eLife

Latest preprint reviews

1. An evolutionarily conserved scheme for reformatting odor concentration in early olfactory circuits

   This article has 4 authors:

   1. Yang Shen
   2. Arkarup Banerjee
   3. Dinu F Albeanu
   4. Saket Navlakha

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This is a valuable computational study of odor responses in the early olfactory system of insects and vertebrates. The study addresses the question of how information about odor concentration is encoded by second-order neurons in the invertebrate and vertebrate olfactory system; it offers insights into the transformation of neural signals from receptors to second-order neurons. While reanalysis of published data presents solid evidence supporting compression of concentration information, incomplete analysis is provided to resolve how this observation could be reconciled with the need to preserve information about changes in stimulus intensity. This work will be of interest to neuroscientists studying sensory processing broadly and olfaction specifically.

   Reviewed by eLife

2. We couldn't get details of this article at this time:
   10.1101/2024.10.14.618159

3. We couldn't get details of this article at this time:
   10.1101/2025.05.18.654693

4. We couldn't get details of this article at this time:
   10.1101/2025.04.25.649966

5. We couldn't get details of this article at this time:
   10.1101/2024.09.05.611298

6. We couldn't get details of this article at this time:
   10.1101/2025.04.11.648316

7. We couldn't get details of this article at this time:
   10.1101/2025.04.30.651446

8. We couldn't get details of this article at this time:
   10.1101/2025.05.21.655295

9. Efficiency and localisation of AURKA degradation by PROTACs is modulated by deubiquitinases UCHL5 and target-selective OTUD6A

   This article has 3 authors:

   1. Annabel Cardno
   2. Karen Roberts
   3. Catherine Lindon

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study describes a genetic screen to identify deubiquitinases (DUBs) that counteract the activity of small molecule degraders (PROTACs). The presented data is valuable, identifying OTUD6A and UCHL5 as DUBs that impact the efficacy and potency of PROTAC-mediated degradation in distinct subcellular compartments. While the conclusions are broadly supported and the methods employed are solid, the validation of OTUD6A and UCHL5 mechanisms requires additional study. Overall, these findings merit further evaluation by the targeted protein degradation community when developing and optimizing PROTACs and efforts to achieve compartment-specific degradation.

   Reviewed by eLife

10. We couldn't get details of this article at this time:
    10.1101/2025.05.18.654759