While concentration-response analyses of the small-molecule agonists and additional structural or mutagenesis studies would further strengthen the work, these are not essential to support the main conclusions. The work will be of interest to researchers studying GPCR pharmacology, structural biology, and ligand discovery.

   Reviewed by eLife

4. We couldn't get details of this article at this time:
   10.1101/2024.02.12.579892

5. We couldn't get details of this article at this time:
   10.64898/2026.04.13.718288

6. The openretina Project: Collaborative Retina Modelling Across Datasets and Species

   This article has 12 authors:

   1. Federico D’Agostino
   2. Thomas Zenkel
   3. Baptiste Lorenzi
   4. Michaela Vystrčilová
   5. Dominic Gonschorek
   6. Samuel Suhai
   7. Samuele Virgili
   8. Alexander S Ecker
   9. Olivier Marre
   10. Larissa Höfling
   11. Thomas Euler
   12. Matthias Bethge

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript presents openretina, an open-source platform that integrates retinal datasets, model training, benchmarking, and in silico analysis tools within a unified framework. The resource is valuable because it addresses long-standing challenges in reproducibility, accessibility, and cross-study comparison in computational retina research, while providing a foundation for community-driven model development and evaluation. The supporting evidence is solid, with the authors demonstrating a functional and well-documented platform across multiple datasets and species, although a clearer discussion of model interpretability, current performance limitations, and data quality standards would strengthen the resource.

   Reviewed by eLife

7. We couldn't get details of this article at this time:
   10.64898/2026.04.09.717470

8. Comparative single-cell transcriptomic roadmap of mammalian fetal ovarian development

   This article has 9 authors:

   1. Yifei Fang
   2. Shiyao Han
   3. Junmei Zhang
   4. Shengcan Xie
   5. Yue Su
   6. IISAGE Consortium
   7. Yulei Wei
   8. Young Tang
   9. Jingyue Ellie Duan

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study provides a cross-species single-cell transcriptomic resource for early female gonadal development in mammals. The data supporting the main conclusion remain incomplete, and experimental validation is needed to strengthen the conclusions. The work will be of interest to reproductive biologists and developmental biologists.

   Reviewed by eLife

9. Opto-MDMi: a dual-lock optogenetic system for robust activation of endogenous p53

   This article has 5 authors:

   1. Tatsuki Tsuruoka
   2. Takashi Sumikama
   3. Sachiya Nakashima
   4. Yuhei Goto
   5. Kazuhiro Aoki

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript describes an important development of several variants of optogenetic tools to control endogenous p53 activity. They are based on peptides competing with Mdm2/MdmX for binding to p53, thus releasing p53 from its negative regulators and stabilizing its cellular levels. In principle, the data are convincing but should be complemented by investigations of p53 target genes at endogenous levels (instead of only reporter constructs). The study therefore remains incomplete but will be of interest to scientists working on optogenetics as well as the p53 field.

   Reviewed by eLife

10. A mitochondrial quality control mechanism reverses the phagosome maturation arrest caused by Mycobacterium tuberculosis

    This article has 20 authors:

    1. Surbhi Verma
    2. Shweta Thakur
    3. Mrinmoy Das
    4. Raman D Sharma
    5. Vikas Yadav
    6. Priya Sharma
    7. Mardiana Marzuki
    8. Shihui Foo
    9. Giulia M Piperno
    10. Mehak Z Khan
    11. Babu Mathew
    12. Meenu Bajpai
    13. Jaswinder Singh Maras
    14. Shanshan Howland
    15. Sovan Sarkar
    16. Federica Benvenuti
    17. Amit Singh
    18. Vinay Nandicoori
    19. Amit Singhal
    20. Dhiraj Kumar

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      Verma and colleagues interrogate the mechanisms of phagosome maturation arrest during Mycobacterium tuberculosis infection. While cellular events that culminate in this arrest have been largely elucidated, involvement of other organelles, such as mitochondria, has not been highlighted mechanistically. In this valuable study, elements of mitochondrial quality control, such as mitophagy and mitochondrial-derived vesicles involvement, are shown to be paramount in the host-pathogen tussle. The evidence supporting the main conclusions is solid, based on multiple complementary approaches and appropriate controls, although some central mechanistic aspects of the proposed pathway remain only partially resolved.

    Reviewed by eLife