eLife

Latest preprint reviews

1. Canonical neurodevelopmental trajectories of structural and functional manifolds

   This article has 6 authors:

   1. Alicja Monaghan
   2. Richard. AI Bethlehem
   3. Danyal Akarca
   4. Daniel Margulies
   5. the CALM Team
   6. Duncan E Astle

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study provides insights into the neurodevelopmental trajectories of structural and functional connectivity gradients in the human brain and their potential associations with behaviour and psychopathology. The evidence supporting the findings is solid. This study will be of interest to neuroscientists interested in understanding functional connectivity across development.

   Reviewed by eLife

2. Sex-specific behavioral and thalamo-accumbal circuit adaptations after oxycodone abstinence

   This article has 8 authors:

   1. Yanaira Alonso-Caraballo
   2. Yan Li
   3. Nicholas J Constantino
   4. Megan A Neal
   5. Gillian S Driscoll
   6. Maria Mavrikaki
   7. Vadim Y Bolshakov
   8. Elena H Chartoff

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents valuable evidence of sex differences in oxycodone relapse-related behavior in rats and provides insight into associated synaptic plasticity in the paraventricular thalamus to the nucleus accumbens shell (PVT-NAcSh) circuit. The report reveals that females show heightened cue-induced oxycodone seeking compared to males after 14 days – but not 1 day – of abstinence; however, an increase in synaptic strength from the PVT inputs to the NAcSh was observed in both males and females at 14 days of abstinence. Therefore, whereas the behavioral data and much of the electrophysiology data are solid, the link between them is incomplete. Further investigation of the functional role of the PVT-NAcSh pathway in the observed sex differences in oxycodone relapse and examination of input and cell-type specificity of synaptic alterations would greatly strengthen this study.

   Reviewed by eLife

3. Emergence of Dip2-mediated specific DAG-based PKC signalling axis in eukaryotes

   This article has 10 authors:

   1. Sakshi Shambhavi
   2. Sudipta Mondal
   3. Arnab Chakraborty
   4. Nikita Shukla
   5. Bapin Kumar Panda
   6. Santhosh Kumar
   7. Priyadarshan Kinatukara
   8. Biswajit Pal
   9. Siddhesh S Kamat
   10. Rajan Sankaranarayanan

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This is an interesting study that adds useful new data addressing how different DAG pools influence cellular signaling. The study dissects how the enzyme Dip2 modulates the minor lipid signaling DAG pool, which is distinct from the lipid metabolism DAG pool utilized in membrane production. Overall the analysis is solid and broadly supports the claims.

   Reviewed by eLife

4. Dilated cardiomyopathy-associated RNA-binding motif protein 20 regulates long pre-mRNAs in neurons

   This article has 6 authors:

   1. Giulia Di Bartolomei
   2. Raúl Ortiz
   3. Dietmar Schreiner
   4. Susanne Falkner
   5. Esther EJM Creemers
   6. Peter Scheiffele

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study reports that the RNA binding and cardiomyopathy-associated protein RBM20 is expressed in specific populations of neurons in the CNS, where it binds to and regulates the expression of synapse-related RNAs. This is an important finding because it reveals a new mechanism for gene regulation in neurons by an RNA binding protein previously studied in the heart; the authors also provide data to suggest that the mechanism by which RBM20 acts in neurons may be distinct from the splicing regulation studied in cardiac tissue. The data in support of the binding and regulation of RNAs by RBM20 is compelling, using leading edge sequencing methods to determine RNA binding profiles, and cell type specific genetics for evaluation of function.

   Reviewed by eLife

5. The geometry and dimensionality of brain-wide activity

   This article has 10 authors:

   1. Zezhen Wang
   2. Weihao Mai
   3. Yuming Chai
   4. Kexin Qi
   5. Hongtai Ren
   6. Chen Shen
   7. Shiwu Zhang
   8. Guodong Tan
   9. Yu Hu
   10. Quan Wen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study shows a surprising scale-invariance of the covariance spectrum of large-scale recordings in the zebrafish brain in vivo. A convincing analysis demonstrates that a Euclidean random matrix model of the covariance matrix recapitulates these properties. The results provide several new and insightful approaches for probing large-scale neural recordings.

   Reviewed by eLife

6. Aurora kinase A promotes trained immunity via regulation of endogenous S-adenosylmethionine metabolism

   This article has 16 authors:

   1. Mengyun Li
   2. Huan Jin
   3. Yongxiang Liu
   4. Zining Wang
   5. Lin Li
   6. Tiantian Wang
   7. Xiaojuan Wang
   8. Hongxia Zhang
   9. Bitao Huo
   10. Tiantian Yu
   11. Shoujie Wang
   12. Wei Zhao
   13. Jinyun Liu
   14. Peng Huang
   15. Jun Cui
   16. Xiaojun Xia

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The authors use a range of techniques to examine the role of Aurora Kinase A (AurA) in trained immunity. The study is hypothesis driven, it uses solid experimental approaches, and the data are presented in a logical manner. The findings are valuable to the trained immunity field because they provide an in-depth look at a common inducer of trained immunity, beta-glucan.

   Reviewed by eLife

7. Dissociation of the nuclear basket triggers chromosome loss in aging yeast

   This article has 7 authors:

   1. Mihailo Mirkovic
   2. Jordan McCarthy
   3. Anne Cornelis Meinema
   4. Julie Parenteau
   5. Sung Sik Lee
   6. Sherif Abou Elela
   7. Yves Barral

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This fundamental study reveals that aging in yeast leads to chromosome mis-segregation due to asymmetric partitioning of chromosomes, driven by disruption of the nuclear pore complex and pre-mRNA leakage. The findings are convincingly supported by carefully-designed experimental data with a combination of genetic, molecular biology and cell biology approaches.

   Reviewed by eLife

8. Elevated ubiquitin phosphorylation by PINK1 contributes to proteasomal impairment and promotes neurodegeneration

   This article has 11 authors:

   1. Cong Chen
   2. Tong-Yao Gao
   3. Hua-Wei Yi
   4. Yi Zhang
   5. Tong Wang
   6. Zhi-Ling Lou
   7. Tao-Feng Wei
   8. Yun-Bi Lu
   9. Tingting Li
   10. Chun Tang
   11. Wei-Ping Zhang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides important insights into the role of polyUbiquitination in neurodegenerative diseases, elucidating how pUb promotes neurodegeneration by affecting proteasomal function. The findings not only offer a new perspective on the pathophysiology of neurodegenerative diseases but also provide potential targets for developing new therapeutic strategies. The results provide solid evidence to support the conclusions.

   Reviewed by eLife

9. Human brain dynamics and spatiotemporal trajectories during threat processing

   This article has 2 authors:

   1. Joyneel Misra
   2. Luiz Pessoa

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Using highly sophisticated switching linear dynamical systems (SLDS) analyses applied to functional MRI data, this study provides important insights into network dynamics underlying threat processing. After identifying distinct neural network states associated with varying levels of threat proximity, the paper provides compelling evidence of intrinsically and extrinsically driven contributions to these within-state dynamics and between-state transitions. Although the findings could be made more biologically meaningful, this work will be of interest to a wider functional neuroimaging and systems neuroscience community.

   Reviewed by eLife

10. Gene regulatory dynamics during craniofacial development in a carnivorous marsupial

    This article has 6 authors:

    1. Laura E Cook
    2. Charles Y Feigin
    3. John D Hills
    4. Davide M Vespasiani
    5. Andrew J Pask
    6. Irene Gallego Romero

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This important study of regulatory elements and gene expression in the craniofacial region of the fat-tailed dunnart shows that, compared to placental mammals, marsupial craniofacial tissue develops in a precocious manner, with enhancer regulatory elements as primary driver of this difference. The compelling data, including a new dunnart genome assembly, provide an invaluable reference for future mammalian evolution studies, especially once additional developmental time point for the fat-tailed dunnart become available.

    Reviewed by eLife