eLife

Latest preprint reviews

1. Loss of the s2U tRNA modification induces antibiotic tolerance and is linked to changes in ribosomal protein expression

   This article has 5 authors:

   1. Katherine L Cotten
   2. Abigail McShane
   3. Peter C Dedon
   4. Thomas J Begley
   5. Kimberly M Davis

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This fundamental work examines how tRNA modifications influence antibiotic tolerance, providing novel insights that may have therapeutic uses. The evidence supporting the conclusions is convincing. Strengths of the manuscript include the mechanism of tRNA modification influencing antibiotic tolerance and the precise measurement techniques used throughout. Further analysis of growth rate impacts and specific identification of the proteins responsible for the effect would further strengthen the manuscript.

   Reviewed by eLife

2. The Fd4 transcription factor translates transient spatial cues in progenitors into long-term lineage identity

   This article has 2 authors:

   1. Sen-Lin Lai
   2. Chris Q Doe

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study focuses on the molecular mechanisms underlying the generation of neuronal diversity. Taking advantage of a well-defined neuroblast lineage in Drosophila, the authors provide convincing evidence that two transcription factors of the conserved forkhead box (FOX) family offer a mechanistic link between transient spatial cues that specify neuroblast identity and terminal selector genes that define post-mitotic neuron identity. The findings will be of interest to developmental neurobiologists.

   Reviewed by eLife

3. Continuous flashing suppression of V1 responses and the perceptual consequences revealed via two-photon calcium imaging and transformer modeling

   This article has 5 authors:

   1. Cai-Xia Chen
   2. Xin Wang
   3. Dan-Qing Jiang
   4. Shi-Ming Tang
   5. Cong Yu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study shows that orientation tuning of V1 neurons is suppressed during a continuous flash suppression paradigm, especially when the neurons have a binocular receptive field. However, the evidence presented is incomplete and, in particular, does not distinguish whether this suppression is due to reduced contrast or due to masking.

   Reviewed by eLife

4. In-situ glial cell-surface proteomics identifies pro-longevity factors in Drosophila

   This article has 22 authors:

   1. Madeline P Marques
   2. Bo Sun
   3. Ye-Jin Park
   4. Tyler Jackson
   5. Tzu-Chiao Lu
   6. Yanyan Qi
   7. Erin Harrison
   8. Miranda C Wang
   9. Kartik Venkatachalam
   10. Omar Moussa Pasha
   11. Amogh Varanasi
   12. Dominique Kiki Carey
   13. DR Mani
   14. Jonathan Zirin
   15. Mujeeb Qadiri
   16. Yanhui Hu
   17. Norbert Perrimon
   18. Steven A Carr
   19. Namrata D Udeshi
   20. Liqun Luo
   21. Jiefu Li
   22. Hongjie Li

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Combining state-of-the-art in-situ cell-surface proteomics, functional genetic screening, and single-nucleus RNA sequencing, this fundamental work substantially advances our understanding of glial contributions to organismal lifespan. The evidence supporting the conclusions is compelling, although additional clarification, control experiments, and analysis would further strengthen the study. The work will be of broad interest to researchers studying aging biology, glia-neuron communication, and in vivo proteomic profiling.

   Reviewed by eLife

5. Characterisation of cold-selective lamina I spinal projection neurons

   This article has 12 authors:

   1. Aimi N Razlan
   2. Wenhui Ma
   3. Allen C Dickie
   4. Erika Polgár
   5. Anna McFarlane
   6. Mansi Yadav
   7. Andrew H Cooper
   8. Douglas Strathdee
   9. Masahiko Watanabe
   10. Andrew M Bell
   11. Andrew J Todd
   12. Junichi Hachisuka

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study offers valuable insights into the anatomical and physiological features of cold-selective lamina I spinal projection neurons. The evidence supporting the authors' claims is compelling, although including a larger sample size and more quantification would have strengthened the study further, and the claims of monosynaptic connectivity would benefit from being stated more cautiously. The work will interest those in the field of somatosensory biology, especially researchers studying spinal cord dorsal horn circuits and projection neuron cell types.

   Reviewed by eLife

6. How Occam’s razor guides human decision-making

   This article has 5 authors:

   1. Eugenio Piasini
   2. Shuze Liu
   3. Pratik Chaudhari
   4. Vijay Balasubramanian
   5. Joshua I Gold

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents an important new approach to quantifying parsimony preferences in human inference. The work provides convincing evidence that humans are sensitive to specific formalizations of parsimony, such as the dimensionality of perceptual shapes. The work is considered timely, well-written, and technically sophisticated, effectively bridging concepts from statistical inference and human decision-making.

   Reviewed by eLife

7. EEG decodability of facial expressions and their stereoscopic depth cues in immersive virtual reality

   This article has 7 authors:

   1. Felix Klotzsche
   2. Ammara Nasim
   3. Simon M Hofmann
   4. Arno Villringer
   5. Vadim Nikulin
   6. Werner Sommer
   7. Michael Gaebler

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study successfully decoded visual representations of facial expressions and stereoscopic depth information from electroencephalogram (EEG) signals recorded in an immersive virtual reality (VR) environment. The evidence is solid in demonstrating the technical feasibility of integrating state-of-the-art EEG decoding and VR with eye tracking. This work will interest neuroscience researchers, as well as engineers developing brain-machine interfaces and/or virtual reality displays.

   Reviewed by eLife

8. Persistent contacts between Climp63 and microtubules cause mitotic defects and nuclear fragmentation

   This article has 2 authors:

   1. Jelmi uit de Bos
   2. Ulrike Kutay

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study reveals that mitotic release of an ER-microtubule tether is critical for normal mitotic progression. Manipulating CLIMP63 phosphorylation, the authors provide convincing evidence that persistent microtubule-ER contacts activate the spindle assembly checkpoint and, if mitosis is forced to proceed, drive severe micronucleation. While the study provides new mechanistic insights, some evidence is indirect, and additional experiments would further refine the model.

   Reviewed by eLife

9. Frequency-selective contrast sensitivity modulation driven by fine-tuned exogenous attention at the foveal scale

   This article has 3 authors:

   1. Yue Guzhang
   2. T Florian Jaeger
   3. Martina Poletti

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study explores how exogenous attention operates at the finest spatial scale of vision, within the foveola - a topic that has not been previously explored. The question is important for understanding how attention shapes perception, and how it differs between the periphery and the central regions of highest visual acuity. The evidence is compelling, as shown by carefully designed experiments with state-of-the-art eye tracking to monitor attended locations just a few tens of minutes of arc away from the fixation target, but additional clarification regarding analyses and implications for vision and oculomotor control would broaden the impact of the study.

   Reviewed by eLife

10. Learning-Associated Flexibility of Cortical Taste Coding Is Impaired in Shank3 Knockout Mice

    This article has 2 authors:

    1. Chi-Hong Wu
    2. Gina G Turrigiano

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This valuable study provides solid evidence for deficits in aversive taste learning and taste coding in a mouse model of autism spectrum disorders. Specifically, the authors found that Shank3 knockout mice exhibit behavioral deficits in learning and extinction of conditioned taste aversion, and calcium imaging of the gustatory cortex identified impaired neuronal responses to taste stimuli. This paper will likely be of interest to researchers studying how learning and sensory processes are affected by genetic causes of autism spectrum disorders.

    Reviewed by eLife