eLife

Latest preprint reviews

1. Tuberculosis susceptibility in genetically diverse mice reveals functional diversity of neutrophils

   This article has 14 authors:

   1. Marietta M Ravesloot-Chavez
   2. Erik Van Dis
   3. Douglas Fox
   4. Andrea Anaya-Sanchez
   5. Scott Espich
   6. Xammy Huu Nguyenla
   7. Sagar Rawal
   8. Helia Samani
   9. Mallory Ballinger
   10. Henry F Thomas
   11. Dmitri I Kotov
   12. Russell E Vance
   13. Michael W Nachman
   14. Sarah A Stanley

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides valuable insights into the host's variable susceptibility to Mycobacterium tuberculosis, using a novel collection of wild-derived inbred mouse lines from diverse geographic locations, along with immunological and single-cell transcriptomic analyses. While the data are convincing, a deeper mechanistic investigation into neutrophil subset functions would have further enhanced the study. This work will interest microbiologists and immunologists in the tuberculosis field.

   Reviewed by eLife

2. Proactive distractor suppression in early visual cortex

   This article has 3 authors:

   1. David Richter
   2. Dirk van Moorselaar
   3. Jan Theeuwes

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important and well-written study uses functional neuroimaging in human observers to provide compelling evidence that activity in the early visual cortex is suppressed at locations that are frequently occupied by a task-irrelevant but salient item. This suppression appears to be general to any kind of stimulus and also occurs in advance of any item actually appearing. The work will be of great interest to psychologists and neuroscientists examining attention, perception, learning and prediction.

   Reviewed by eLife

3. The ESCRT protein CHMP5 restricts bone formation by controlling endolysosome-mitochondrion-mediated cell senescence

   This article has 10 authors:

   1. Fan Zhang
   2. Yuan Wang
   3. Luyang Zhang
   4. Chunjie Wang
   5. Deping Chen
   6. Haibo Liu
   7. Ren Xu
   8. Cole M Haynes
   9. Jae-Hyuck Shim
   10. Xianpeng Ge

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important work advances our understanding of CHMP5's role in regulating osteogenesis through its impact on cellular senescence. The evidence supporting the conclusion is convincing and the revised manuscript is largely improved. This paper holds potential interest for skeletal biologists who study the pathogenesis of age-associated skeletal disorders.

   Reviewed by eLife

4. MorphoCellSorter is an Andrews plot-based sorting approach to rank microglia according to their morphological features

   This article has 17 authors:

   1. Sarah Benkeder
   2. Son-Michel Dinh
   3. Paul Marchal
   4. Priscille De Gea
   5. Muriel Thoby-Brisson
   6. Violaine Hubert
   7. Ines Hristovska
   8. Gabriel Pitollat
   9. Kassandre Combet
   10. Laura Cardoit
   11. Bruno Pillot
   12. Christelle Leon
   13. Marlene Wiart
   14. Serge Marthy
   15. Jérôme Honnorat
   16. Olivier Pascual
   17. Jean-Christophe Comte

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The study describes a useful tool for assessing microglia morphology in a variety of experimental conditions. The MorphoCellSorter provides a solid platform for ranking microglia to reflect their morphology continuum and may offer new insight into changes in morphology associated with injury or disease. While the study provides an alternative approach to existing methods for measuring microglia morphology, the functional significance of the measured morphological changes were not determined.

   Reviewed by eLife

5. Cellular evolution of the hypothalamic preoptic area of behaviorally divergent deer mice

   This article has 5 authors:

   1. Jenny Chen
   2. Phoebe R Richardson
   3. Christopher Kirby
   4. Sean R Eddy
   5. Hopi E Hoekstra

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study identifies species- and sex-specific neuronal cell types and gene expression in the preoptic area (POA) to help understand the evolutionary divergence of social behaviors. The evidence from single-nucleus RNA sequencing and immunostaining is compelling and suggests that cellular differences in the POA may contribute to behavioral variations such as mating and parental care that are apparent in two closely related deer mouse species. These rich observations provide an entry point for future hypothesis-driven experiments to demonstrate a causal role for these populations in sex- or species-variable behaviors in vertebrates. These data will be a resource that is of value to behavioral neuroscientists.

   Reviewed by eLife

6. Molecular dynamics simulations illuminate the role of sequence context in the ELF3-PrD-based temperature sensing mechanism in plants

   This article has 5 authors:

   1. Richard J Lindsay
   2. Rafael Giordano Viegas
   3. Vitor BP Leite
   4. Philip A Wigge
   5. Sonya M Hanson

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In this potentially valuable computational study, the authors conducted atomistic and coarse-grained simulations to probe the temperature-dependent phase behaviors of ELF3, a disordered component of the evening complex in plant. The results aim to highlight the role of polyQ tracts in modulating the temperature sensitivity. The level of evidence is considered incomplete, due to the lack of systematic calibration of the coarse-grained model and limited statistical uncertainty analysis, especially considering the relatively subtle nature of the differences due to temperature change.

   Reviewed by eLife

7. Ferroptosis-related genes mediate tumor microenvironment and prognosis in triple-negative breast cancer via integrated RNA-seq analysis

   This article has 7 authors:

   1. Xuantong Gong
   2. Lishuang Gu
   3. Di Yang
   4. Yu He
   5. Qian Li
   6. Hao Qin
   7. Yong Wang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents a useful finding for the ferroptosis-mediated tumor microenvironment (TME) in triple-negative breast cancer (TNBC) using public single-cell RNA sequencing (scRNA-seq) and bulk RNA sequencing data. The data were collected and analyzed using solid and validated methodology and can be used as a starting point for functional studies of TME in TNBC. The work will be of interest to medical biologists working in the field of TNBC.

   Reviewed by eLife

8. In silico screening by AlphaFold2 program revealed the potential binding partners of nuage-localizing proteins and piRNA-related proteins

   This article has 8 authors:

   1. Shinichi Kawaguchi
   2. Xin Xu
   3. Takashi Soga
   4. Kenta Yamaguchi
   5. Ryuuya Kawasaki
   6. Ryota Shimouchi
   7. Susumu Date
   8. Toshie Kai

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This useful study employs AlphaFold2 to predict interactions among 20 nuage proteins, identifying five novel interaction candidates, three of which are validated experimentally through co-immunoprecipitation. Expanding the analysis to 430 oogenesis-related proteins and screening ~12,000 Drosophila proteins for interactions with Piwi, the study identifies 164 potential binding partners, demonstrating how computational predictions can streamline experimental validation. This study provides a solid basis for further investigations into eukaryotic protein interaction networks.

   Reviewed by eLife

9. Auditory cortex learns to discriminate audiovisual cues through selective multisensory enhancement

   This article has 5 authors:

   1. Song Chang
   2. Beilin Zheng
   3. Les Keniston
   4. Jinghong Xu
   5. Liping Yu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This is an important study that aims to investigate the behavioral relevance of multisensory responses recorded in the auditory cortex. The experiments are elegant and well-designed and are supported by appropriate analyses of the data. Although solid evidence is presented that is consistent with learning-dependent encoding of visual information in auditory cortex, further work is needed to establish the origin and nature of these non-auditory signals and to definitively rule out any effects of movement-related activity.

   Reviewed by eLife

10. An antisense oligonucleotide-based strategy to ameliorate cognitive dysfunction in the 22q11.2 Deletion Syndrome

    This article has 13 authors:

    1. Pratibha Thakur
    2. Martin Lackinger
    3. Anastasia Diamantopoulou
    4. Sneha Rao
    5. Yijing Chen
    6. Khakima Khalizova
    7. Annie Ferng
    8. Curt Mazur
    9. Holly Kordasiewicz
    10. Robert J Shprintzen
    11. Sander Markx
    12. Bin Xu
    13. Joseph A Gogos

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This is an important study that establishes how anti-sense oligonucleotides degrading a specific target protein called EMC10 can rescue neuronal function in models of chromosome 22.11.2 deletions. The authors use human iPSC-derived neurons and a mouse model to provide compelling data for the rescue of cellular and cognitive features of 22.11.2 phenotypes upon ASO regulation of EMC10. These pre-clinical data are of interest because they support reduction of ECM10 as a promising therapeutic strategy.

    Reviewed by eLife