Latest preprint reviews

  1. Specificity Protein 1 is essential for the limb trajectory of ephrin-mediated spinal motor axons

    This article has 11 authors:
    1. Pinwen Liao
    2. Ming-Yuan Chang
    3. Wen-Bin Yang
    4. Keefer Lin
    5. Yi-Chao Li
    6. Jian-Ying Chuang
    7. Yi-Hsin Wu
    8. Artur Kania
    9. Wen-Chang Chang
    10. Tsung-I Hsu
    11. Tzu-Jen Kao
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study makes an important contribution to the molecular mechanisms of neural circuit formation. The data convincingly show that the transcription factor Sp1 regulates ephrin-mediated axon guidance in the spinal cord. Although the authors show that Sp1 and its co-activators p300 and CBP are required to induce ephrin expression, additional discussion and/or experiments are needed to support the claims that Sp1 regulates cis-binding of Epha receptors, or that Sp1 controls ephrin expression in relevant motor neuron populations. The study will be of broad interest to developmental neurobiologists.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  2. Endurance Exercise Ameliorates Aging-Related Bradyarrhythmia in Drosophila Resulting from miR-283 Knockdown in LNvs

    This article has 7 authors:
    1. Qiufang Li
    2. Xu Ping
    3. Zhengwen Yu
    4. Qin Yi
    5. Chao Tang
    6. Xiaoya Wang
    7. Lan Zheng
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study offers valuable insights into the role of miR-283 in ventral-lateral neurons (LNvs) and its impact on senescence, cardiac function, and aging in the Drosophila melanogaster model. However, the evidence supporting some of the conclusions remains incomplete, and further mechanistic studies are needed to clarify how miR-283 affects normal aging and influences exercise adaptations. Nonetheless, the work can be of interest to cell biologists studying miRNA biology, aging, and age-related diseases.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  3. Integrating bulk and single cell RNA-seq refines transcriptomic profiles of individual C. elegans neurons

    This article has 19 authors:
    1. Alec Barrett
    2. Erdem Varol
    3. Alexis Weinreb
    4. Seth R Taylor
    5. Rebecca M McWhirter
    6. Cyril Cros
    7. Berta Vidal
    8. Manasa Basaravaju
    9. Abigail Poff
    10. John A Tipps
    11. Maryam Majeed
    12. Chen Wang
    13. Emily A Bayer
    14. Molly Reilly
    15. Eviatar Yemini
    16. HaoSheng Sun
    17. Oliver Hobert
    18. David M Miller
    19. Marc Hammarlund
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This paper uses a new computational method that integrates bulk sequencing and single-cell sequencing data to provide refined gene expression datasets for 52 neuron classes in C. elegans. The paper's findings are convincing, presenting an approach that alleviates a key shortcoming of single-cell RNA sequencing. While the datasets have some limitations that the authors acknowledge, the new methodology and refined datasets will be important resources for those interested in understanding how gene expression shapes neuronal morphology and physiology.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 3 listsLatest version Latest activity
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