eLife

Latest preprint reviews

1. Pyrotinib after trastuzumab-based adjuvant therapy in patients with HER2-positive breast cancer (PERSIST): A multicenter phase II trial

   This article has 17 authors:

   1. Feilin Cao
   2. Zhaosheng Ma
   3. Zenggui Wu
   4. Weizhu Wu
   5. Ouchen Wang
   6. Binbin Cui
   7. Xiaotao Zhu
   8. Jing Hao
   9. Xiaochun Ji
   10. Zhanwen Li
   11. Deyou Tao
   12. Qingjing Feng
   13. Wei Lin
   14. Dongbo Shi
   15. Jingde Shu
   16. Jichun Zhou
   17. Shifen Huang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The study by Ma et al. provides fundamental findings and compelling evidence that Pyrotinib after trastuzumab-based adjuvant therapy in patients with HER2-positive breast cancer (PERSIST): A multicenter phase II trial. The findings enhance the understanding of HER2-positive breast cancer. The claims are fully supported by the types of experiments that were performed.

   Reviewed by eLife

2. Decapping activators Edc3 and Scd6 act redundantly with Dhh1 in post-transcriptional repression of starvation-induced pathways

   This article has 8 authors:

   1. Rakesh Kumar
   2. Fan Zhang
   3. Shreyas Niphadkar
   4. Chisom Onu
   5. Anil Kumar Vijjamarri
   6. Miriam L Greenberg
   7. Sunil Laxman
   8. Alan G Hinnebusch

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study reports on the redundant roles of the decapping activators Edc3 and Scd6 in orchestrating post-transcriptional programs to modulate metabolic responses to nutrients in yeast. The authors employed mutagenesis studies in conjunction with a battery of transcriptome-wide analyses to provide convincing evidence supporting their conclusions. Considering the broad implications of post-transcriptional regulation of gene expression, this study will be of interest across a variety of biomedical disciplines ranging from biochemistry and molecular and cellular biology to those specializing in studying various pathologies.

   Reviewed by eLife

3. Evolutionary and functional analyses reveal a role for the RHIM in tuning RIPK3 activity across vertebrates

   This article has 5 authors:

   1. Elizabeth J Fay
   2. Kolya Isterabadi
   3. Charles M Rezanka
   4. Jessica Le
   5. Matthew D Daugherty

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study provides compelling evidence for the evolutionary diversification and conserved NFκB-inducing function of RHIM-containing RIP kinase proteins across animal lineages, combining thorough bioinformatic analysis with functional assays in human cells. The findings are of broad interest to immunologists and evolutionary biologists, though some novel observations would benefit from deeper conceptual integration.

   Reviewed by eLife

4. Mid1 deletion leads to cognitive dysfunction in Opitz syndrome by regulates neural rhythms through the inhibition of p-Creb by PP2Ac

   This article has 9 authors:

   1. Ziye Yang
   2. Pengxiang Li
   3. Yue Chen
   4. Xiaoyu Guo
   5. Ping Liu
   6. Guangjian Ni
   7. Shuang Liu
   8. Liqun Chen
   9. Dong Ming

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides important insights into the role of the Mid1 gene in hippocampal development and its implications in Opitz G/BBB syndrome, with much evidence supporting its impact on synaptic plasticity, neural rhythms, and cognitive functions. The methods, data, and analyses are solid, supporting the claims, presenting several minor weaknesses, and establishing Mid1 as a potential therapeutic target for neurological deficits associated with OS. The conclusions are largely supported by the results, but additional data are needed.

   Reviewed by eLife

5. Accept–reject decision-making revealed via a quantitative and ethological study of C. elegans foraging

   This article has 4 authors:

   1. Jessica A Haley
   2. Tianyi Chen
   3. Mikio Aoi
   4. Sreekanth H Chalasani

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Understanding how neural circuits mediate decision-making is a core problem in neuroscience. In this interesting and important work, the authors use detailed behavioral analysis and rigorous quantitative modeling to convincingly support the idea that the nematode C. elegans uses an "accept-reject" behavioral strategy, based on learned features of its environment, to make decisions upon encountering food patches. The work expands our understanding of the behavioral repertoire of this species, providing a foundation for future mechanistic studies in this powerful model system.

   Reviewed by eLife

6. Calcium transfer from the ER to other organelles for optimal signaling in Toxoplasma gondii

   This article has 7 authors:

   1. Zhu-Hong Li
   2. Beejan Asady
   3. Le Chang
   4. Myriam Andrea Hortua Triana
   5. Catherine Li
   6. Isabelle Coppens
   7. Silvia NJ Moreno

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study shows that calcium stores in the endoplasmic reticulum of the parasitic protozoan, Toxoplasma gondii play a major role in buffering calcium levels in the cytosol as well as other organelles such as the mitochondrion. Advanced imaging techniques, including use of genetically encoded calcium indicators provide compelling evidence for the role of the SERCA-Ca2+ ATPase pump in regulating organellar calcium levels. However, it remains unclear whether intra-organellar calcium transport occurs via ER-mitochondria membrane contact sites or other mechanisms. This work will be of interest to cell and molecular biologists interested in calcium signalling in divergent eukaryotes.

   Reviewed by eLife

7. Defensive symbionts provide high protection against natural enemies at low cost to hosts: a meta-analysis

   This article has 3 authors:

   1. Cássia Siqueira Cesar
   2. Eduardo SA Santos
   3. Rodrigo Cogni

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study makes a valuable advance in our understanding of defensive symbionts in insects. It uses a meta-analysis to quantify the magnitude of change in host fitness components when symbionts are present in hosts exposed to natural enemies. The evidence supporting the study conclusions is solid, with analyses confirming common assumptions that symbionts generally provide defence at low cost to hosts.

   Reviewed by eLife

8. The title and authors for this article are not available from our external data provider yet:
   10.48550/arxiv.2404.17495v1

9. Rejuvenating aged osteoprogenitors for bone repair

   This article has 8 authors:

   1. Joshua Reeves
   2. Pierre Tournier
   3. Pierre Becquart
   4. Robert Carton
   5. Yin Tang
   6. Alessandra Vigilante
   7. Dong Fang
   8. Shukry J Habib

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Aging reduces tissue regeneration capacity, posing challenges for an aging population. In this fundamental study, Reeves et al. show that by combining Wnt-mediated osteoprogenitor expansion (using a special bandage) with intermittent fasting, calvarial bone healing can be restored in aged animals. Intermitted fasting improves osteoprogenitor function by rescuing aging-related mitochondrial dysfunction, which can also be achieved by nicotinamide mononucleotide (NMN) supplementation or by modulating the gut microbiome. By employing rigorous histological, transcriptomic, and imaging analyses in a clinically relevant model, the authors provide compelling evidence supporting the conclusions. The therapeutic approach presented in this study shows promise for rejuvenating tissue repair, not only in bones but potentially across other tissues.

   Reviewed by eLife

10. Flower/FLWR-1 regulates neuronal activity via the plasma membrane Ca2+ ATPase to promote recycling of synaptic vesicles

    This article has 9 authors:

    1. Marius Seidenthal
    2. Jasmina Redzovic
    3. Jana F Liewald
    4. Dennis Rentsch
    5. Stepan Shapiguzov
    6. Noah Schuh
    7. Nils Rosenkranz
    8. Stefan Eimer
    9. Alexander Gottschalk

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This important study uses C. elegans to provide new insights into the role of the conserved protein FLWR-1/Flower in synaptic transmission. Employing a variety of techniques, including calcium imaging, ultrastructural analysis, and electrophysiology, the paper provides convincing evidence that challenges some previous thinking about FLWR-1 function. This work will be of particular interest to neuroscientists studying synaptic physiology and plasticity.

    Reviewed by eLife