eLife

Latest preprint reviews

1. Old age variably impacts chimpanzee engagement and efficiency in stone tool use

   This article has 7 authors:

   1. Elliot Howard-Spink
   2. Tetsuro Matsuzawa
   3. Susana Carvalho
   4. Catherine Hobaiter
   5. Katarina Almeida-Warren
   6. Thibaud Gruber
   7. Dora Biro

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study provides a novel framework for leveraging longitudinal field observations to examine the effects of aging on stone tool use behaviour in wild chimpanzees. The methods and results are robust providing solid evidence of the effects of old age on nut cracking behaviour at this field site. Despite the low sample size of five individuals, this study is of broad interest to ethologists, primatologists, archaeologists, and psychologists.

   Reviewed by eLife

2. Computational modelling identifies key determinants of subregion-specific dopamine dynamics in the striatum

   This article has 8 authors:

   1. Aske Ejdrup
   2. Jakob Kisbye Dreyer
   3. Matthew D Lycas
   4. Søren H Jørgensen
   5. Trevor W Robbins
   6. Jeffrey Dalley
   7. Freja Herborg
   8. Ulrik Gether

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The conclusions of this work are based on valuable simulations of a detailed model of striatal dopamine dynamics. Establishing that lower dopamine uptake rate can lead to a "tonic" level of dopamine in the ventral but not dorsal striatum, and that dopamine concentration changes at short delays can be tracked by D1 but not D2 receptor activation, is invaluable and will be of interest to the community, particularly those studying dopamine. The model simulations provide convincing evidence for differences between dorsal and ventral striatum dopamine concentrations, while evidence for differential tracking of dopamine changes by D1 vs D2 receptors is solid.

   Reviewed by eLife

3. Human Brain-Wide Activation of Sleep Rhythms

   This article has 5 authors:

   1. Haiteng Wang
   2. Qihong Zou
   3. Jinbo Zhang
   4. Jia-Hong Gao
   5. Yunzhe Liu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The study reports valuable findings from a very rich EEG-fMRI dataset, including 107 participants, which was collected during nocturnal naps. Using overall solid methods, the authors link activity in memory-related brain regions (e.g., hippocampus, thalamus, and medial prefrontal cortex), and their functional connectivity to the occurrence of canonical sleep rhythms (spindles and slow oscillations) in non-rapid eye movement sleep. This work will be of broad interest to sleep and memory researchers and beyond.

   Reviewed by eLife

4. The RAB27A effector SYTL5 regulates mitophagy and mitochondrial metabolism

   This article has 9 authors:

   1. Ana Lapão
   2. Lauren Sophie Johnson
   3. Laura Trachsel-Moncho
   4. Samuel J Rodgers
   5. Sakshi Singh
   6. Matthew YW Ng
   7. Sigve Nakken
   8. Eeva-Liisa Eskelinen
   9. Anne Simonsen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study by Lapao et al. uncovers a novel role for the Rab27A effector SYTL5 in regulating mitochondrial function and mitophagy under hypoxic conditions. Using a range of imaging and functional assays, the authors demonstrate that SYTL5 localizes to mitochondria in a Rab27A-dependent manner and impacts mitochondrial respiration and metabolic reprogramming. While the findings are solid and valuable in the area of cancer biology, further mechanistic clarity and improved imaging would strengthen the conclusions.

   Reviewed by eLife

5. PRMT1-mediated metabolic reprogramming promotes leukemogenesis

   This article has 24 authors:

   1. Hairui Su
   2. Yong Sun
   3. Han Guo
   4. Chiao-Wang Sun
   5. Qiuying Chen
   6. Szumam Liu
   7. Anlun Li
   8. Min Gao
   9. Rui Zhao
   10. Glen Raffel
   11. Jian Jin
   12. Cheng-Kui Qu
   13. Michael Yu
   14. Christopher A Klug
   15. George Y Zheng
   16. Scott Ballinger
   17. Matthew Kutny
   18. Long X Zheng
   19. Zechen Chong
   20. Chamara Senevirathne
   21. Steven Gross
   22. Yabing Chen
   23. Minkui Luo
   24. Xinyang Zhao

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study reveals that PRMT1 overexpression drives tumorigenesis of acute megakaryocytic leukemia (AMKL) and that targeting PRMT1 is a viable approach for treating AMKL. After revision, both reviewers found that these findings are important and that the data supporting these findings are convincing. Furthermore, these findings likely have significant implications for the treatment of AMKL with PRMT1 overexpression in the future.

   Reviewed by eLife

6. A Commander-independent function of COMMD3 in endosomal trafficking

   This article has 5 authors:

   1. Galen T Squiers
   2. Chun Wan
   3. James Gorder
   4. Harrison Puscher
   5. Jingshi Shen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study explores the mechanisms underlying the maintenance of cell surface protein levels. The authors present solid evidence to support their claims, though the addition of certain validation experiments could have further strengthened the conclusions. This work will be of particular interest to cell biologists focused on membrane trafficking.

   Reviewed by eLife

7. Negative regulation of miRNA sorting into EVs is mediated by the capacity of RBP PCBP2 to impair the SYNCRIP-dependent miRNA loading

   This article has 14 authors:

   1. Francesco Marocco
   2. Sabrina Garbo
   3. Claudia Montaldo
   4. Alessio Colantoni
   5. Luca Quattrocchi
   6. Gioele Gaboardi
   7. Giovanna Sabarese
   8. Carla Cicchini
   9. Mario Lecce
   10. Alessia Carnevale
   11. Rossella Paolini
   12. Gian Gaetano Tartaglia
   13. Cecilia Battistelli
   14. Marco Tripodi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript makes a valuable contribution to the field by uncovering a molecular mechanism for miRNA intracellular retention, mediated by the interaction of PCBP2, SYNCRIP, and specific miRNA motifs. The findings are convincing and advance our understanding of RNA-binding protein-mediated miRNA sorting, providing deeper insights into miRNA dynamics.

   Reviewed by eLife

8. Newly discovered and conserved role of IgM against viral infection in an early vertebrate

   This article has 10 authors:

   1. Weiguang Kong
   2. Xinyou Wang
   3. Guangyi Ding
   4. Peng Yang
   5. Yong Shi
   6. Chang Cai
   7. Xinyi Yang
   8. Gaofeng Cheng
   9. Fumio Takizawa
   10. Zhen Xu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The manuscript is an important study which aims to demonstrate the conserved and crucial role of IgM in both systemic and mucosal antiviral immunity in teleost, challenging the established differential roles of IgT and IgM. The strength of the evidence is solid and supported by a combination of in vivo studies, viral infection models, and complementary in vitro assays. In the current version, authors validate the MoAb against IgM

   Reviewed by eLife

9. Clathrin-independent endocytosis and retrograde transport in cancer cells tune immune synapse organization and CD8 T cell response

   This article has 12 authors:

   1. Shiqiang Xu
   2. Alix Buridant
   3. Thibault Hirsch
   4. Céline Duhamel
   5. Benjamin Ledoux
   6. Massiullah Shafaq-Zadah
   7. Estelle Dransart
   8. Louise Thines
   9. Ludger Johannes
   10. Pierre Van der Bruggen
   11. Pierre Morsomme
   12. Henri-François Renard

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study now provides solid evidence for a role of EndoA3-mediated trafficking of ICAM-1 to the immune synapse with T cells. The study will be valuable to those studying cell-cell communication in the immune system, and opens additional questions regarding the mechanisms involved and how other adhesion ligands are regulated.

   Reviewed by eLife

10. Balancing stability and flexibility when reshaping archaeal membranes

    This article has 5 authors:

    1. Miguel Amaral
    2. Felix Frey
    3. Xiuyun Jiang
    4. Buzz Baum
    5. Anđela Šarić

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This fundamental study characterizes the mechanics and stability of bolalipids from archaeal membranes using a minimalist, physics-based computational model. The authors present a robust mesoscale model of bolalipids-containing membranes, systematically evaluating it across diverse membrane configurations. The results are compelling, demonstrating that the incorporation of bolalipids and regular bilayer lipids in archaeal membranes significantly enhances membrane fluidity and structural stability.

    Reviewed by eLife, Arcadia Science