Latest preprint reviews

1. Systematic creation and phenotyping of Mendelian disease models in C. elegans : towards large-scale drug repurposing

   This article has 4 authors:

   1. Thomas J. O’Brien
   2. Ida L. Barlow
   3. Luigi Feriani
   4. André E.X. Brown

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study provides proof of principle that C. elegans models can be used to accelerate the discovery of candidate treatments for human Mendelian diseases by detailed high-throughput phenotyping of strains harboring mutations in orthologs of human disease genes. The data are compelling and support an approach that enables the potential rapid repurposing of FDA-approved drugs to treat rare diseases for which there are currently no effective treatments. The authors should provide a clearer explanation of how the statistical analyses were performed, as well as a link to a GitHub repository to clarify how figures and tables in the manuscript were generated from the phenotypic data.

   Reviewed by eLife, Arcadia Science

2. Improved green and red GRAB sensors for monitoring dopaminergic activity in vivo

   This article has 23 authors:

   1. Yizhou Zhuo
   2. Bin Luo
   3. Xinyang Yi
   4. Hui Dong
   5. Xiaolei Miao
   6. Jinxia Wan
   7. John T. Williams
   8. Malcolm G. Campbell
   9. Ruyi Cai
   10. Tongrui Qian
   11. Fengling Li
   12. Sophia J. Weber
   13. Lei Wang
   14. Bozhi Li
   15. Yu Wei
   16. Guochuan Li
   17. Huan Wang
   18. Yu Zheng
   19. Yulin Zhao
   20. Marina E. Wolf
   21. Yingjie Zhu
   22. Mitsuko Watabe-Uchida
   23. Yulong Li

   Reviewed by Arcadia Science

3. Comparison of de novo and reference genome-based transcriptome assembly pipelines for differential expression analysis of RNA sequencing data

   This article has 6 authors:

   1. Rebekah A. Oomen
   2. Halvor Knutsen
   3. Esben M. Olsen
   4. Sissel Jentoft
   5. Nils Chr. Stenseth
   6. Jeffrey A. Hutchings

   Reviewed by Arcadia Science

4. Targeted decontamination of sequencing data with CLEAN

   This article has 5 authors:

   1. Marie Lataretu
   2. Sebastian Krautwurst
   3. Adrian Viehweger
   4. Christian Brandt
   5. Martin Hölzer

   Reviewed by Arcadia Science

5. Epithelial Ca ²⁺ waves triggered by enteric neurons heal the gut

   This article has 6 authors:

   1. Afroditi Petsakou
   2. Yifang Liu
   3. Ying Liu
   4. Aram Comjean
   5. Yanhui Hu
   6. Norbert Perrimon

   Reviewed by Arcadia Science

6. Centripetal integration of past events in hippocampal astrocytes regulated by locus coeruleus

   This article has 6 authors:

   1. Peter Rupprecht
   2. Sian N. Duss
   3. Denise Becker
   4. Christopher M. Lewis
   5. Johannes Bohacek
   6. Fritjof Helmchen

   Reviewed by Arcadia Science

7. Binding and sequestration of poison frog alkaloids by a plasma globulin

   This article has 10 authors:

   1. Aurora Alvarez-Buylla
   2. Marie-Therese Fischer
   3. Maria Dolores Moya Garzon
   4. Alexandra E Rangel
   5. Elicio E Tapia
   6. Julia T Tanzo
   7. H Tom Soh
   8. Luis A Coloma
   9. Jonathan Z Long
   10. Lauren A O'Connell

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Poison frogs sequester alkaloids to make themselves toxic or unpalatable to predators, but how this sequestration occurs is not well understood. This valuable study identifies an alkaloid-binding protein in the plasma of poison frogs, which may help explain how these animals are able to sequester a diversity of alkaloids with different target sites. The supporting evidence is solid and the study adds to our understanding of how toxic animals resist the effects of their own defenses.

   Reviewed by eLife, Arcadia Science

8. Non-invasive Analysis of Peptidoglycan from Living Animals

   This article has 8 authors:

   1. Karl L. Ocius
   2. Sree H. Kolli
   3. Saadman S. Ahmad
   4. Jules M. Dressler
   5. Mahendra D. Chordia
   6. Brandon L. Jutras
   7. Melanie R. Rutkowski
   8. Marcos M. Pires

   Reviewed by Arcadia Science

9. Characterization of a selective, iron-chelating antifungal compound that disrupts fungal metabolism and synergizes with fluconazole

   This article has 12 authors:

   1. Jeanne Corrales
   2. Lucia Ramos-Alonso
   3. Javier González-Sabín
   4. Nicolás Ríos-Lombardía
   5. Nuria Trevijano-Contador
   6. Henriette Engen Berg
   7. Frøydis Sved Skottvoll
   8. Francisco Moris
   9. Oscar Zaragoza
   10. Pierre Chymkowitch
   11. Ignacio Garcia
   12. Jorrit M. Enserink

   Reviewed by Arcadia Science

10. MetaCerberus: distributed highly parallelized scalable HMM-based implementation for robust functional annotation across the tree of life

    This article has 4 authors:

    1. Jose L. Figueroa
    2. Eliza Dhungel
    3. Cory R. Brouwer
    4. Richard Allen White

    Reviewed by Arcadia Science