Latest preprint reviews

  1. High-Resolution Genome-Wide Maps Reveal Widespread Presence of Torsional Insulation

    This article has 6 authors:
    1. Porter M Hall
    2. Lauren A Mayse
    3. Lu Bai
    4. Marcus B Smolka
    5. B Franklin Pugh
    6. Michelle D Wang
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The Twin Domain model proposed by Lui and Wang proposing that twin supercoiling domains of DNA emerge during transcription were first described decades ago, but direct experimental evidence has been challenging to obtain. Here, the authors make a fundamental contribution by directly measuring DNA torsion in cells using a photoactivatable intrastrand cross-linker compared to controls. They gather compelling data using this clever method, which provides direct evidence in support of the twin-supercoiled domain model, for torsional effects at transcription start and end sites, and thereby uncover novel features of higher order structure of chromatin in yeast. These data are exciting, and the tools will be of interest to anyone studying chromosome structure and gene regulation.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  2. Oxytocin receptor controls promiscuity and development in prairie voles

    This article has 23 authors:
    1. Ruchira Sharma
    2. Kristen M Berendzen
    3. Amanda Everitt
    4. Belinda Wang
    5. Gina Williams
    6. Shuyu Wang
    7. Kara Quine
    8. Rose D Larios
    9. Kimberly LP Long
    10. Nerissa Hoglen
    11. Bibi Alika Sulaman
    12. Marie C Heath
    13. Michael Sherman
    14. Robert Klinkel
    15. Angela Cai
    16. Denis Galo
    17. Lizandro Chan Caamal
    18. Nastacia L Goodwin
    19. Annaliese Beery
    20. Karen L Bales
    21. Katherine S Pollard
    22. Arthur Jeremy Willsey
    23. Devanand S Manoli
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study presents an important finding regarding how partner preference formation and pair bonding behavior are related to the oxytocin receptor gene expression in the NAc and paraventricular nucleus of the hypothalamus in prairie voles. The evidence supporting this claim is solid but could benefit from increased sample size and more thorough behavioral phenotyping. This study will be of interest to social scientists and neuroscientists who work on pair bonding and oxytocin.

    Reviewed by eLife

    This article has 6 evaluationsAppears in 1 listLatest version Latest activity
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