eLife

Latest preprint reviews

1. Targeted and random mutagenesis of cassava brown streak disease susceptibility factors reveal molecular determinants of disease severity

   This article has 13 authors:

   1. ZJ Daniel Lin
   2. Myia K Stanton
   3. Gabriela L Hernandez
   4. Elizabeth J De Meyer
   5. Zachary von Behren
   6. Katherine Benza
   7. Helene Tiley
   8. Anna Meirink
   9. Emerald Hood
   10. Greg Jensen
   11. Kerrigan B Gilbert
   12. James C Carrington
   13. Rebecca S Bart

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study shows that targeted mutations in specific cassava eIF4E-family genes can reduce infection and disease symptoms caused by cassava brown streak viruses. Through systematic knockouts across the eIF4E gene family, the authors provide convincing evidence that certain double mutants show resistance-associated outcomes. Overall, the work supports practical routes to engineer cassava with improved resistance and clarifies which host factors are relevant for this disease.

   Reviewed by eLife

2. We couldn't get details of this article at this time:
   10.1101/2025.02.26.640339

3. Defined cellular reprogramming of androgen receptor-active prostate cancer to neuroendocrine prostate cancer

   This article has 14 authors:

   1. Shan Li
   2. Kai Song
   3. Huiyun Sun
   4. Yong Tao
   5. Arthur Huang
   6. Vipul Bhatia
   7. Brian Hanratty
   8. Radhika A Patel
   9. Henry W Long
   10. Colm Morrissey
   11. Michael C Haffner
   12. Peter S Nelson
   13. Thomas G Graeber
   14. John K Lee

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The study by Li et al. provides fundamental findings supported by convincing evidence that they defined cellular reprogramming of androgen receptor in neuroendocrine prostate cancer (NEPC). The findings enhance the understanding of the treatment of androgen receptor functions in NEPC.

   Reviewed by eLife

4. We couldn't get details of this article at this time:
   10.1101/2025.02.07.636951

5. We couldn't get details of this article at this time:
   10.1101/2025.02.14.638343

6. We couldn't get details of this article at this time:
   10.1101/2025.01.24.634652

7. Tumor Cell Spatial Organization Directs EGFR/RAS/RAF Pathway Primary Therapy Resistance through YAP Signaling

   This article has 11 authors:

   1. Rachel Nakagawa
   2. Andrew Beardsley
   3. Sophia Durney
   4. Mary-Kate Hayward
   5. Vishvak Subramanyam
   6. Nathaniel P Meyer
   7. Harrison Wismer
   8. Hani Goodarzi
   9. Valerie M Weaver
   10. Daniel Van de Mark
   11. Andrei Goga

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study identifies a role for YAP in regulating tumor cell growth and drug response with differential effects noted based upon growth conditions in monolayer vs spheroid culture. This work has the potential to define more biologically relevant cell culture model systems for drug resistance and define targetable pathways to overcome drug resistance. The findings described are important to the cancer biology field and the evidence supporting the key findings is convincing.

   Reviewed by eLife

8. We couldn't get details of this article at this time:
   10.21203/rs.3.rs-2432269/v3

9. Unsupervised Representation Learning of C. elegans Poses and Behavior Sequences From Microscope Video Recordings

   This article has 2 authors:

   1. Maurice Deserno
   2. Katarzyna Bozek

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study introduces a self-supervised machine learning method to classify C. elegans postures and behaviors directly from video data, offering an alternative to the skeleton-based approaches that rely on often error-prone tracking. This novel approach holds promise for advancing ethology research. That said, the strength of evidence is currently incomplete, as key aspects - including measuring head-tail orientation, increased behavioral interpretability, and quantitative comparisons to established methods - are underdeveloped and would benefit from further validation.

   Reviewed by Arcadia Science, eLife

10. We couldn't get details of this article at this time:
    10.1101/2024.09.26.615254