Latest preprint reviews

  1. β-glucan reprograms macrophages to attenuate efferocytosis of cancer cells

    This article has 5 authors:
    1. Alexandros Chatzis
    2. Jakub Lukaszonek
    3. Dimitris Lagos
    4. Dave Boucher
    5. Ioannis Kourtzelis
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study describes the effect of beta-glucan innate training of macrophages and its effect on uptake of tumour cells and on the production of inflammatory cytokines. The data are convincing and show decreased phagocytic activity of apoptotic tumour cells accompanied by lower levels of secreted IL-1β, and in vivo findings are also provided in the revision. This finding has potential impact on designing potential macrophage-targeted cancer immuno-therapeutic approaches.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  2. Nora virus proliferates in dividing intestinal stem cells and thereby sensitizes Drosophila flies to Pseudomonas aeruginosa intestinal infection and to oxidative stress

    This article has 12 authors:
    1. Adrien Franchet
    2. Samantha Haller
    3. Miriam Yamba
    4. Vincent Barbier
    5. Angelica Thomaz-Vieira
    6. Vincent Leclerc
    7. Stefanie Becker
    8. Kwang-Zin Lee
    9. Igor Orlov
    10. Danièle Spehner
    11. Laurent Daeffler
    12. Dominique Ferrandon
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study shows that the Nora virus, a natural Drosophila pathogen that also persistently infects many laboratory fly stocks, infects intestinal stem cells (ISCs), leading to a shorter life span and increased sensitivity to intestinal infection with the bacterium Pseudomonas. The authors provide convincing data to support their conclusions. The paper provides new insights into virus-host interactions in the Drosophila gut and serves as a warning for scientists who use the fruit fly as a model to study gut physiology.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  3. The mechanism of DRB7.2:DRB4 mediated sequestering of endogenous inverted-repeat dsRNA precursors in plants

    This article has 7 authors:
    1. Sneha Paturi
    2. Debadutta Patra
    3. Priti Chanda Behera
    4. Ramdas Aute
    5. Nilam Waghela
    6. Priyadarshan Kinatukara
    7. Mandar V Deshmukh
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The manuscript provides valuable findings in the field for understanding the RNAi regulation in plants at the molecular level with a model of how DRB7.2 and DRB4 form a heterodimer and protect dsRNA from DICER activity. The presented data provide a solid basis for the model, but certain measurements could benefit from replicates for robust statistics.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
Newer Page 151 of 867 Older