eLife

Latest preprint reviews

1. Comprehensive Neural Representations of Naturalistic Stimuli through Multimodal Deep Learning

   This article has 5 authors:

   1. Mingxue Fu
   2. Guoqiu Chen
   3. Yijie Zhang
   4. Mingzhe Zhang
   5. Yin Wang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents a valuable application of a video-text alignment deep neural network model to improve neural encoding of naturalistic stimuli in fMRI. The authors provide convincing evidence that models based on multimodal and dynamic embedding features of audiovisual movies predicted brain responses better than models based on unimodal or static features. The work will be of interest to researchers in cognitive neuroscience and AI-based brain modeling.

   Reviewed by eLife

2. We couldn't get details of this article at this time:
   10.1101/2025.01.06.628021

3. We couldn't get details of this article at this time:
   10.1101/2025.06.09.658756

4. An expanded palette of bright and photostable organellar Ca2+ sensors

   This article has 12 authors:

   1. Agathe Moret
   2. Helen Farrants
   3. Ruolin Fan
   4. Kelsey G Zingg
   5. Bryon Silva
   6. Camilla Roselli
   7. Thomas G Oertner
   8. Christine E Gee
   9. Dafni Hadjieconomou
   10. Vidhya Rangaraju
   11. Eric R Schreiter
   12. Jaime de Juan-Sanz

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study introduces a new class of spectrally tunable, dye-based calcium sensors optimized for imaging in organelles with high calcium concentrations, such as the endoplasmic reticulum and mitochondria. The experimental evidence supporting the applicability of these sensors is convincing, with thorough validation in cultured cells and neurons. The work will be of high interest to researchers studying calcium signaling dynamics in subcellular compartments.

   Reviewed by eLife

5. We couldn't get details of this article at this time:
   10.1101/2025.06.27.661943

6. We couldn't get details of this article at this time:
   10.1101/2024.11.25.625241

7. MIRO1 controls energy production and proliferation of vascular smooth muscle cells

   This article has 15 authors:

   1. Lan Qian
   2. Olha M Koval
   3. Benney T Endoni
   4. Denise Juhr
   5. Colleen S Stein
   6. Chantal Allamargot
   7. Li-Hsien Lin
   8. Deng-Fu Guo
   9. Kamal Rahmouni
   10. Antentor O Hinton
   11. E Dale Abel
   12. Ryan L Boudreau
   13. Jennifer Streeter
   14. William H Thiel
   15. Isabella M Grumbach

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study highlights the role of MIRO1 in regulating mitochondrial oxidative phosphorylation in smooth muscle cells, a process that appears necessary to sustain their proliferation. Overall, the work provides convincing evidence that mitochondrial positioning and function influence vascular disease, although several bioenergetic and mechanistic aspects would benefit from deeper investigation.

   Reviewed by eLife

8. We couldn't get details of this article at this time:
   10.1101/2025.06.16.659985

9. We couldn't get details of this article at this time:
   10.1101/2025.05.20.655212

10. Acquired resistance to sotorasib in KRASG12C mutant NSCLC is vulnerable to PI3K-mTOR pathway inhibition mediated by 4E-BP1, a regulator of cap-dependent translation

    This article has 15 authors:

    1. Ismail M Meraz
    2. Shuhong Wu
    3. Yi Xu
    4. Lihui Gao
    5. Meng Feng
    6. Chenghui Ren
    7. Renduo Song
    8. Ran Zhang
    9. Qi Wang
    10. Yuanxin Xi
    11. Sung Yun Jung
    12. Jing Wang
    13. Bingliang Fang
    14. Mourad Majidi
    15. Jack A Roth

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      The authors investigate mechanisms of acquired resistance (AR) to KRAS-G12C inhibitors (sotorasib) in non-small cell lung cancer, proposing that resistance arises from signaling rewiring rather than additional mutations. While the study addresses a valuable clinical question, it is limited by several weaknesses in experimental rigor, data interpretation, and presentation, meaning the strength of evidence is incomplete.

    Reviewed by eLife