eLife reviews preprints in the life sciences and medicine.

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  3. Founder effects arising from gathering dynamics systematically bias emerging pathogen surveillance

    1. Bradford P Taylor
    2. William P Hanage

    • Curated by eLife

      eLife Assessment

      This important theoretical study introduces an extension to the commonly used SIR model for infectious disease dynamics, to explicitly consider the role of larger group sizes. Instead of the commonly used individual-based network models, the authors developed a simplified approach based on group sampling, with discrete high- and low-risk groups, which makes the results easier to produce and interpret, at the cost of less detail in the model. The evidence is convincing in terms of the soundness of the theoretical projections and the impact that accounting for group sizes may have on inferences from surveillance data. However, it has not yet been demonstrated that the predictions provide more realistic projections when based on real-world data.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  5. Motor unit mechanisms of speed control in mouse locomotion

    1. Kyle Thomas
    2. Rhuna Gibbs
    3. Hugo Marques
    4. Megan R Carey
    5. Samuel J Sober

    • Curated by eLife

      eLife Assessment

      This valuable study characterises the activity of motor units from two of the three anatomical subdivisions ("heads") of the triceps muscle while mice walked on a treadmill at various speeds. Altogether, this is the most thorough characterisation of motor unit activity in walking mice to date, providing convincing evidence for probabilistic recruitment of motor units that differed between the two heads.

    Reviewed by eLife

    14 evaluationsAppears in 1 listLatest version Latest activity
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