eLife

Latest preprint reviews

1. Screening Envelope Genes Across Primate Genomes Reveals Evolution and Diversity Patterns of Endogenous Retroviruses

   This article has 5 authors:

   1. Saili Chabukswar
   2. Nicole Grandi
   3. Elena Soddu
   4. Liang-Tzung Lin
   5. Enzo Tramontano

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The manuscript provides an important assessment of the number and distribution of different retrovirus env genes present in primate genomes in the form of ancient endogenous retroviruses (ERV loci) and the potential role that viral recombination played in the diversification of retrovirus env genes and their propagation in the primate germline over millions of years. The paper convincingly describes how intermixing/recombination occurs with this viruses, representing a conceptual advance with potentially broad implications.

   Reviewed by eLife

2. An increase in reactive oxygen species underlies neonatal cerebellum repair

   This article has 8 authors:

   1. Anna Pakula
   2. Salsabiel El Nagar
   3. N Sumru Bayin
   4. Jens Bager Christensen
   5. Daniel Stephen
   6. Adam James Reid
   7. Richard P Koche
   8. Alexandra L Joyner

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important work substantially advances our understanding of reactive oxygen species (ROS) as a regenerative signal during postnatal cerebellum repair by activating adaptive progenitor reprogramming. The evidence supporting the conclusions is compelling, with rigorous genomic assays and in vivo analyses. This work will be of broad interest to biologists working on stem cells, neurodevelopment and regenerative medicine.

   Reviewed by eLife

3. Branched actin polymerization drives invasive protrusion formation to promote myoblast fusion during mouse skeletal muscle regeneration

   This article has 8 authors:

   1. Yue Lu
   2. Tezin Walji
   3. Pratima Pandey
   4. Chuanli Zhou
   5. Christa W Habela
   6. Scott B Snapper
   7. Rong Li
   8. Elizabeth H Chen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents a valuable finding regarding the role of Arp2/3 and the actin nucleators N-WASP and WAVE complexes in myoblast fusion. The data presented is convincing, and the work will be of interest to biologists studying skeletal muscle stem cell biology in the context of skeletal muscle regeneration.

   Reviewed by eLife

4. The first complete 3D reconstruction and morphofunctional mapping of an insect eye

   This article has 10 authors:

   1. Anastasia A Makarova
   2. Nicholas J Chua
   3. Anna V Diakova
   4. Inna A Desyatirkina
   5. Pat Gunn
   6. Song Pang
   7. C Shan Xu
   8. Harald F Hess
   9. Dmitri B Chklovskii
   10. Alexey A Polilov

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study sets new standards in analyzing the ultrastructure of insect eyes, which have long served as models for understanding how vision works. The way it describes an entire eye with the resolution of electron microscopy is convincing. On top of this, a miniaturized visual system provides additional, remarkable insights towards understanding optimized solutions.

   Reviewed by eLife

5. Efficacy and safety of neoadjuvant stereotactic body radiation therapy plus dalpiciclib and exemestane for hormone receptor-positive, HER2-negative breast cancer: A prospective pilot study

   This article has 21 authors:

   1. Yu Zhang
   2. Shuo Cao
   3. Nan Niu
   4. Huilian Shan
   5. Jinqi Xue
   6. Guanglei Chen
   7. Yongqing Xu
   8. Jianqiao Yin
   9. Chao Liu
   10. Lisha Sun
   11. Xiaofan Jiang
   12. Meiyue Tang
   13. Qianshi Xu
   14. Mingxuan Jia
   15. Xu Zhang
   16. Zhenyong Zhang
   17. Qingfu Zhang
   18. Jianfei Wang
   19. Ailin Li
   20. Yongliang Yang
   21. Caigang Liu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The study evaluates the feasibility, safety, and tolerability of neoadjuvant radiotherapy followed by a CDK4/6 inhibitor (dalpiciclib) and hormonal therapy in treatment-naive patients with unilateral early-stage HR+/HER2- breast cancer. The findings are convincing, with a strong scientific rationale supported by integrated correlative studies. The trial is considered to be important as the outcomes could inform the design of larger, future studies. The limitations of the study have been acknowledged and outlined in this manuscript, which include only a small cohort of patients (n=12), which was not adequately powered to definitively assess the efficacy or safety of this combinatorial treatment approach.

   Reviewed by eLife

6. Opening and closing of a cryptic pocket in VP35 toggles it between two different RNA-binding modes

   This article has 5 authors:

   1. Upasana L Mallimadugula
   2. Matthew A Cruz
   3. Neha Vithani
   4. Maxwell I Zimmerman
   5. Gregory R Bowman

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides important insights into how cryptic pockets play a role in shaping binding preferences of protein-nucleic acid interactions. By combining biochemical assays and state-of-the-art molecular dynamics simulations, mechanism underlying viral protein 35 (VP35) homologs to bind the backbone of double stranded RNA is presented. The evidence is compelling for molecular determinants that suggest two different dsRNA binding modes for VP35 and also underscores the evolutionary importance of these pockets.

   Reviewed by eLife

7. Identifying genetic variations in emm89 Streptococcus pyogenes associated with severe invasive infections

   This article has 19 authors:

   1. Masayuki Ono
   2. Masaya Yamaguchi
   3. Daisuke Motooka
   4. Yujiro Hirose
   5. Kotaro Higashi
   6. Tomoko Sumitomo
   7. Tohru Miyoshi-Akiyama
   8. Rumi Okuno
   9. Takahiro Yamaguchi
   10. Ryuji Kawahara
   11. Hitoshi Otsuka
   12. Noriko Nakanishi
   13. Yu Kazawa
   14. Chikara Nakagawa
   15. Ryo Yamaguchi
   16. Hiroo Sakai
   17. Yuko Matsumoto
   18. Tadayoshi Ikebe
   19. Shigetada Kawabata

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides an important and timely analysis of invasive and non-invasive Streptococcus pyogenes emm89 isolates, which have become a dominant serotype in the past decade. Using genome sequencing of 311 strains from Japan and comparing them with 666 global strains, the authors present compelling evidence in support of the identification of genetic factors linked to the invasive phenotype of emm89. The findings are both theoretically and practically significant in medical microbiology.

   Reviewed by eLife

8. A whole-organism landscape of X-inactivation in humans

   This article has 3 authors:

   1. Bjorn Gylemo
   2. Maike Bensberg
   3. Colm E Nestor

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The study provides a valuable analysis of escape from X-inactivation based on three rare female GTEX-donors with non-mosaic X-inactivation. The methods and analyses are solid and broadly support the authors' claims. Their data are more comprehensive than those presented previously and add significant weight to evidence for which genes are inactivated or escape from X inactivation in humans.

   Reviewed by eLife

9. NR2F2 is required in the embryonic testis for fetal Leydig cell development

   This article has 6 authors:

   1. Aitana Perea-Gomez
   2. Natividad Bellido Carreras
   3. Magali Dhellemmes
   4. Furong Tang
   5. Coralie Le Gallo
   6. Marie-Christine Chaboissier

   Reviewed by eLife

10. Decoding protein phosphorylation during oocyte meiotic divisions using phosphoproteomics

    This article has 8 authors:

    1. Leonid Peshkin
    2. Enrico maria Daldello
    3. Elizabeth S Van Itallie
    4. Matthew Sonnett
    5. Johannes Kreuzer
    6. Wilhelm Haas
    7. Marc W Kirschner
    8. Catherine Jessus

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This important paper describes a comprehensive quantitative phospho-proteomic analysis of the meiotic progression of Xenopus oocytes. Using time-resolved proteomic analyses, the authors provide insights into changes in protein levels and phosphorylation states to an unprecedented depth, quality, and quantitative detail. The key findings are compelling and offer a helpful resource for the scientific community.

    Reviewed by eLife